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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11780

FusionGeneSummary for EPC1_ZEB1

check button Fusion gene summary
Fusion gene informationFusion gene name: EPC1_ZEB1
Fusion gene ID: 11780
HgeneTgene
Gene symbol

EPC1

ZEB1

Gene ID

80314

6935

Gene nameenhancer of polycomb homolog 1zinc finger E-box binding homeobox 1
SynonymsEpl1AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A
Cytomap

10p11.22

10p11.22

Type of geneprotein-codingprotein-coding
Descriptionenhancer of polycomb homolog 1zinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding prote
Modification date2018052320180527
UniProtAcc

Q9H2F5

P37275

Ensembl transtripts involved in fusion geneENST00000375110, ENST00000319778, 
ENST00000263062, ENST00000480402, 
ENST00000320985, ENST00000361642, 
ENST00000559858, ENST00000560721, 
ENST00000542815, ENST00000446923, 
Fusion gene scores* DoF score8 X 6 X 5=2406 X 6 X 2=72
# samples 86
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPC1 [Title/Abstract] AND ZEB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPC1

GO:0000122

negative regulation of transcription by RNA polymerase II

10976108

HgeneEPC1

GO:0043967

histone H4 acetylation

14966270

HgeneEPC1

GO:0043968

histone H2A acetylation

14966270

HgeneEPC1

GO:0045814

negative regulation of gene expression, epigenetic

10976108

HgeneEPC1

GO:0045892

negative regulation of transcription, DNA-templated

10976108

HgeneEPC1

GO:0045944

positive regulation of transcription by RNA polymerase II

10976108

TgeneZEB1

GO:0000122

negative regulation of transcription by RNA polymerase II

23765923|23814079

TgeneZEB1

GO:0045892

negative regulation of transcription, DNA-templated

20418909


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB111441EPC1chr10

32635691

-ZEB1chr10

31749965

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000375110ENST00000320985EPC1chr10

32635691

-ZEB1chr10

31749965

+
intron-3CDSENST00000375110ENST00000361642EPC1chr10

32635691

-ZEB1chr10

31749965

+
intron-3UTRENST00000375110ENST00000559858EPC1chr10

32635691

-ZEB1chr10

31749965

+
intron-3UTRENST00000375110ENST00000560721EPC1chr10

32635691

-ZEB1chr10

31749965

+
intron-intronENST00000375110ENST00000542815EPC1chr10

32635691

-ZEB1chr10

31749965

+
intron-intronENST00000375110ENST00000446923EPC1chr10

32635691

-ZEB1chr10

31749965

+
Frame-shitENST00000319778ENST00000320985EPC1chr10

32635691

-ZEB1chr10

31749965

+
Frame-shitENST00000319778ENST00000361642EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-3UTRENST00000319778ENST00000559858EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-3UTRENST00000319778ENST00000560721EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-intronENST00000319778ENST00000542815EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-intronENST00000319778ENST00000446923EPC1chr10

32635691

-ZEB1chr10

31749965

+
Frame-shitENST00000263062ENST00000320985EPC1chr10

32635691

-ZEB1chr10

31749965

+
Frame-shitENST00000263062ENST00000361642EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-3UTRENST00000263062ENST00000559858EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-3UTRENST00000263062ENST00000560721EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-intronENST00000263062ENST00000542815EPC1chr10

32635691

-ZEB1chr10

31749965

+
5CDS-intronENST00000263062ENST00000446923EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-3CDSENST00000480402ENST00000320985EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-3CDSENST00000480402ENST00000361642EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-3UTRENST00000480402ENST00000559858EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-3UTRENST00000480402ENST00000560721EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-intronENST00000480402ENST00000542815EPC1chr10

32635691

-ZEB1chr10

31749965

+
5UTR-intronENST00000480402ENST00000446923EPC1chr10

32635691

-ZEB1chr10

31749965

+

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FusionProtFeatures for EPC1_ZEB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPC1

Q9H2F5

ZEB1

P37275


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPC1_ZEB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPC1_ZEB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EPC1ING3, SRF, MRGBP, E2F6, EZH2, EED, MORF4L1, MORF4L2, MYC, DMAP1, KAT5, H2AFZ, TRIM27, HOPX, KRT15, RINT1, PLAC1, FOXR1, FOXR2, HIST1H2BA, YEATS4, MED23, TRRAP, FOXO6, EP400, BRD8, MBTD1, RUVBL1, RUVBL2, VPS72, ACTB, MEAF6, ACTL6A, MYCLZEB1DRAP1, KAT5, SMAD2, SMAD3, SMAD1, CTBP1, CTBP2, SERPINH1, SMARCA4, SMAD6, SMAD7, SIRT1, SOX2, UBR4, GTF2A1, CDK6, EP300, CREBBP, USP7, CHEK1, ATM, DCAF15, EWSR1, SYNCRIP, MPHOSPH8, ZMIZ1, USP10, USP13, USP26, USP29, USP42, USP51, PAN2, USP53, USP54, UCHL3, VCPIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPC1_ZEB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPC1_ZEB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZEB1C2750448CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 63CTD_human;UNIPROT
TgeneZEB1C1458155Mammary Neoplasms2CTD_human
TgeneZEB1C0007621Neoplastic Cell Transformation1CTD_human
TgeneZEB1C0014170Endometrial Neoplasms1CTD_human
TgeneZEB1C0027626Neoplasm Invasiveness1CTD_human
TgeneZEB1C0029172Oral Submucous Fibrosis1CTD_human
TgeneZEB1C0036920Sezary Syndrome1CTD_human
TgeneZEB1C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneZEB1C0151744Myocardial Ischemia1CTD_human
TgeneZEB1C0919267ovarian neoplasm1CTD_human