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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11887

FusionGeneSummary for ERAL1_DIDO1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERAL1_DIDO1
Fusion gene ID: 11887
HgeneTgene
Gene symbol

ERAL1

DIDO1

Gene ID

26284

11083

Gene nameEra like 12S mitochondrial rRNA chaperone 1death inducer-obliterator 1
SynonymsCEGA|ERA|ERA-W|ERAL1A|ERAL1B|H-ERA|HERA-A|HERA-B|PRLTS6BYE1|C20orf158|DATF-1|DATF1|DIDO2|DIDO3|DIO-1|DIO1|dJ885L7.8
Cytomap

17q11.2

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionGTPase Era, mitochondrialERA-like protein 1Era G-protein-like 1GTP-binding protein era homologGTPase, human homolog of E. coli essential cell cycle protein Eraconserved ERA-like GTPaseera (E. coli G-protein homolog)-like 1death-inducer obliterator 1death-associated transcription factor 1
Modification date2018052320180519
UniProtAcc

O75616

Q9BTC0

Ensembl transtripts involved in fusion geneENST00000254928, ENST00000578001, 
ENST00000266070, ENST00000395343, 
ENST00000395340, ENST00000395335, 
ENST00000370371, ENST00000370368, 
ENST00000354665, ENST00000370366, 
ENST00000266071, 
Fusion gene scores* DoF score3 X 4 X 2=245 X 5 X 2=50
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: ERAL1 [Title/Abstract] AND DIDO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A1-A0SJ-01AERAL1chr17

27182335

+DIDO1chr20

61513766

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000254928ENST00000266070ERAL1chr17

27182335

+DIDO1chr20

61513766

-
Frame-shiftENST00000254928ENST00000395343ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000395340ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000395335ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000370371ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000370368ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000354665ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000370366ERAL1chr17

27182335

+DIDO1chr20

61513766

-
5CDS-intronENST00000254928ENST00000266071ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-3CDSENST00000578001ENST00000266070ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-3CDSENST00000578001ENST00000395343ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000395340ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000395335ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000370371ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000370368ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000354665ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000370366ERAL1chr17

27182335

+DIDO1chr20

61513766

-
3UTR-intronENST00000578001ENST00000266071ERAL1chr17

27182335

+DIDO1chr20

61513766

-

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FusionProtFeatures for ERAL1_DIDO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERAL1

O75616

DIDO1

Q9BTC0

Probable GTPase that plays a role in the mitochondrialribosomal small subunit assembly. Specifically binds the 12Smitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide sectiondelineating the 3' terminal stem-loop region. May act as achaperone that protects the 12S mt-rRNA on the 28S mitoribosomalsubunit during ribosomal small subunit assembly.{ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745,ECO:0000269|PubMed:28449065}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERAL1_DIDO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERAL1_DIDO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERAL1ICT1, TCF3, CUL3, CAND1, ACAD9, ALOX15B, FAM50B, SLC25A46, ECT2, C1QBP, FUS, CEP44, CCDC8, HNRNPDL, MRPS2, ZC3H3, COL1A1, ATPAF1, COL1A2, MCAT, COL3A1, XRCC3, ANKFY1, FOXA3, FOXS1, CDC5L, CISD3, C2orf47, NDUFA4, COQ9, ADCK4, NFATC2, LRP1DIDO1DVL3, HNRNPK, WWP2, SRSF1, WWP1, SIRT7, APP, KRT7, U2AF1, RPL18A, GNL3, H2AFY2, H2AFY, PCDHA2, RRS1, SON, ARAF, KCNK4, SRPK2, HECW2, RPA3, RPA2, RPA1, WWOX, HIST3H3, EED, BMI1, KLHDC3, RBM15, KRAS, FBXW7, PCGF1, HCFC2, SFPQ, CAMK2D, CAPN13, JMJD6, ID2, TRIM25, UHRF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERAL1_DIDO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERAL1_DIDO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource