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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11737

FusionGeneSummary for EPB41L2_MAP4K1

check button Fusion gene summary
Fusion gene informationFusion gene name: EPB41L2_MAP4K1
Fusion gene ID: 11737
HgeneTgene
Gene symbol

EPB41L2

MAP4K1

Gene ID

2037

11184

Gene nameerythrocyte membrane protein band 4.1 like 2mitogen-activated protein kinase kinase kinase kinase 1
Synonyms4.1-G|4.1GHPK1
Cytomap

6q23.1-q23.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionband 4.1-like protein 2erythrocyte membrane protein band 4.1 like-protein 2generally expressed protein 4.1mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1
Modification date2018052320180527
UniProtAcc

O43491

Q92918

Ensembl transtripts involved in fusion geneENST00000528282, ENST00000530481, 
ENST00000445890, ENST00000337057, 
ENST00000530757, ENST00000392427, 
ENST00000368128, ENST00000527411, 
ENST00000524581, ENST00000525271, 
ENST00000525193, ENST00000527659, 
ENST00000529208, ENST00000531410, 
ENST00000530148, 
ENST00000591517, 
ENST00000586296, ENST00000589130, 
ENST00000396857, ENST00000423454, 
ENST00000589002, 
Fusion gene scores* DoF score8 X 5 X 5=2004 X 3 X 4=48
# samples 94
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPB41L2 [Title/Abstract] AND MAP4K1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP4K1

GO:0006468

protein phosphorylation

8824585

TgeneMAP4K1

GO:0007257

activation of JUN kinase activity

8824585

TgeneMAP4K1

GO:0018105

peptidyl-serine phosphorylation

11053428|24362026

TgeneMAP4K1

GO:0046777

protein autophosphorylation

8824585|24362026

TgeneMAP4K1

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

8824585


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-AY-6196-01AEPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000528282ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000528282ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000528282ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000528282ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000528282ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000528282ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530481ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530481ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530481ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530481ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530481ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530481ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000445890ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000445890ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000445890ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000445890ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000445890ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000445890ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000337057ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000337057ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000337057ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000337057ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-intronENST00000337057ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-intronENST00000337057ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530757ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530757ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530757ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530757ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530757ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530757ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000392427ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000392427ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000392427ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-3CDSENST00000392427ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-intronENST00000392427ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
5UTR-intronENST00000392427ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000368128ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000368128ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000368128ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000368128ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000368128ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000368128ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527411ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527411ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527411ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527411ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000527411ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000527411ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000524581ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000524581ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000524581ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000524581ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000524581ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000524581ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525271ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525271ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525271ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525271ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000525271ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000525271ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525193ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525193ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525193ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000525193ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000525193ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000525193ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527659ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527659ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527659ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000527659ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000527659ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000527659ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000529208ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000529208ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000529208ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000529208ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000529208ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000529208ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000531410ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000531410ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000531410ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000531410ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000531410ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000531410ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530148ENST00000591517EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530148ENST00000586296EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530148ENST00000589130EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-3CDSENST00000530148ENST00000396857EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530148ENST00000423454EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-
intron-intronENST00000530148ENST00000589002EPB41L2chr6

131384295

-MAP4K1chr19

39078457

-

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FusionProtFeatures for EPB41L2_MAP4K1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41L2

O43491

MAP4K1

Q92918

Required for dynein-dynactin complex and NUMA1recruitment at the mitotic cell cortex during anaphase(PubMed:23870127). {ECO:0000269|PubMed:23870127}. Serine/threonine-protein kinase, which may play a rolein the response to environmental stress. Appears to act upstreamof the JUN N-terminal pathway. May play a role in hematopoieticlineage decisions and growth regulation. Able toautophosphorylate. {ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:8824585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EPB41L2_MAP4K1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPB41L2_MAP4K1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EPB41L2FKBP2, GRIA1, YWHAQ, NUMA1, YWHAZ, YWHAG, SIRT7, ATXN1L, APP, CALD1, COPS4, CSNK2A1, DCAF8, WDR77, CCDC8, ABCE1, DDAH2, EPB41L3, WWC1, LIN7A, HSPB1, NUP35, NSMAF, KLC4, PAX6, EGFR, EPB41L1, MLLT1, MLLT3, RNPS1, PNN, ACIN1, GPATCH8, CWC22, WDR59, SETD1A, ZRANB2, CLNS1A, SRRM2, CLK2, NKAP, SRP68, POTEI, AP3B1, PPIG, CYP2S1, GJB7, MLF1MAP4K1GRB2, CRK, CRKL, BLNK, DBNL, GRAP2, NCK1, EGFR, MAP3K7, MAP3K11, HCLS1, LAT, PPP4C, COPS5, LRRK1, SPRY1, HSP90AA1, TMEM101, SKP1, RBX1, CUL7, FBXW8, FBXW7, MAP4K1, HIST1H2AB, HSD17B10, PDHA1, SDHA, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPB41L2_MAP4K1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPB41L2_MAP4K1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPB41L2C0023893Liver Cirrhosis, Experimental1CTD_human