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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11897

FusionGeneSummary for ERBB2IP_PPWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB2IP_PPWD1
Fusion gene ID: 11897
HgeneTgene
Gene symbol

ERBB2IP

PPWD1

Gene ID

55914

23398

Gene nameerbb2 interacting proteinpeptidylprolyl isomerase domain and WD repeat containing 1
SynonymsERBB2IP|HEL-S-78|LAP2-
Cytomap

5q12.3

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionerbindensin-180-like proteinepididymis secretory protein Li 78protein LAP2peptidylprolyl isomerase domain and WD repeat-containing protein 1spliceosome-associated cyclophilin
Modification date2018052320180523
UniProtAcc

Q96BP3

Ensembl transtripts involved in fusion geneENST00000284037, ENST00000380943, 
ENST00000416865, ENST00000380935, 
ENST00000380939, ENST00000380936, 
ENST00000380938, ENST00000511297, 
ENST00000506030, ENST00000508515, 
ENST00000503913, 		ENST00000261308, 
ENST00000535264, ENST00000538977, 
Fusion gene scores* DoF score7 X 4 X 4=1123 X 2 X 3=18
# samples 73
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ERBB2IP [Title/Abstract] AND PPWD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPWD1

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1FD-01AERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000284037ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000284037ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000284037ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380943ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380943ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380943ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000416865ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000416865ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000416865ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380935ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380935ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380935ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380939ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380939ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380939ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380936ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380936ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380936ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380938ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380938ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000380938ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000511297ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000511297ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000511297ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000506030ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000506030ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
5UTR-3CDSENST00000506030ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000508515ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000508515ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000508515ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000503913ENST00000261308ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000503913ENST00000535264ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+
intron-3CDSENST00000503913ENST00000538977ERBB2IPchr5

65222634

+PPWD1chr5

64872706

+

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FusionProtFeatures for ERBB2IP_PPWD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2IP

PPWD1

Q96BP3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638,ECO:0000269|PubMed:20676357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERBB2IP_PPWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERBB2IP_PPWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERBB2IPPKP4, SMAD1, SMAD2, SMAD3, SMAD4, SMAD7, ITGB4, DST, KCNA4, GRIN2C, GRIN2B, ERBB2, ERBB2IP, PICK1, LRRC1, PDZD2, HRAS, CTNND1, ARVCF, RPAP1, APC, MYC, ZFYVE9, CHUK, CFTR, ACTN1, ACTN2, ABCA1, ABR, AGTR2, ATP2B1, ATP2B2, ATP2B4, ACVR2A, ACVR2B, BANF1, BCR, CTSG, KCNA5, SCN4A, COPB1, MCC, CASK, CTNNB1, GUCY1A2, MPP1, FOXO3, LAMB1, MAP4, MEF2A, MAPK12, MPP2, MPP3, ABCC4, NR2E1, SLC6A12, LMO1, SLC5A5, SLC5A6, VIPR2, ARHGEF7, LMO2, STAT3, CUL3, AZU1, HOXC4, PPP1CC, PPP1CA, CTSK, PPP1R3A, BTRC, MED4, TMEM17, XPO1, CLTC, DBN1, LIMK1, XRCC3, GTSE1, MYO19, CBL, CDH1, ZNF764, ZNF785, ZNF517, TRMT2A, ZNF581, ZNF264, OBP2A, ZNF408, ZNF550, CERKL, ZNF563, ARHGAP19, TRIM41, ZNF414, RNF7, RBX1PPWD1EED, ADRBK1, ACOX1, DDX6, PTPRF, PTBP3, NTRK1, SEC13, ZNF232


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERBB2IP_PPWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERBB2IP_PPWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource