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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11936

FusionGeneSummary for ERBB3_MICAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB3_MICAL3
Fusion gene ID: 11936
HgeneTgene
Gene symbol

ERBB3

MICAL3

Gene ID

2065

57553

Gene nameerb-b2 receptor tyrosine kinase 3microtubule associated monooxygenase, calponin and LIM domain containing 3
SynonymsErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3MICAL-3
Cytomap

12q13.2

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3[F-actin]-monooxygenase MICAL3F-actin-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3
Modification date2018052720180519
UniProtAcc

P21860

Q7RTP6

Ensembl transtripts involved in fusion geneENST00000267101, ENST00000450146, 
ENST00000415288, ENST00000553131, 
ENST00000411731, ENST00000549832, 
ENST00000441493, ENST00000400561, 
ENST00000444520, ENST00000414725, 
ENST00000383094, ENST00000207726, 
ENST00000429452, ENST00000585038, 
ENST00000580469, 
Fusion gene scores* DoF score16 X 15 X 9=21603 X 3 X 1=9
# samples 163
** MAII scorelog2(16/2160*10)=-3.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERBB3 [Title/Abstract] AND MICAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB3

GO:0007162

negative regulation of cell adhesion

7556068

HgeneERBB3

GO:0007165

signal transduction

10572067

HgeneERBB3

GO:0009968

negative regulation of signal transduction

11389077

HgeneERBB3

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB3

GO:0042127

regulation of cell proliferation

11389077

HgeneERBB3

GO:0051048

negative regulation of secretion

10559227

TgeneMICAL3

GO:0007010

cytoskeleton organization

24440334

TgeneMICAL3

GO:0030042

actin filament depolymerization

24440334


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG983587ERBB3chr12

56493959

-MICAL3chr22

18473830

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000267101ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000267101ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000450146ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000415288ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000553131ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000411731ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000441493ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000400561ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000444520ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000414725ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000383094ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000207726ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000429452ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000585038ERBB3chr12

56493959

-MICAL3chr22

18473830

+
intron-intronENST00000549832ENST00000580469ERBB3chr12

56493959

-MICAL3chr22

18473830

+

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FusionProtFeatures for ERBB3_MICAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB3

P21860

MICAL3

Q7RTP6

Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. Monooxygenase that promotes depolymerization of F-actinby mediating oxidation of specific methionine residues on actin toform methionine-sulfoxide, resulting in actin filament disassemblyand preventing repolymerization. In the absence of actin, it alsofunctions as a NADPH oxidase producing H(2)O(2). Seems to act asRab effector protein and plays a role in vesicle trafficking.Involved in exocytic vesicles tethering and fusion: themonooxygenase activity is required for this process and implicatesRAB8A associated with exocytotic vesicles. Required forcytokinesis. Contributes to stabilization and/or maturation of theintercellular bridge independently of its monooxygenase activity.Promotes recruitment of Rab8 and ERC1 to the intercellular bridge,and together these proteins are proposed to function in timelyabscission. {ECO:0000269|PubMed:21596566,ECO:0000269|PubMed:24440334}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERBB3_MICAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERBB3_MICAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERBB3_MICAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERBB3_MICAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERBB3C0036341Schizophrenia3PSYGENET
HgeneERBB3C0005586Bipolar Disorder1PSYGENET
HgeneERBB3C0011570Mental Depression1PSYGENET
HgeneERBB3C0016978gallbladder neoplasm1CTD_human
HgeneERBB3C0024121Lung Neoplasms1CTD_human
HgeneERBB3C0033578Prostatic Neoplasms1CTD_human
HgeneERBB3C0041696Unipolar Depression1PSYGENET
HgeneERBB3C1269683Major Depressive Disorder1PSYGENET
HgeneERBB3C1458155Mammary Neoplasms1CTD_human
HgeneERBB3C2931822Nasopharyngeal carcinoma1CTD_human