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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11662

FusionGeneSummary for ENTPD5_NUBPL

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD5_NUBPL
Fusion gene ID: 11662
HgeneTgene
Gene symbol

ENTPD5

NUBPL

Gene ID

957

80224

Gene nameectonucleoside triphosphate diphosphohydrolase 5nucleotide binding protein like
SynonymsCD39L4|NTPDase-5|PCPHC14orf127|IND1|huInd1
Cytomap

14q24.3

14q12

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase Eiron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase
Modification date2018051920180523
UniProtAcc

O75356

Q8TB37

Ensembl transtripts involved in fusion geneENST00000557325, ENST00000334696, 
ENST00000556242, ENST00000554664, 
ENST00000281081, ENST00000536705, 
ENST00000418681, 
Fusion gene scores* DoF score7 X 4 X 6=1688 X 5 X 6=240
# samples 78
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENTPD5 [Title/Abstract] AND NUBPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A3IK-01AENTPD5chr14

74436713

-NUBPLchr14

32295835

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000557325ENST00000281081ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
Frame-shiftENST00000557325ENST00000536705ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
5CDS-3UTRENST00000557325ENST00000418681ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
Frame-shiftENST00000334696ENST00000281081ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
Frame-shiftENST00000334696ENST00000536705ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
5CDS-3UTRENST00000334696ENST00000418681ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3CDSENST00000556242ENST00000281081ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3CDSENST00000556242ENST00000536705ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3UTRENST00000556242ENST00000418681ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3CDSENST00000554664ENST00000281081ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3CDSENST00000554664ENST00000536705ENTPD5chr14

74436713

-NUBPLchr14

32295835

+
intron-3UTRENST00000554664ENST00000418681ENTPD5chr14

74436713

-NUBPLchr14

32295835

+

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FusionProtFeatures for ENTPD5_NUBPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENTPD5

O75356

NUBPL

Q8TB37

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotesprotein N-glycosylation and folding in the endoplasmic reticulum,as well as elevated ATP consumption in the cytosol via an ATPhydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATPhydrolysis cycle that converts ATP to AMP and results in acompensatory increase in aerobic glycolysis. The nucleotidehydrolyzing preference is GDP > IDP > UDP, but not any othernucleoside di-, mono- or triphosphates, nor thiaminepyrophosphate. Plays a key role in the AKT1-PTEN signaling pathwayby promoting glycolysis in proliferating cells in response tophosphoinositide 3-kinase (PI3K) signaling.{ECO:0000269|PubMed:10400613}. Required for the assembly of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I). May deliver ofone or more Fe-S clusters to complex I subunits.{ECO:0000269|PubMed:19752196}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENTPD5_NUBPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENTPD5_NUBPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ENTPD5MXI1, IDS, FBXO6, BCHE, LYZL2NUBPLMTUS2, RNF2, DNAJB11, UFD1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENTPD5_NUBPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENTPD5_NUBPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUBPLC0751651Mitochondrial Diseases1CTD_human
TgeneNUBPLC1838979MITOCHONDRIAL COMPLEX I DEFICIENCY1CTD_human;UNIPROT