FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12000

FusionGeneSummary for ERGIC1_RANBP17

check button Fusion gene summary
Fusion gene informationFusion gene name: ERGIC1_RANBP17
Fusion gene ID: 12000
HgeneTgene
Gene symbol

ERGIC1

RANBP17

Gene ID

57222

64901

Gene nameendoplasmic reticulum-golgi intermediate compartment 1RAN binding protein 17
SynonymsAMCN|ERGIC-32|ERGIC32|NET24-
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionendoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-golgi intermediate compartment (ERGIC) 1endoplasmic reticulum-golgi intermediate compartment 32 kDa proteinran-binding protein 17
Modification date2018052320180523
UniProtAcc

Q969X5

Q9H2T7

Ensembl transtripts involved in fusion geneENST00000393784, ENST00000519860, 
ENST00000523291, ENST00000326654, 
ENST00000523189, ENST00000521759, 
Fusion gene scores* DoF score11 X 13 X 6=8583 X 4 X 4=48
# samples 205
** MAII scorelog2(20/858*10)=-2.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERGIC1 [Title/Abstract] AND RANBP17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERGIC1

GO:0006888

ER to Golgi vesicle-mediated transport

15308636


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-6738-01AERGIC1chr5

172341841

+RANBP17chr5

170720887

+
TCGARVLUSCTCGA-33-6737-01AERGIC1chr5

172341841

+RANBP17chr5

170720887

+
TCGALDOVTCGA-25-2400-01AERGIC1chr5

172351112

+RANBP17chr5

170588411

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393784ENST00000523189ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
5CDS-3UTRENST00000393784ENST00000521759ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
intron-3CDSENST00000519860ENST00000523189ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
intron-3UTRENST00000519860ENST00000521759ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
In-frameENST00000523291ENST00000523189ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
5CDS-3UTRENST00000523291ENST00000521759ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
Frame-shiftENST00000326654ENST00000523189ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
5CDS-3UTRENST00000326654ENST00000521759ERGIC1chr5

172341841

+RANBP17chr5

170720887

+
5CDS-intronENST00000393784ENST00000523189ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
5CDS-intronENST00000393784ENST00000521759ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000519860ENST00000523189ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000519860ENST00000521759ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000523291ENST00000523189ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000523291ENST00000521759ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000326654ENST00000523189ERGIC1chr5

172351112

+RANBP17chr5

170588411

+
intron-intronENST00000326654ENST00000521759ERGIC1chr5

172351112

+RANBP17chr5

170588411

+

Top

FusionProtFeatures for ERGIC1_RANBP17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERGIC1

Q969X5

RANBP17

Q9H2T7

Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000303|PubMed:15308636}. May function as a nuclear transport receptor.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGIC1chr5:172341841chr5:170720887ENST00000393784+5101_26125291Topological domainCytoplasmic
HgeneERGIC1chr5:172341841chr5:170720887ENST00000393784+51027_47125291TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGIC1chr5:172341841chr5:170720887ENST00000326654+131_26-72160Topological domainCytoplasmic
HgeneERGIC1chr5:172341841chr5:170720887ENST00000326654+13276_290-72160Topological domainCytoplasmic
HgeneERGIC1chr5:172341841chr5:170720887ENST00000326654+1348_254-72160Topological domainLumenal
HgeneERGIC1chr5:172341841chr5:170720887ENST00000393784+510276_290125291Topological domainCytoplasmic
HgeneERGIC1chr5:172341841chr5:170720887ENST00000393784+51048_254125291Topological domainLumenal
HgeneERGIC1chr5:172341841chr5:170720887ENST00000326654+13255_275-72160TransmembraneHelical
HgeneERGIC1chr5:172341841chr5:170720887ENST00000326654+1327_47-72160TransmembraneHelical
HgeneERGIC1chr5:172341841chr5:170720887ENST00000393784+510255_275125291TransmembraneHelical


Top

FusionGeneSequence for ERGIC1_RANBP17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_233aa
MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQ
DEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPKQEVLA

>In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_233aa
MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQ
DEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPKQEVLA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_699nt
ATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATC
TGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGAC
CCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAG
GATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAG
TTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTG
GGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCC
CAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGA

>In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_699nt
ATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATC
TGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGAC
CCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAG
GATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAG
TTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTG
GGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCC
CAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_1995nt
GGCGAGTGGCGAGTGGCGAGTGTCAGGGGGGCGGCCGGCGGGGGCGGGGCGGCCGGAGGAGGCGTTGGCAGCGGGCTCGGACCCACGCGG
CGCCGCGGCCCGCCTGGCCTGCAGCGCTCCCACCCCCGGCGGCGGCACGATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGT
GCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATCTGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCT
CACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGACCCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAA
CATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAGGATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTC
CATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAGTTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCAT
TGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTGGGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAG
AGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCCCAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCT
GTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGAAGAGATGTGGCAGAGGCGTTGCGCAGTGATGGCAACACTGA
ACCATGCAGTCTCGACATGATGAGCTGACCCGACTTTTCTGACCATGTGCGGAGCAGCCTTTATCAAGAGACTCCTGAAGGTCTGGGTCT
CAGGACAGTGATGTTGGCTAGCCCAGGGGAATGTATTTTTCAAAACATACAAGCAACAGCAAAAGCCCTAACTTCTTATACGTCTAGCCT
AATTATAAGAATTTCTAACAGTACCAGTGTAAATTCAGTCTTTTCTCTGAAAAGCAAAGGATGTGTTTTCAGTCTTTCTATCAAATATTA
TCTTTGTTCTCCTAATGCTCTGAAAGGATGTAGAAACAATATTTAACCAAAGAACGTAATAAACCAGGTTTGCACCTAAGTGTGTACTAG
TTTATGGTTCTGCAGTCAAGGTTGTCAATTTGTTGGAGATGCAGCCTTCACCATGGATCCTGGATTGAGACGAATGCCATTGGAACCTGT
TAAATGAGTAGTTTGTTATGTGTCTGGAAGAAGCAGCGTTAGGGACTTTGGGCTGTGAGCATTTAGAACGAGCCTGGAAGCACTACAGAG
CATCCCACAGGACCACACGCAGGCCTCCCTGCCTCAGCTGCATCTGATAAAGTTGAGAGACAGTAACACAATTAAATGACTTAGAAACAA
TGTTTGCTTTTCACTGGCATAAATCTGAAGTGGTTCAGTCTAGAAGAATTAAGCTGTGCAATTACTGCCTGCAGAGATATTTCTTCAGGA
GGAGTCATGTAGCCCCAGTCAGAAGTTCTGGGTGGTGCCAGCACCCAGTCCTCTGCCTCCATTTAATTTTTAAGAGAAGGTGAAGGTAAC
TATTAGAATATAATATTTGAAGCAGCTCTGCCTTCTTAGGGCTACCCAAAACAGTTCTAGGTGCTAAAATTCAGATTTTCAGAGGATGAG
AAATAGCTGGTTTCCAACTCTCCACAAAAACTCTTATTACTGTTGGGACTTGGGATTCTGACTCACCCCAAACCCAGAACATGAAGAAGA
CCTTTACAGTTTGTGCTCTACTGTTACTAGGCTATTAATTTGAGATCGTCCACTGTCAAGTGTTTTACTATCTCACTGCTGTTTTTATGA
TTCAGGCTTATAACAAATATTGTATCCTTTATTTCTGATAAGACATGAAAGGTTGGCCTTACTGTTGAACAATAAGTAAATCCACAGGCT

>In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_1859nt
ACGATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCC
ATCTGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGAT
GACCCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATT
CAGGATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGG
CAGTTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTC
CTGGGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTT
GCCCAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTC
AGAAGAGATGTGGCAGAGGCGTTGCGCAGTGATGGCAACACTGAACCATGCAGTCTCGACATGATGAGCTGACCCGACTTTTCTGACCAT
GTGCGGAGCAGCCTTTATCAAGAGACTCCTGAAGGTCTGGGTCTCAGGACAGTGATGTTGGCTAGCCCAGGGGAATGTATTTTTCAAAAC
ATACAAGCAACAGCAAAAGCCCTAACTTCTTATACGTCTAGCCTAATTATAAGAATTTCTAACAGTACCAGTGTAAATTCAGTCTTTTCT
CTGAAAAGCAAAGGATGTGTTTTCAGTCTTTCTATCAAATATTATCTTTGTTCTCCTAATGCTCTGAAAGGATGTAGAAACAATATTTAA
CCAAAGAACGTAATAAACCAGGTTTGCACCTAAGTGTGTACTAGTTTATGGTTCTGCAGTCAAGGTTGTCAATTTGTTGGAGATGCAGCC
TTCACCATGGATCCTGGATTGAGACGAATGCCATTGGAACCTGTTAAATGAGTAGTTTGTTATGTGTCTGGAAGAAGCAGCGTTAGGGAC
TTTGGGCTGTGAGCATTTAGAACGAGCCTGGAAGCACTACAGAGCATCCCACAGGACCACACGCAGGCCTCCCTGCCTCAGCTGCATCTG
ATAAAGTTGAGAGACAGTAACACAATTAAATGACTTAGAAACAATGTTTGCTTTTCACTGGCATAAATCTGAAGTGGTTCAGTCTAGAAG
AATTAAGCTGTGCAATTACTGCCTGCAGAGATATTTCTTCAGGAGGAGTCATGTAGCCCCAGTCAGAAGTTCTGGGTGGTGCCAGCACCC
AGTCCTCTGCCTCCATTTAATTTTTAAGAGAAGGTGAAGGTAACTATTAGAATATAATATTTGAAGCAGCTCTGCCTTCTTAGGGCTACC
CAAAACAGTTCTAGGTGCTAAAATTCAGATTTTCAGAGGATGAGAAATAGCTGGTTTCCAACTCTCCACAAAAACTCTTATTACTGTTGG
GACTTGGGATTCTGACTCACCCCAAACCCAGAACATGAAGAAGACCTTTACAGTTTGTGCTCTACTGTTACTAGGCTATTAATTTGAGAT
CGTCCACTGTCAAGTGTTTTACTATCTCACTGCTGTTTTTATGATTCAGGCTTATAACAAATATTGTATCCTTTATTTCTGATAAGACAT


Top

FusionGenePPI for ERGIC1_RANBP17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERGIC1ERGIC3, FAF2, GNAI2, TOMM7, ATP6V1B1, HIGD1A, ITGA2, NDUFV1, MRPL11, MRPL32, UQCRFS1, IST1, ICT1, GOLGB1, RPA3, RPA2, RPA1, SUZ12, INA, EFNB1, TMED2, NTRK1, SYN1, PRPF4, CTR9, TFG, DUSP22, RDH10, TRIM25RANBP17VPS11, XPO6, SCAI, TRAPPC5, PSPC1, MOV10, NXF1, GYPB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ERGIC1_RANBP17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ERGIC1_RANBP17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource