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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11815

FusionGeneSummary for EPHA7_PIGH

check button Fusion gene summary
Fusion gene informationFusion gene name: EPHA7_PIGH
Fusion gene ID: 11815
HgeneTgene
Gene symbol

EPHA7

PIGH

Gene ID

2045

5283

Gene nameEPH receptor A7phosphatidylinositol glycan anchor biosynthesis class H
SynonymsEHK-3|EHK3|EK11|HEK11GPI-H
Cytomap

6q16.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionephrin type-A receptor 7EPH homology kinase 3EPH-like kinase 11Eph homology kinase-3receptor protein-tyrosine kinase HEK11tyrosine-protein kinase receptor EHK-3phosphatidylinositol N-acetylglucosaminyltransferase subunit Hphosphatidylinositol-glycan biosynthesis, class H protein
Modification date2018052320180529
UniProtAcc

Q15375

Q14442

Ensembl transtripts involved in fusion geneENST00000369303, ENST00000369297, 
ENST00000216452, ENST00000560722, 
ENST00000559581, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: EPHA7 [Title/Abstract] AND PIGH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPHA7

GO:0048013

ephrin receptor signaling pathway

17726105

HgeneEPHA7

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

17726105

HgeneEPHA7

GO:0070372

regulation of ERK1 and ERK2 cascade

17726105


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5744-01AEPHA7chr6

94066435

-PIGHchr14

68060669

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000369303ENST00000216452EPHA7chr6

94066435

-PIGHchr14

68060669

-
Frame-shitENST00000369303ENST00000560722EPHA7chr6

94066435

-PIGHchr14

68060669

-
5CDS-intronENST00000369303ENST00000559581EPHA7chr6

94066435

-PIGHchr14

68060669

-
intron-3CDSENST00000369297ENST00000216452EPHA7chr6

94066435

-PIGHchr14

68060669

-
intron-3CDSENST00000369297ENST00000560722EPHA7chr6

94066435

-PIGHchr14

68060669

-
intron-intronENST00000369297ENST00000559581EPHA7chr6

94066435

-PIGHchr14

68060669

-

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FusionProtFeatures for EPHA7_PIGH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPHA7

Q15375

PIGH

Q14442

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine tophosphatidylinositol, the first step of GPI biosynthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPHA7_PIGH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPHA7_PIGH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EPHA7EFNA2, EFNA3, EFNA5, MLLT4, MAP1LC3A, GNB1, ZNF267, HLA-DPA1, CACNG2, TMEM231, TMEM30A, PICK1, UBR2, HERC2, TMEM216, EPHA10, MBLAC2, EPHA3, TMPRSS11B, BCAM, TMEM30B, TMX1, NID2, SMOC1, MICA, RPL23, EPHA4, LRRIQ1, MRAP2, NPTX1, TUBA4A, HSPA5, BORA, MANSC1, AGAP1, EMC1, IL17RC, IL17RB, OAF, IARS2, RAET1E, WNT5A, PC, DUSP18, DUSP26, STYX, MTMR14PIGHPIGA, PIGQ, VKORC1, P2RX4, IL18RAP, PIGP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPHA7_PIGH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPHA7_PIGH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPHA7C0149925Small cell carcinoma of lung1CTD_human