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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11664

FusionGeneSummary for ENTPD5_TCTN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD5_TCTN3
Fusion gene ID: 11664
HgeneTgene
Gene symbol

ENTPD5

TCTN3

Gene ID

957

26123

Gene nameectonucleoside triphosphate diphosphohydrolase 5tectonic family member 3
SynonymsCD39L4|NTPDase-5|PCPHC10orf61|JBTS18|OFD4|TECT3
Cytomap

14q24.3

10q24.1

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase Etectonic-3
Modification date2018051920180519
UniProtAcc

O75356

Q6NUS6

Ensembl transtripts involved in fusion geneENST00000557325, ENST00000334696, 
ENST00000556242, ENST00000554664, 
ENST00000371217, ENST00000265993, 
ENST00000430368, ENST00000371209, 
Fusion gene scores* DoF score7 X 4 X 6=1683 X 3 X 2=18
# samples 73
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ENTPD5 [Title/Abstract] AND TCTN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCTN3

GO:0043065

positive regulation of apoptotic process

17464193


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW578884ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000557325ENST00000371217ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000557325ENST00000265993ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000557325ENST00000430368ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-intronENST00000557325ENST00000371209ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000334696ENST00000371217ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000334696ENST00000265993ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000334696ENST00000430368ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-intronENST00000334696ENST00000371209ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000556242ENST00000371217ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000556242ENST00000265993ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000556242ENST00000430368ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-intronENST00000556242ENST00000371209ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000554664ENST00000371217ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000554664ENST00000265993ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-3CDSENST00000554664ENST00000430368ENTPD5chr14

74433567

-TCTN3chr10

97423888

+
intron-intronENST00000554664ENST00000371209ENTPD5chr14

74433567

-TCTN3chr10

97423888

+

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FusionProtFeatures for ENTPD5_TCTN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENTPD5

O75356

TCTN3

Q6NUS6

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotesprotein N-glycosylation and folding in the endoplasmic reticulum,as well as elevated ATP consumption in the cytosol via an ATPhydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATPhydrolysis cycle that converts ATP to AMP and results in acompensatory increase in aerobic glycolysis. The nucleotidehydrolyzing preference is GDP > IDP > UDP, but not any othernucleoside di-, mono- or triphosphates, nor thiaminepyrophosphate. Plays a key role in the AKT1-PTEN signaling pathwayby promoting glycolysis in proliferating cells in response tophosphoinositide 3-kinase (PI3K) signaling.{ECO:0000269|PubMed:10400613}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENTPD5_TCTN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENTPD5_TCTN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENTPD5_TCTN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENTPD5_TCTN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCTN3C3553758JOUBERT SYNDROME 181UNIPROT