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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11974

FusionGeneSummary for ERCC1_FN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERCC1_FN1
Fusion gene ID: 11974
HgeneTgene
Gene symbol

ERCC1

FN1

Gene ID

2067

2335

Gene nameERCC excision repair 1, endonuclease non-catalytic subunitfibronectin 1
SynonymsCOFS4|RAD10|UV20CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF
Cytomap

19q13.32

2q35

Type of geneprotein-codingprotein-coding
DescriptionDNA excision repair protein ERCC-1excision repair cross-complementation group 1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)fibronectincold-insoluble globulinmigration-stimulating factor
Modification date2018052320180527
UniProtAcc

P07992

P02751

Ensembl transtripts involved in fusion geneENST00000300853, ENST00000423698, 
ENST00000588738, ENST00000340192, 
ENST00000591636, ENST00000589165, 
ENST00000013807, 
ENST00000421182, 
ENST00000357867, ENST00000323926, 
ENST00000336916, ENST00000354785, 
ENST00000357009, ENST00000346544, 
ENST00000345488, ENST00000359671, 
ENST00000446046, ENST00000443816, 
ENST00000432072, ENST00000356005, 
ENST00000490833, ENST00000426059, 
Fusion gene scores* DoF score5 X 6 X 2=6020 X 22 X 3=1320
# samples 626
** MAII scorelog2(6/60*10)=0log2(26/1320*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERCC1 [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERCC1

GO:0006289

nucleotide-excision repair

3290851

TgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

TgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

TgeneFN1

GO:0010628

positive regulation of gene expression

25834989

TgeneFN1

GO:0018149

peptide cross-linking

3997886

TgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneFN1

GO:0035987

endodermal cell differentiation

23154389

TgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

TgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

TgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

TgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

TgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

TgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF809968ERCC1chr19

45975895

+FN1chr2

216273026

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000300853ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000300853ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000423698ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000588738ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000340192ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000591636ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000589165ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000421182ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000357867ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000323926ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000336916ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000354785ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000357009ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000346544ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000345488ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000359671ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000446046ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000443816ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000432072ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000356005ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000490833ERCC1chr19

45975895

+FN1chr2

216273026

+
intron-intronENST00000013807ENST00000426059ERCC1chr19

45975895

+FN1chr2

216273026

+

Top

FusionProtFeatures for ERCC1_FN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERCC1

P07992

FN1

P02751

Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incisionduring DNA repair. Responsible, in conjunction with SLX4, for thefirst step in the repair of interstrand cross-links (ICL).Participates in the processing of anaphase bridge-generating DNAstructures, which consist in incompletely processed DNA lesionsarising during S or G2 phase, and can result in cytokinesisfailure. Also required for homology-directed repair (HDR) of DNAdouble-strand breaks, in conjunction with SLX4.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERCC1_FN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ERCC1_FN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ERCC1_FN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
TgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational

Top

RelatedDiseases for ERCC1_FN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERCC1C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneERCC1C0001956alcohol use disorder1PSYGENET
HgeneERCC1C0007873Uterine Cervical Neoplasm1CTD_human
HgeneERCC1C0008625Chromosome Aberrations1CTD_human
HgeneERCC1C0025202melanoma1CTD_human
HgeneERCC1C0027627Neoplasm Metastasis1CTD_human
HgeneERCC1C0027658Neoplasms, Germ Cell and Embryonal1CTD_human
HgeneERCC1C0031117Peripheral Neuropathy1CTD_human
HgeneERCC1C0038356Stomach Neoplasms1CTD_human
HgeneERCC1C0039590Testicular Neoplasms1CTD_human
HgeneERCC1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneERCC1C0311375Arsenic Poisoning1CTD_human
HgeneERCC1C1853100CEREBROOCULOFACIOSKELETAL SYNDROME 41CTD_human;UNIPROT
HgeneERCC1C2931822Nasopharyngeal carcinoma1CTD_human
TgeneFN1C0020538Hypertensive disease2CTD_human;HPO
TgeneFN1C0000786Spontaneous abortion1CTD_human
TgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
TgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
TgeneFN1C0010346Crohn Disease1CTD_human
TgeneFN1C0011849Diabetes Mellitus1CTD_human
TgeneFN1C0011881Diabetic Nephropathy1CTD_human
TgeneFN1C0017636Glioblastoma1CTD_human
TgeneFN1C0017668Focal glomerulosclerosis1CTD_human
TgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
TgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneFN1C0027626Neoplasm Invasiveness1CTD_human
TgeneFN1C0034069Pulmonary Fibrosis1CTD_human
TgeneFN1C0036341Schizophrenia1PSYGENET
TgeneFN1C0085762Alcohol abuse1PSYGENET
TgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneFN1C0345967Malignant mesothelioma1CTD_human
TgeneFN1C1458155Mammary Neoplasms1CTD_human
TgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT