|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1194 |
FusionGeneSummary for AHCYL2_YME1L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHCYL2_YME1L1 | Fusion gene ID: 1194 | Hgene | Tgene | Gene symbol | AHCYL2 | YME1L1 | Gene ID | 23382 | 10730 |
| Gene name | adenosylhomocysteinase like 2 | YME1 like 1 ATPase | |
| Synonyms | ADOHCYASE3|IRBIT2 | FTSH|MEG4|OPA11|PAMP|YME1L | |
| Cytomap | 7q32.1 | 10p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3 | ATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloprotease | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96HN2 | Q96TA2 | |
| Ensembl transtripts involved in fusion gene | ENST00000325006, ENST00000446544, ENST00000531335, ENST00000474594, ENST00000446212, ENST00000490911, ENST00000472554, | ENST00000326799, ENST00000376016, ENST00000375972, ENST00000463270, ENST00000477432, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 6 X 3=108 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AHCYL2 [Title/Abstract] AND YME1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YME1L1 | GO:0034214 | protein hexamerization | 27786171 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA731128 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - | ||
| ChiTaRS3.1 | AK309708 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000325006 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000325006 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000325006 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000325006 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000325006 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446544 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446544 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446544 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000446544 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000446544 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000531335 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000531335 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000531335 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000531335 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000531335 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000474594 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000474594 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000474594 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000474594 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000474594 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446212 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446212 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000446212 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000446212 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000446212 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000490911 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000490911 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000490911 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000490911 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000490911 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000472554 | ENST00000326799 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000472554 | ENST00000376016 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-3CDS | ENST00000472554 | ENST00000375972 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000472554 | ENST00000463270 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
| intron-intron | ENST00000472554 | ENST00000477432 | AHCYL2 | chr7 | 129050161 | - | YME1L1 | chr10 | 27425291 | - |
Top |
FusionProtFeatures for AHCYL2_YME1L1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHCYL2 | YME1L1 |
| May regulate the electrogenic sodium/bicarbonatecotransporter SLC4A4 activity and Mg(2+)-sensitivity. On thecontrary of its homolog AHCYL1, does not regulate ITPR1sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).{ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. | ATP-dependent metalloprotease that catalyzes thedegradation of folded and unfolded proteins with a suitable degronsequence in the mitochondrial intermembrane region(PubMed:26923599, PubMed:27786171). Plays an important role inregulating mitochondrial morphology and function by cleaving OPA1at position S2, giving rise to a form of OPA1 that promotesmaintenance of normal mitochondrial structure and mitochondrialprotein metabolism (PubMed:18076378, PubMed:26923599,PubMed:27495975). Ensures cell proliferation, maintains normalcristae morphology and complex I respiration activity, promotesantiapoptotic activity and protects mitochondria from theaccumulation of oxidatively damaged membrane proteins(PubMed:22262461). Required for normal, constitutive degradationof PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 inresponse to membrane depolarization (PubMed:26923599). Required tocontrol the accumulation of nonassembled respiratory chainsubunits (NDUFB6, OX4 and ND1) (PubMed:22262461).{ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461,ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975,ECO:0000269|PubMed:27786171}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for AHCYL2_YME1L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for AHCYL2_YME1L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for AHCYL2_YME1L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for AHCYL2_YME1L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AHCYL2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|