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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11839

FusionGeneSummary for EPN2_SLC5A10

check button Fusion gene summary
Fusion gene informationFusion gene name: EPN2_SLC5A10
Fusion gene ID: 11839
HgeneTgene
Gene symbol

EPN2

SLC5A10

Gene ID

22905

125206

Gene nameepsin 2solute carrier family 5 member 10
SynonymsEHB21SGLT-5|SGLT5
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionepsin-2EPS-15-interacting protein 2Eps15 binding proteinsodium/glucose cotransporter 5Na(+)/glucose cotransporter 5solute carrier family 5 (sodium/glucose cotransporter), member 10solute carrier family 5 (sodium/sugar cotransporter), member 10
Modification date2018052220180403
UniProtAcc

O95208

A0PJK1

Ensembl transtripts involved in fusion geneENST00000441293, ENST00000314728, 
ENST00000347697, ENST00000395618, 
ENST00000575595, ENST00000395620, 
ENST00000395626, ENST00000571254, 
ENST00000317977, ENST00000395642, 
ENST00000395647, ENST00000417251, 
ENST00000395643, ENST00000395645, 
Fusion gene scores* DoF score5 X 3 X 4=601 X 1 X 1=1
# samples 61
** MAII scorelog2(6/60*10)=0log2(1/1*10)=3.32192809488736
Context

PubMed: EPN2 [Title/Abstract] AND SLC5A10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A5A1-01AEPN2chr17

19140844

+SLC5A10chr17

18916723

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000441293ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000441293ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000441293ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000441293ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000441293ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000441293ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000314728ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000314728ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000314728ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000314728ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000314728ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000314728ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000347697ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000347697ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000347697ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000347697ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000347697ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000347697ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000395618ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000395618ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000395618ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000395618ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000395618ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000395618ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000575595ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000575595ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-3CDSENST00000575595ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000575595ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000575595ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
5UTR-intronENST00000575595ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395620ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395620ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395620ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395620ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395620ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395620ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395626ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395626ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000395626ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395626ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395626ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000395626ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000571254ENST00000317977EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000571254ENST00000395642EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-3CDSENST00000571254ENST00000395647EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000571254ENST00000417251EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000571254ENST00000395643EPN2chr17

19140844

+SLC5A10chr17

18916723

+
intron-intronENST00000571254ENST00000395645EPN2chr17

19140844

+SLC5A10chr17

18916723

+

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FusionProtFeatures for EPN2_SLC5A10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPN2

O95208

SLC5A10

A0PJK1

Plays a role in the formation of clathrin-coatedinvaginations and endocytosis. {ECO:0000269|PubMed:10567358}. High capacity transporter for mannose and fructose and,to a lesser extent, glucose, AMG, and galactose.{ECO:0000269|PubMed:22212718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPN2_SLC5A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPN2_SLC5A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EPN2CLTC, ITSN1, UBQLN2, UBC, APOE, RALBP1, EPN3, TMEM17, GTSE1, CDH1, RAB3IP, WBP2SLC5A10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPN2_SLC5A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPN2_SLC5A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource