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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12008

FusionGeneSummary for ERG_CDHR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_CDHR2
Fusion gene ID: 12008
HgeneTgene
Gene symbol

ERG

CDHR2

Gene ID

2078

54825

Gene nameERG, ETS transcription factorcadherin related family member 2
Synonymserg-3|p55PCDH24|PCLKC
Cytomap

21q22.2

5q35.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 oncadherin-related family member 2protocadherin-24
Modification date2018052320180519
UniProtAcc

P11308

Q9BYE9

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000510636, ENST00000261944, 
ENST00000506348, 
Fusion gene scores* DoF score15 X 4 X 3=1803 X 2 X 3=18
# samples 193
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERG [Title/Abstract] AND CDHR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneCDHR2

GO:0030855

epithelial cell differentiation

12117771

TgeneCDHR2

GO:0044331

cell-cell adhesion mediated by cadherin

12117771

TgeneCDHR2

GO:0060243

negative regulation of cell growth involved in contact inhibition

12117771


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5744-01AERGchr21

39947586

-CDHR2chr5

175992339

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000398907ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000398907ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000398907ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000398905ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000398905ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000398905ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000288319ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000288319ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000288319ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000398897ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000398897ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000398897ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398911ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398911ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398911ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398910ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398910ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398910ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000417133ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000417133ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000417133ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000442448ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000442448ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000442448ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000453032ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000453032ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000453032ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398919ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398919ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5CDS-5UTRENST00000398919ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000429727ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000429727ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
intron-5UTRENST00000429727ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000485493ENST00000510636ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000485493ENST00000261944ERGchr21

39947586

-CDHR2chr5

175992339

+
5UTR-5UTRENST00000485493ENST00000506348ERGchr21

39947586

-CDHR2chr5

175992339

+

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FusionProtFeatures for ERG_CDHR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

CDHR2

Q9BYE9

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. Intermicrovillar adhesion molecule that forms, via itsextracellular domain, calcium-dependent heterophilic complexeswith CDHR5 on adjacent microvilli. Thereby, controls the packingof microvilli at the apical membrane of epithelial cells. Throughits cytoplasmic domain, interacts with microvillus cytoplasmicproteins to form the intermicrovillar adhesion complex/IMAC. Thiscomplex plays a central role in microvilli and epithelial brushborder differentiation (PubMed:24725409). May also play a role incell-cell adhesion and contact inhibition in epithelial cells(PubMed:12117771). {ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:24725409}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_CDHR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_CDHR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3CDHR2MAST2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_CDHR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_CDHR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human