|
Fusion gene ID: 12000 |
FusionGeneSummary for ERGIC1_RANBP17 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ERGIC1_RANBP17 | Fusion gene ID: 12000 | Hgene | Tgene | Gene symbol | ERGIC1 | RANBP17 | Gene ID | 57222 | 64901 |
Gene name | endoplasmic reticulum-golgi intermediate compartment 1 | RAN binding protein 17 | |
Synonyms | AMCN|ERGIC-32|ERGIC32|NET24 | - | |
Cytomap | 5q35.1 | 5q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | endoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-golgi intermediate compartment (ERGIC) 1endoplasmic reticulum-golgi intermediate compartment 32 kDa protein | ran-binding protein 17 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q969X5 | Q9H2T7 | |
Ensembl transtripts involved in fusion gene | ENST00000393784, ENST00000519860, ENST00000523291, ENST00000326654, | ENST00000523189, ENST00000521759, | |
Fusion gene scores | * DoF score | 11 X 13 X 6=858 | 3 X 4 X 4=48 |
# samples | 20 | 5 | |
** MAII score | log2(20/858*10)=-2.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ERGIC1 [Title/Abstract] AND RANBP17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERGIC1 | GO:0006888 | ER to Golgi vesicle-mediated transport | 15308636 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-33-6738-01A | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
TCGA | RV | LUSC | TCGA-33-6737-01A | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
TCGA | LD | OV | TCGA-25-2400-01A | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000393784 | ENST00000523189 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
5CDS-3UTR | ENST00000393784 | ENST00000521759 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
intron-3CDS | ENST00000519860 | ENST00000523189 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
intron-3UTR | ENST00000519860 | ENST00000521759 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
In-frame | ENST00000523291 | ENST00000523189 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
5CDS-3UTR | ENST00000523291 | ENST00000521759 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
Frame-shift | ENST00000326654 | ENST00000523189 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
5CDS-3UTR | ENST00000326654 | ENST00000521759 | ERGIC1 | chr5 | 172341841 | + | RANBP17 | chr5 | 170720887 | + |
5CDS-intron | ENST00000393784 | ENST00000523189 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
5CDS-intron | ENST00000393784 | ENST00000521759 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000519860 | ENST00000523189 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000519860 | ENST00000521759 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000523291 | ENST00000523189 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000523291 | ENST00000521759 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000326654 | ENST00000523189 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
intron-intron | ENST00000326654 | ENST00000521759 | ERGIC1 | chr5 | 172351112 | + | RANBP17 | chr5 | 170588411 | + |
Top |
FusionProtFeatures for ERGIC1_RANBP17 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ERGIC1 | RANBP17 |
Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000303|PubMed:15308636}. | May function as a nuclear transport receptor.{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000393784 | + | 5 | 10 | 1_26 | 125 | 291 | Topological domain | Cytoplasmic |
Hgene | ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000393784 | + | 5 | 10 | 27_47 | 125 | 291 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000326654 | + | 1 | 3 | 1_26 | -72 | 160 | Topological domain | Cytoplasmic |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000326654 | + | 1 | 3 | 276_290 | -72 | 160 | Topological domain | Cytoplasmic |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000326654 | + | 1 | 3 | 48_254 | -72 | 160 | Topological domain | Lumenal |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000393784 | + | 5 | 10 | 276_290 | 125 | 291 | Topological domain | Cytoplasmic |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000393784 | + | 5 | 10 | 48_254 | 125 | 291 | Topological domain | Lumenal |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000326654 | + | 1 | 3 | 255_275 | -72 | 160 | Transmembrane | Helical |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000326654 | + | 1 | 3 | 27_47 | -72 | 160 | Transmembrane | Helical |
Hgene | >ERGIC1 | chr5:172341841 | chr5:170720887 | ENST00000393784 | + | 5 | 10 | 255_275 | 125 | 291 | Transmembrane | Helical |
Top |
FusionGeneSequence for ERGIC1_RANBP17 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_233aa MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQ DEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPKQEVLA >In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_233aa MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQ DEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPKQEVLA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_699nt ATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATC TGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGAC CCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAG GATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAG TTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTG GGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCC CAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGA >In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_699nt ATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATC TGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGAC CCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAG GATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAG TTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTG GGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCC CAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ERGIC1_ENST00000393784_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_1995nt GGCGAGTGGCGAGTGGCGAGTGTCAGGGGGGCGGCCGGCGGGGGCGGGGCGGCCGGAGGAGGCGTTGGCAGCGGGCTCGGACCCACGCGG CGCCGCGGCCCGCCTGGCCTGCAGCGCTCCCACCCCCGGCGGCGGCACGATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGT GCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCCATCTGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCT CACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGATGACCCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAA CATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATTCAGGATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTC CATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGGCAGTTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCAT TGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTCCTGGGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAG AGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTTGCCCAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCT GTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTCAGAAGAGATGTGGCAGAGGCGTTGCGCAGTGATGGCAACACTGA ACCATGCAGTCTCGACATGATGAGCTGACCCGACTTTTCTGACCATGTGCGGAGCAGCCTTTATCAAGAGACTCCTGAAGGTCTGGGTCT CAGGACAGTGATGTTGGCTAGCCCAGGGGAATGTATTTTTCAAAACATACAAGCAACAGCAAAAGCCCTAACTTCTTATACGTCTAGCCT AATTATAAGAATTTCTAACAGTACCAGTGTAAATTCAGTCTTTTCTCTGAAAAGCAAAGGATGTGTTTTCAGTCTTTCTATCAAATATTA TCTTTGTTCTCCTAATGCTCTGAAAGGATGTAGAAACAATATTTAACCAAAGAACGTAATAAACCAGGTTTGCACCTAAGTGTGTACTAG TTTATGGTTCTGCAGTCAAGGTTGTCAATTTGTTGGAGATGCAGCCTTCACCATGGATCCTGGATTGAGACGAATGCCATTGGAACCTGT TAAATGAGTAGTTTGTTATGTGTCTGGAAGAAGCAGCGTTAGGGACTTTGGGCTGTGAGCATTTAGAACGAGCCTGGAAGCACTACAGAG CATCCCACAGGACCACACGCAGGCCTCCCTGCCTCAGCTGCATCTGATAAAGTTGAGAGACAGTAACACAATTAAATGACTTAGAAACAA TGTTTGCTTTTCACTGGCATAAATCTGAAGTGGTTCAGTCTAGAAGAATTAAGCTGTGCAATTACTGCCTGCAGAGATATTTCTTCAGGA GGAGTCATGTAGCCCCAGTCAGAAGTTCTGGGTGGTGCCAGCACCCAGTCCTCTGCCTCCATTTAATTTTTAAGAGAAGGTGAAGGTAAC TATTAGAATATAATATTTGAAGCAGCTCTGCCTTCTTAGGGCTACCCAAAACAGTTCTAGGTGCTAAAATTCAGATTTTCAGAGGATGAG AAATAGCTGGTTTCCAACTCTCCACAAAAACTCTTATTACTGTTGGGACTTGGGATTCTGACTCACCCCAAACCCAGAACATGAAGAAGA CCTTTACAGTTTGTGCTCTACTGTTACTAGGCTATTAATTTGAGATCGTCCACTGTCAAGTGTTTTACTATCTCACTGCTGTTTTTATGA TTCAGGCTTATAACAAATATTGTATCCTTTATTTCTGATAAGACATGAAAGGTTGGCCTTACTGTTGAACAATAAGTAAATCCACAGGCT >In-frame_ERGIC1_ENST00000523291_chr5_172341841_+_RANBP17_ENST00000523189_chr5_170720887_+_1859nt ACGATGCCCTTTGACTTCAGGAGGTTTGACATCTACAGGAAGGTGCCCAAGGACCTTACGCAGCCAACGTACACCGGGGCCATTATCTCC ATCTGCTGCTGCCTCTTCATCCTCTTCCTCTTCCTCTCGGAGCTCACCGGATTTATAACGACAGAAGTTGTGAACGAGCTCTATGTCGAT GACCCAGACAAGGACAGCGGTGGCAAGATCGACGTCAGTCTGAACATCAGTTTACCCAATCTGCACTGCGAGTTGGTTGGGCTTGACATT CAGGATGAGATGGGCAGGCACGAAGTGGGCCACATCGACAACTCCATGAAGATCCCGCTGAACAATGGGGCAGGCTGCCGCTTCGAGGGG CAGTTCAGCATCAACAAGATGATGTCTGTCCTCATGAACACCATTGTCTTTGAAGACTGTCGGAACCAGTGGTCAGTATCCAGGCCTCTC CTGGGGCTCATCCTGCTCAATGAGAAGTATTTCAGTGAACTGAGAGCAAGTTTGATAAACAGCCAGCCCCTCCCCAAGCAGGAGGTCCTT GCCCAGTGCTTCAGAAACCTAATGGAAGGAGTGGAGCAGAACCTGTCCGTCAAGAACAGAGACAGGTTCACCCAAAATCTGTCTGTATTC AGAAGAGATGTGGCAGAGGCGTTGCGCAGTGATGGCAACACTGAACCATGCAGTCTCGACATGATGAGCTGACCCGACTTTTCTGACCAT GTGCGGAGCAGCCTTTATCAAGAGACTCCTGAAGGTCTGGGTCTCAGGACAGTGATGTTGGCTAGCCCAGGGGAATGTATTTTTCAAAAC ATACAAGCAACAGCAAAAGCCCTAACTTCTTATACGTCTAGCCTAATTATAAGAATTTCTAACAGTACCAGTGTAAATTCAGTCTTTTCT CTGAAAAGCAAAGGATGTGTTTTCAGTCTTTCTATCAAATATTATCTTTGTTCTCCTAATGCTCTGAAAGGATGTAGAAACAATATTTAA CCAAAGAACGTAATAAACCAGGTTTGCACCTAAGTGTGTACTAGTTTATGGTTCTGCAGTCAAGGTTGTCAATTTGTTGGAGATGCAGCC TTCACCATGGATCCTGGATTGAGACGAATGCCATTGGAACCTGTTAAATGAGTAGTTTGTTATGTGTCTGGAAGAAGCAGCGTTAGGGAC TTTGGGCTGTGAGCATTTAGAACGAGCCTGGAAGCACTACAGAGCATCCCACAGGACCACACGCAGGCCTCCCTGCCTCAGCTGCATCTG ATAAAGTTGAGAGACAGTAACACAATTAAATGACTTAGAAACAATGTTTGCTTTTCACTGGCATAAATCTGAAGTGGTTCAGTCTAGAAG AATTAAGCTGTGCAATTACTGCCTGCAGAGATATTTCTTCAGGAGGAGTCATGTAGCCCCAGTCAGAAGTTCTGGGTGGTGCCAGCACCC AGTCCTCTGCCTCCATTTAATTTTTAAGAGAAGGTGAAGGTAACTATTAGAATATAATATTTGAAGCAGCTCTGCCTTCTTAGGGCTACC CAAAACAGTTCTAGGTGCTAAAATTCAGATTTTCAGAGGATGAGAAATAGCTGGTTTCCAACTCTCCACAAAAACTCTTATTACTGTTGG GACTTGGGATTCTGACTCACCCCAAACCCAGAACATGAAGAAGACCTTTACAGTTTGTGCTCTACTGTTACTAGGCTATTAATTTGAGAT CGTCCACTGTCAAGTGTTTTACTATCTCACTGCTGTTTTTATGATTCAGGCTTATAACAAATATTGTATCCTTTATTTCTGATAAGACAT |
Top |
FusionGenePPI for ERGIC1_RANBP17 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ERGIC1 | ERGIC3, FAF2, GNAI2, TOMM7, ATP6V1B1, HIGD1A, ITGA2, NDUFV1, MRPL11, MRPL32, UQCRFS1, IST1, ICT1, GOLGB1, RPA3, RPA2, RPA1, SUZ12, INA, EFNB1, TMED2, NTRK1, SYN1, PRPF4, CTR9, TFG, DUSP22, RDH10, TRIM25 | RANBP17 | VPS11, XPO6, SCAI, TRAPPC5, PSPC1, MOV10, NXF1, GYPB |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ERGIC1_RANBP17 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ERGIC1_RANBP17 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |