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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11786

FusionGeneSummary for EPC2_RNF111

check button Fusion gene summary
Fusion gene informationFusion gene name: EPC2_RNF111
Fusion gene ID: 11786
HgeneTgene
Gene symbol

EPC2

RNF111

Gene ID

26122

54778

Gene nameenhancer of polycomb homolog 2ring finger protein 111
SynonymsEPC-LIKEARK|hRNF111
Cytomap

2q23.1

15q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionenhancer of polycomb homolog 2E3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadia
Modification date2018052320180523
UniProtAcc

Q52LR7

Q6ZNA4

Ensembl transtripts involved in fusion geneENST00000258484, ENST00000409654, 
ENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
Fusion gene scores* DoF score7 X 6 X 2=847 X 6 X 5=210
# samples 77
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPC2 [Title/Abstract] AND RNF111 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF329244EPC2chr2

149519492

+RNF111chr15

59359150

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000258484ENST00000348370EPC2chr2

149519492

+RNF111chr15

59359150

-
Frame-shiftENST00000258484ENST00000434298EPC2chr2

149519492

+RNF111chr15

59359150

-
Frame-shiftENST00000258484ENST00000559209EPC2chr2

149519492

+RNF111chr15

59359150

-
Frame-shiftENST00000258484ENST00000557998EPC2chr2

149519492

+RNF111chr15

59359150

-
Frame-shiftENST00000258484ENST00000561186EPC2chr2

149519492

+RNF111chr15

59359150

-
5CDS-intronENST00000258484ENST00000560080EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-3CDSENST00000409654ENST00000348370EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-3CDSENST00000409654ENST00000434298EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-3CDSENST00000409654ENST00000559209EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-3CDSENST00000409654ENST00000557998EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-3CDSENST00000409654ENST00000561186EPC2chr2

149519492

+RNF111chr15

59359150

-
intron-intronENST00000409654ENST00000560080EPC2chr2

149519492

+RNF111chr15

59359150

-

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FusionProtFeatures for EPC2_RNF111


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPC2

Q52LR7

RNF111

Q6ZNA4

May play a role in transcription or DNA repair.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPC2_RNF111


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPC2_RNF111


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPC2_RNF111


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPC2_RNF111


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource