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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11853

FusionGeneSummary for EPS15L1_MOB2

check button Fusion gene summary
Fusion gene informationFusion gene name: EPS15L1_MOB2
Fusion gene ID: 11853
HgeneTgene
Gene symbol

EPS15L1

MOB2

Gene ID

58513

81532

Gene nameepidermal growth factor receptor pathway substrate 15 like 1MOB kinase activator 2
SynonymsEPS15RHCCA2
Cytomap

19p13.11

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related proteinMOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2
Modification date2018052220180519
UniProtAcc

Q9UBC2

Q70IA6

Ensembl transtripts involved in fusion geneENST00000455140, ENST00000248070, 
ENST00000535753, ENST00000594975, 
ENST00000602009, ENST00000597937, 
ENST00000329957, ENST00000526462, 
Fusion gene scores* DoF score15 X 11 X 10=16507 X 10 X 2=140
# samples 1812
** MAII scorelog2(18/1650*10)=-3.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/140*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPS15L1 [Title/Abstract] AND MOB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI042611EPS15L1chr19

16485209

-MOB2chr11

1774551

+
ChiTaRS3.1BI042612EPS15L1chr19

16485209

-MOB2chr11

1774551

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000455140ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000455140ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000248070ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000248070ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000535753ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000535753ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000594975ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000594975ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000602009ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000602009ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000597937ENST00000329957EPS15L1chr19

16485209

-MOB2chr11

1774551

+
intron-intronENST00000597937ENST00000526462EPS15L1chr19

16485209

-MOB2chr11

1774551

+

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FusionProtFeatures for EPS15L1_MOB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPS15L1

Q9UBC2

MOB2

Q70IA6

Seems to be a constitutive component of clathrin-coatedpits that is required for receptor-mediated endocytosis. Involvedin endocytosis of integrin beta-1 (ITGB1) and transferrin receptor(TFR); internalization of ITGB1 as DAB2-dependent cargo but notTFR seems to require association with DAB2.{ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. Stimulates the autophosphorylation and kinase activityof STK38 and STK38L. {ECO:0000269|PubMed:15067004}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPS15L1_MOB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPS15L1_MOB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPS15L1_MOB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPS15L1_MOB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource