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Fusion gene ID: 11968 |
FusionGeneSummary for ERC2_ARHGEF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERC2_ARHGEF3 | Fusion gene ID: 11968 | Hgene | Tgene | Gene symbol | ERC2 | ARHGEF3 | Gene ID | 26059 | 50650 |
| Gene name | ELKS/RAB6-interacting/CAST family member 2 | Rho guanine nucleotide exchange factor 3 | |
| Synonyms | CAST|CAST1|ELKSL|SPBC110|Spc110 | GEF3|STA3|XPLN | |
| Cytomap | 3p14.3 | 3p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ERC protein 2CAZ-associated structural proteincytomatrix protein p110 | rho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLN | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O15083 | Q9NR81 | |
| Ensembl transtripts involved in fusion gene | ENST00000288221, ENST00000486496, | ENST00000338458, ENST00000496106, ENST00000498517, ENST00000296315, ENST00000413728, ENST00000497267, ENST00000495373, | |
| Fusion gene scores | * DoF score | 3 X 4 X 4=48 | 4 X 4 X 5=80 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERC2 [Title/Abstract] AND ARHGEF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SO-01A | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| TCGA | LD | OV | TCGA-61-2092-01A | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000288221 | ENST00000338458 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| In-frame | ENST00000288221 | ENST00000496106 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5CDS-5UTR | ENST00000288221 | ENST00000498517 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5CDS-intron | ENST00000288221 | ENST00000296315 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5CDS-intron | ENST00000288221 | ENST00000413728 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5CDS-intron | ENST00000288221 | ENST00000497267 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5CDS-intron | ENST00000288221 | ENST00000495373 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-3CDS | ENST00000486496 | ENST00000338458 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-3CDS | ENST00000486496 | ENST00000496106 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-5UTR | ENST00000486496 | ENST00000498517 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-intron | ENST00000486496 | ENST00000296315 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-intron | ENST00000486496 | ENST00000413728 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-intron | ENST00000486496 | ENST00000497267 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| intron-intron | ENST00000486496 | ENST00000495373 | ERC2 | chr3 | 56468379 | - | ARHGEF3 | chr3 | 56916382 | - |
| 5UTR-3CDS | ENST00000288221 | ENST00000338458 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000496106 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000498517 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000296315 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000413728 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000497267 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| 5UTR-intron | ENST00000288221 | ENST00000495373 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-3CDS | ENST00000486496 | ENST00000338458 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000496106 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000498517 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000296315 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000413728 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000497267 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
| intron-intron | ENST00000486496 | ENST00000495373 | ERC2 | chr3 | 56502276 | - | ARHGEF3 | chr3 | 56992917 | - |
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FusionProtFeatures for ERC2_ARHGEF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERC2 | ARHGEF3 |
| Thought to be involved in the organization of thecytomatrix at the nerve terminals active zone (CAZ) whichregulates neurotransmitter release. Seems to act together withBSN. May recruit liprin-alpha proteins to the CAZ. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ERC2 | chr3:56468379 | chr3:56916382 | ENST00000288221 | - | 2 | 18 | 129_133 | 219 | 1665 | Compositional bias | Note=Poly-His |
| Hgene | ERC2 | chr3:56468379 | chr3:56916382 | ENST00000288221 | - | 2 | 18 | 35_41 | 219 | 1665 | Compositional bias | Note=Poly-Gly |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000296315 | - | 0 | 10 | 122_304 | -57 | 527 | Domain | DH |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000296315 | - | 0 | 10 | 291_449 | -57 | 527 | Domain | PH |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000338458 | - | 2 | 13 | 122_304 | 43 | 559 | Domain | DH |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000338458 | - | 2 | 13 | 291_449 | 43 | 559 | Domain | PH |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000413728 | - | 0 | 10 | 122_304 | -182 | 533 | Domain | DH |
| Tgene | >ARHGEF3 | chr3:56468379 | chr3:56916382 | ENST00000413728 | - | 0 | 10 | 291_449 | -182 | 533 | Domain | PH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ERC2 | chr3:56468379 | chr3:56916382 | ENST00000288221 | - | 2 | 18 | 140_917 | 219 | 1665 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ERC2 | chr3:56468379 | chr3:56916382 | ENST00000288221 | - | 2 | 18 | 879_882 | 219 | 1665 | Compositional bias | Note=Poly-Lys |
| Hgene | >ERC2 | chr3:56468379 | chr3:56916382 | ENST00000288221 | - | 2 | 18 | 920_932 | 219 | 1665 | Compositional bias | Note=Poly-His |
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FusionGeneSequence for ERC2_ARHGEF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000338458_chr3_56916382_-_735aa MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAV YGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKR FSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCL ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGS QSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000496106_chr3_56916382_-_735aa MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAV YGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKR FSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCL ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGS QSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000338458_chr3_56916382_-_2205nt ATGTATGGAAGTGCAAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGA AGAACAAGTAGTGGGGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGA CCCATGTATCTGAGTGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTA TATGGAGGCCGTGTCACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAA CATGGTGGGCTGACTGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTT CAGGCCCAGCTGAAAGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAAC AGTATTAAGACTTTCTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAG ATGAGGGTTTCCCATGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGT GAGCCTAGTAATAAACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGC TTCAGTCAAACCCTGCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCC CCCTCGAGCACGAAACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAA CGTCAGGAGGCGATCTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATG CTGAAACTCTCCATAATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGT CAGCTTCGAGATGTTAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGAT AGCTACTGCAGCAATCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTA GAATCCCCCTTTAGCCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAA ATCTTGAGGCACACACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAAC ACCAAGACTGGTGAATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCT CGAGTCTTGTGTTGTCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGA GCCGTCACCCACAATGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGA GAAGTGAGGCTGGGTGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCC CAAAGTCAGACCCACTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTG TGTGCTGCCGGGCAAGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAA CTTGAGCAGATGGACCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACA >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000496106_chr3_56916382_-_2205nt ATGTATGGAAGTGCAAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGA AGAACAAGTAGTGGGGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGA CCCATGTATCTGAGTGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTA TATGGAGGCCGTGTCACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAA CATGGTGGGCTGACTGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTT CAGGCCCAGCTGAAAGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAAC AGTATTAAGACTTTCTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAG ATGAGGGTTTCCCATGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGT GAGCCTAGTAATAAACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGC TTCAGTCAAACCCTGCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCC CCCTCGAGCACGAAACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAA CGTCAGGAGGCGATCTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATG CTGAAACTCTCCATAATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGT CAGCTTCGAGATGTTAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGAT AGCTACTGCAGCAATCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTA GAATCCCCCTTTAGCCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAA ATCTTGAGGCACACACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAAC ACCAAGACTGGTGAATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCT CGAGTCTTGTGTTGTCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGA GCCGTCACCCACAATGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGA GAAGTGAGGCTGGGTGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCC CAAAGTCAGACCCACTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTG TGTGCTGCCGGGCAAGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAA CTTGAGCAGATGGACCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000338458_chr3_56916382_-_4313nt GCTCGCTCGGTCTCCGGCTCCGGCGCCGGCTCCTGCTCCTCCTGGCCGCCCGGGGCCAAGGCGACGAGAGGTTGTAAAAATCCATGTGGG ACGGCCCCGGGGCGAGCATCGGAAAGATCTCTGAGTGGAGTTATTTTCTGGTACGGACTGTGAAAAGAATGCGGTGAAAATTCTGGACAA TCGTGGAAATATTAGCTCAAACCCCAACTTAATATAGCATTTCTTCTCTTCAGTAACACCTCATAATACAAGAAAAATGTATGGAAGTGC AAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGAAGAACAAGTAGTGG GGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGACCCATGTATCTGAG TGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTATATGGAGGCCGTGT CACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAACATGGTGGGCTGAC TGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTTCAGGCCCAGCTGAA AGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAACAGTATTAAGACTTT CTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAGATGAGGGTTTCCCA TGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGAGCCTAGTAATAA ACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGCTTCAGTCAAACCCT GCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCCCCCTCGAGCACGAA ACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAACGTCAGGAGGCGAT CTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATGCTGAAACTCTCCAT AATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGTCAGCTTCGAGATGT TAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGATAGCTACTGCAGCAA TCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTAGAATCCCCCTTTAG CCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAAATCTTGAGGCACAC ACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAACACCAAGACTGGTGA ATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCTCGAGTCTTGTGTTG TCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGAGCCGTCACCCACAA TGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGAGAAGTGAGGCTGGG TGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCCCAAAGTCAGACCCA CTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTGTGTGCTGCCGGGCA AGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAACTTGAGCAGATGGA CCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACAGACTCTTCCTGTGG AAACAGCAGGCACGGTGAAAGTAACGTCTGACAGAAGCATGTGCACTTCGGGAAGCAGGCCTGCATCTTACCTGTACAGTATTTGCATTC CACAGATGGAACGGTTTGGAGAAGCACTTTTTCATACTTTTGTGAAAGTATACATGTTGGCCCAGTCTCTCGTATCTGTACCTTTGTCCC TAGTACTGTAACTGCCAATCTGTCTGTGTAAGCTGGAATCTGTGGCAACTATTACCCTGTGTTGTATTTCCCAAGTGTCTGGATGGATGG AGAGGTACTCAAACAAGTTACTTTCAGTTGTCCTGCTGGATTTTAAAAAAATAGAAAAAGAATCTCAAAACTACTGTTTTACATAGATTG TTTGAAGAGTCCTTCCTCTTGTGCTTCTGTACCACTTTCCCAGCTCTTAGATGTGGTAGCTAAAGGCACGGAATTTAGACGGCCTTGTAA ATAGGGCATGAGGAACTCATCTGTGTATTGGGATGGTATTAGAGAGAGAATCAGGAAAGACCAACTCATGAAGTGAACTTGGTTTGATCT TACTCAACTAGAAAGCTTGAAAACATCCCTGGGGATTCTGAAGGCTTAATTTTGCAAAGGAGGATGCATTGTCTGAACTTTGCAACTTCA TCCAGTGCAAGTTTGATGCAAGAATGTATTAGGACATAAAATAGAGGCTGACCTTAAAAGGGCCAGGACAGAAGCGGCTGCCAGCTCTGA ATCTTTAACTGAAATGCACATGGCACCAGGAGGTGTCTCTCATAGTTGGTTGCTAGCCTAAAACATCAGAATAGAACCCAAAGGGCTTAG GAAGGCCTGCCAGGATAACAAGAAGGCCCTGTATTCATTGTGTTTCATCTGCCTAGGCCTACTCATTATTTTAGAGAATGAATGAAGCAA CAAGGAAGAGAGACCATGACTCTATCGATGACACTGTTTATAGAAACACAGGAGAGGAAGAATTTGGAATGAAAAGCACTTCGTCAGAAC CTTCTGTGGGAGCCATTGAGAGAAAAGCATGGTCCAGTGCCTTCTGAGAAAGGCCAGAGCTTTGGGCTTTCCTGCTCTGCTTTTGGGTCG TCAATTTGCCATCTCTGGTTCTGTGCTATAATCAGAATTGTAATTATGTTCTCCAGAGGCCAATTTCATTAACTCTGATTAATTAGAATC AGCTAGCCAGATTAGTAACCTCTTTGTCCAGCCTTGATTTACAGTGCAGGGTAAAGTGCAGACCTTAAAAACAGCTAAGTACCTAGAAGA GCTCCCTGCAAGTGTAAATATTAAGGATGACCTGTGCAAAATTATACCCACACCAGCACTAGTGGTAATTATTCTAAATTATTGCCAAAA AGTTTTTTTTAATCTGTCTTTCAAGTTTACAGAAAAGAAAGCAGTAAATGCATTGATGTCATTTTATTATGTACATATATCATGTGCATT CAAGCTGTGTGACAAGATATATCAATATAAAAACAAGGTATATACTTTATTATTTTTTGAAAACAAGGATATTGTGATCAATTTTACCCT GTAAAACATATTTCTGTATTTATAGGTCTTAAACATGATGAATTTTTTCTATTACAAGTTTATTTAAAACTGCTTTCTCAAGTCGTTATT GATACAGCAAGTGAACCTGCTGCAGACAGAAGCAGAGGAAAGCCAAGAACAGCCTTTATTGGTGAAGAAAAGAATGAATGATTCTTTGTA GGCGCCATCAGCCACTTTTAGAAGCCATCAGCCAGTGTGTTGGGAAAAGAGGTTTGTCAAGTGTTGGCCTATGGGAAGGTGGTCAATGAA >In-frame_ERC2_ENST00000288221_chr3_56468379_-_ARHGEF3_ENST00000496106_chr3_56916382_-_2744nt GCTCGCTCGGTCTCCGGCTCCGGCGCCGGCTCCTGCTCCTCCTGGCCGCCCGGGGCCAAGGCGACGAGAGGTTGTAAAAATCCATGTGGG ACGGCCCCGGGGCGAGCATCGGAAAGATCTCTGAGTGGAGTTATTTTCTGGTACGGACTGTGAAAAGAATGCGGTGAAAATTCTGGACAA TCGTGGAAATATTAGCTCAAACCCCAACTTAATATAGCATTTCTTCTCTTCAGTAACACCTCATAATACAAGAAAAATGTATGGAAGTGC AAGAACAATCACCAATCTGGAAGGTAGCCCTTCCAGATCCCCTCGTTTGCCAAGGTCTCCTCGTTTGGGCCACCGAAGAACAAGTAGTGG GGGAGGTGGAGGAACAGGCAAGACTCTGTCTATGGAGAATATCCAGTCCCTCAATGCAGCCTATGCTACGTCTGGACCCATGTATCTGAG TGATCATGAAGGGGTGGCTTCAACAACCTACCCAAAGGGCACTATGACTCTGGGAAGGGCTACAAATCGAGCTGTATATGGAGGCCGTGT CACAGCCATGGGGAGTAGTCCCAATATTGCTTCTGCTGGACTTTCCCACACAGATGTCCTTTCATACACAGATCAACATGGTGGGCTGAC TGGCTCATCCCATCATCACCACCACCAGGTCCCCTCCATGTTGAGGCAGGTAAGAGACAGCACAATGTTAGATCTTCAGGCCCAGCTGAA AGAACTGCAGAGAGAGAATGACCTCCTCCGGAAAGAGCTAGACATCAAGGACAGCAAATTGGGATCTTCCATGAACAGTATTAAGACTTT CTGGAGTCCTGAGCTTAAGAAGGAGAGAGTCTTGAGGAAAGAAGAGGCAGCGCGGATGTCTGTCCTCAAGGAGCAGATGAGGGTTTCCCA TGAAGAAAATCAGCGAAAACGGAAACAGAGCACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGAGCCTAGTAATAA ACGGGTCAAACCCCTTTCCCGAGTCACGTCGCTAGCAAACCTCATCCCGCCCGTGAAGGCCACGCCATTAAAGCGCTTCAGTCAAACCCT GCAGCGCTCCATTAGCTTCCGCAGTGAGAGCCGCCCTGACATCCTCGCCCCCCGACCCTGGTCCAGAAATGCCGCCCCCTCGAGCACGAA ACGGAGAGATAGCAAGCTGTGGAGTGAGACCTTCGATGTGTGCGTCAATCAGATGCTTACATCCAAGGAAATCAAACGTCAGGAGGCGAT CTTTGAGCTTTCCCAAGGAGAAGAAGACTTGATAGAAGACTTGAAATTAGCAAAAAAGGCCTATCATGACCCCATGCTGAAACTCTCCAT AATGACAGAACAAGAGTTGAATCAAATTTTTGGAACACTGGACTCTCTAATTCCTCTACATGAAGAGCTCCTTAGTCAGCTTCGAGATGT TAGGAAGCCTGATGGCTCGACTGAACATGTTGGTCCCATCCTCGTGGGCTGGCTCCCTTGCCTCAGCTCCTATGATAGCTACTGCAGCAA TCAAGTAGCCGCCAAAGCTCTGCTGGACCACAAAAAGCAAGATCACCGAGTCCAGGATTTCCTACAGCGATGTTTAGAATCCCCCTTTAG CCGCAAACTAGATCTCTGGAATTTCCTCGATATTCCAAGAAGCCGCCTGGTAAAATACCCTCTGCTTCTCCGAGAAATCTTGAGGCACAC ACCAAATGATAATCCAGATCAGCAGCACTTGGAAGAAGCTATAAATATCATTCAGGGAATTGTGGCAGAAATCAACACCAAGACTGGTGA ATCTGAATGCCGCTATTATAAAGAGCGGCTTCTTTACTTGGAAGAAGGCCAGAAAGACTCCCTGATCGACAGCTCTCGAGTCTTGTGTTG TCATGGTGAACTGAAGAACAATCGGGGCGTGAAACTGCATGTTTTCCTGTTCCAAGAAGTGCTTGTGATCACTCGAGCCGTCACCCACAA TGAGCAGCTTTGCTACCAGCTGTACCGTCAGCCAATCCCCGTGAAAGACCTCCTGCTGGAAGACCTCCAGGATGGAGAAGTGAGGCTGGG TGGCTCCCTGCGAGGGGCATTCAGCAACAATGAGAGAATTAAAAACTTCTTCAGAGTCAGTTTCAAAAATGGATCCCAAAGTCAGACCCA CTCGCTACAAGCCAATGACACTTTCAACAAACAGCAGTGGCTTAACTGTATTCGTCAAGCCAAAGAAACAGTTTTGTGTGCTGCCGGGCA AGCTGGGGTGCTTGACTCCGAGGGATCGTTCCTAAATCCCACCACCGGGAGCAGAGAGCTACAGGGAGAAACAAAACTTGAGCAGATGGA CCAATCGGACAGTGAGTCAGACTGTAGTATGGACACGAGTGAGGTCAGCCTCGACTGTGAGCGCATGGAACAGACAGACTCTTCCTGTGG AAACAGCAGGCACGGTGAAAGTAACGTCTGACAGAAGCATGTGCACTTCGGGAAGCAGGCCTGCATCTTACCTGTACAGTATTTGCATTC CACAGATGGAACGGTTTGGAGAAGCACTTTTTCATACTTTTGTGAAAGTATACATGTTGGCCCAGTCTCTCGTATCTGTACCTTTGTCCC TAGTACTGTAACTGCCAATCTGTCTGTGTAAGCTGGAATCTGTGGCAACTATTACCCTGTGTTGTATTTCCCAAGTGTCTGGATGGATGG |
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FusionGenePPI for ERC2_ARHGEF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ERC2 | PPFIA1, PPFIA4, BSN, RIMS1, UNC13A, PCLO, PPFIA2, PPFIA3, GIT1, GRIP2, LSP1, ERC1, IQCB1, MYB, DGUOK | ARHGEF3 | RHOA, RHOB, TRIM23, TRIM27, CEP70, SHMT2, NXF1, XPO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERC2_ARHGEF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERC2_ARHGEF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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