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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11742

FusionGeneSummary for EPB41L3_FYB

check button Fusion gene summary
Fusion gene informationFusion gene name: EPB41L3_FYB
Fusion gene ID: 11742
HgeneTgene
Gene symbol

EPB41L3

FYB

Gene ID

23136

Gene nameerythrocyte membrane protein band 4.1 like 3
Synonyms4.1B|DAL-1|DAL1
Cytomap

18p11.31

Type of geneprotein-coding
Descriptionband 4.1-like protein 3differentially expressed in adenocarcinoma of the lung protein 1
Modification date20180523
UniProtAcc

Q9Y2J2

Ensembl transtripts involved in fusion geneENST00000341928, ENST00000544123, 
ENST00000540638, ENST00000342933, 
ENST00000400111, ENST00000542652, 
ENST00000427684, ENST00000542146, 
ENST00000351578, ENST00000515010, 
ENST00000505428, ENST00000512982, 
ENST00000540520, ENST00000503065, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 5=245
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPB41L3 [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF931907EPB41L3chr18

5393395

-FYBchr5

39127859

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341928ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000341928ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000341928ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000341928ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000341928ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000341928ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000544123ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000544123ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000544123ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000544123ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000544123ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000544123ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000540638ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000540638ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000540638ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000540638ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000540638ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000540638ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000342933ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000342933ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000342933ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000342933ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000342933ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000342933ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000400111ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000400111ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000400111ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000400111ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000400111ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000400111ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542652ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542652ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542652ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542652ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542652ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000542652ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000427684ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000427684ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000427684ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000427684ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000427684ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000427684ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542146ENST00000351578EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542146ENST00000515010EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542146ENST00000505428EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542146ENST00000512982EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-3CDSENST00000542146ENST00000540520EPB41L3chr18

5393395

-FYBchr5

39127859

+
intron-intronENST00000542146ENST00000503065EPB41L3chr18

5393395

-FYBchr5

39127859

+

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FusionProtFeatures for EPB41L3_FYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41L3

Q9Y2J2

FYB

Tumor suppressor that inhibits cell proliferation andpromotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.{ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618,ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPB41L3_FYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPB41L3_FYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPB41L3_FYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPB41L3_FYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPB41L3C1458155Mammary Neoplasms1CTD_human