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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12006

FusionGeneSummary for ERG_ABCC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG_ABCC4
Fusion gene ID: 12006
HgeneTgene
Gene symbol

ERG

ABCC4

Gene ID

2078

10257

Gene nameERG, ETS transcription factorATP binding cassette subfamily C member 4
Synonymserg-3|p55MOAT-B|MOATB|MRP4
Cytomap

21q22.2

13q32.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 onmultidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter
Modification date2018052320180523
UniProtAcc

P11308

O15439

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000412704, ENST00000376887, 
ENST00000536256, ENST00000431522, 
ENST00000538287, ENST00000474158, 
Fusion gene scores* DoF score15 X 4 X 3=1804 X 4 X 3=48
# samples 194
** MAII scorelog2(19/180*10)=0.0780025120012732
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND ABCC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneABCC4

GO:0032310

prostaglandin secretion

25173977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XQ-A8TB-01AERGchr21

39947586

-ABCC4chr13

95900007

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398907ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398907ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398907ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3UTRENST00000398907ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-intronENST00000398907ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398905ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398905ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398905ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000398905ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3UTRENST00000398905ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-intronENST00000398905ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000288319ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000288319ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000288319ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000288319ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3UTRENST00000288319ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-intronENST00000288319ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000398897ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000398897ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000398897ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000398897ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3UTRENST00000398897ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-intronENST00000398897ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398911ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398911ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398911ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398911ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-3UTRENST00000398911ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-intronENST00000398911ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398910ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398910ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398910ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398910ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-3UTRENST00000398910ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-intronENST00000398910ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000417133ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000417133ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000417133ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000417133ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-3UTRENST00000417133ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-intronENST00000417133ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000442448ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000442448ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000442448ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000442448ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-3UTRENST00000442448ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-intronENST00000442448ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000453032ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000453032ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000453032ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000453032ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3UTRENST00000453032ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-intronENST00000453032ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398919ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398919ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398919ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
Frame-shitENST00000398919ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-3UTRENST00000398919ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5CDS-intronENST00000398919ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000429727ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000429727ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000429727ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3CDSENST00000429727ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-3UTRENST00000429727ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
intron-intronENST00000429727ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000485493ENST00000412704ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000485493ENST00000376887ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000485493ENST00000536256ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3CDSENST00000485493ENST00000431522ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-3UTRENST00000485493ENST00000538287ERGchr21

39947586

-ABCC4chr13

95900007

-
5UTR-intronENST00000485493ENST00000474158ERGchr21

39947586

-ABCC4chr13

95900007

-

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FusionProtFeatures for ERG_ABCC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

P11308

ABCC4

O15439

Transcriptional regulator. May participate intranscriptional regulation through the recruitment of SETDB1histone methyltransferase and subsequent modification of localchromatin structure. May be an organic anion pump relevant to cellulardetoxification.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERG_ABCC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERG_ABCC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3ABCC4HAX1, ERBB2IP, SLC9A3R1, SLC9A3R2, PDZK1, SNTA1, CFTR, SNX27, LGALS3, LGALS8, LGALS9C, LPAR1, ATP2B2, SLC4A8, REEP5, TMEM128, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERG_ABCC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERG_ABCC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms5CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneABCC4C0003873Rheumatoid Arthritis1CTD_human
TgeneABCC4C0009404Colorectal Neoplasms1CTD_human
TgeneABCC4C0014175Endometriosis1CTD_human
TgeneABCC4C0027627Neoplasm Metastasis1CTD_human
TgeneABCC4C0033578Prostatic Neoplasms1CTD_human
TgeneABCC4C0041755Adverse reaction to drug1CTD_human
TgeneABCC4C0236969Substance-Related Disorders1CTD_human