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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11653

FusionGeneSummary for ENTPD1_IKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD1_IKZF1
Fusion gene ID: 11653
HgeneTgene
Gene symbol

ENTPD1

IKZF1

Gene ID

953

10320

Gene nameectonucleoside triphosphate diphosphohydrolase 1IKAROS family zinc finger 1
SynonymsATPDase|CD39|NTPDase-1|SPG64CVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1
Cytomap

10q24.1

7p12.2

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 1CD39 antigenecto-ATP diphosphohydrolase 1ecto-ATPDase 1ecto-ATPase 1ecto-apyraselymphoid cell activation antigenDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)
Modification date2018051920180527
UniProtAcc

P49961

Q13422

Ensembl transtripts involved in fusion geneENST00000453258, ENST00000543964, 
ENST00000371207, ENST00000371203, 
ENST00000539125, ENST00000371205, 
ENST00000490659, 
ENST00000440768, 
ENST00000359197, ENST00000343574, 
ENST00000331340, ENST00000349824, 
ENST00000357364, ENST00000346667, 
ENST00000438033, ENST00000439701, 
ENST00000413698, ENST00000492782, 
Fusion gene scores* DoF score5 X 6 X 2=606 X 6 X 3=108
# samples 86
** MAII scorelog2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENTPD1 [Title/Abstract] AND IKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF374130ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000453258ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000453258ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000453258ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000453258ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000453258ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000453258ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000453258ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000453258ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000453258ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000453258ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000453258ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000543964ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000543964ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000543964ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000543964ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000543964ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000543964ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371207ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371207ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371207ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371207ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371207ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371207ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371203ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371203ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371203ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371203ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371203ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371203ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000539125ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000539125ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000539125ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000539125ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000539125ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000539125ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371205ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371205ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371205ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371205ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000371205ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000371205ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000440768ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000359197ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000490659ENST00000343574ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000490659ENST00000331340ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000490659ENST00000349824ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000490659ENST00000357364ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-3UTRENST00000490659ENST00000346667ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000438033ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000439701ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000413698ENTPD1chr10

97553089

+IKZF1chr7

50470625

+
intron-intronENST00000490659ENST00000492782ENTPD1chr10

97553089

+IKZF1chr7

50470625

+

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FusionProtFeatures for ENTPD1_IKZF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENTPD1

P49961

IKZF1

Q13422

Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENTPD1_IKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENTPD1_IKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENTPD1_IKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENTPD1_IKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENTPD1C3714756Intellectual Disability1CTD_human;HPO
HgeneENTPD1C3810289SPASTIC PARAPLEGIA 64, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT
TgeneIKZF1C0009324Ulcerative Colitis1CTD_human
TgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIKZF1C0024299Lymphoma1CTD_human
TgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT