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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11646

FusionGeneSummary for ENSA_NUTF2

check button Fusion gene summary
Fusion gene informationFusion gene name: ENSA_NUTF2
Fusion gene ID: 11646
HgeneTgene
Gene symbol

ENSA

NUTF2

Gene ID

2029

10204

Gene nameendosulfine alphanuclear transport factor 2
SynonymsARPP-19eNTF-2|NTF2|PP15
Cytomap

1q21.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-endosulfineendosulfine-alpha variant 1endosulfine-alpha variant 2endosulfine-alpha variant 3endosulfine-alpha variant 4endosulfine-alpha variant 5endosulfine-alpha variant 6nuclear transport factor 2placental protein 15
Modification date2018052320180523
UniProtAcc

O43768

P61970

Ensembl transtripts involved in fusion geneENST00000369016, ENST00000369014, 
ENST00000369009, ENST00000339643, 
ENST00000271690, ENST00000356527, 
ENST00000503345, ENST00000503241, 
ENST00000362052, ENST00000361532, 
ENST00000361631, ENST00000513281, 
ENST00000354702, 
ENST00000219169, 
ENST00000569436, ENST00000568396, 
Fusion gene scores* DoF score7 X 5 X 4=1407 X 4 X 5=140
# samples 77
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENSA [Title/Abstract] AND NUTF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENSA

GO:0050796

regulation of insulin secretion

9653196

TgeneNUTF2

GO:0006606

protein import into nucleus

7744965|10679025

TgeneNUTF2

GO:0006611

protein export from nucleus

16449645


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF215130ENSAchr1

150598245

-NUTF2chr16

67905115

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000369016ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369016ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369016ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369014ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369014ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369014ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369009ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369009ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000369009ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000339643ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000339643ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000339643ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000271690ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000271690ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000271690ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000356527ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000356527ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000356527ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503345ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503345ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503345ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503241ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503241ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000503241ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000362052ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000362052ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000362052ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361532ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361532ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361532ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361631ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361631ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000361631ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000513281ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000513281ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000513281ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000354702ENST00000219169ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000354702ENST00000569436ENSAchr1

150598245

-NUTF2chr16

67905115

+
intron-3UTRENST00000354702ENST00000568396ENSAchr1

150598245

-NUTF2chr16

67905115

+

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FusionProtFeatures for ENSA_NUTF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENSA

O43768

NUTF2

P61970

Mediates the import of GDP-bound RAN from the cytoplasminto the nucleus which is essential for the function of RAN incargo receptor-mediated nucleocytoplasmic transport. Thereby,plays indirectly a more general role in cargo receptor-mediatednucleocytoplasmic transport. Interacts with GDP-bound RAN in thecytosol, recruits it to the nuclear pore complex via itsinteraction with nucleoporins and promotes its nuclear import.{ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENSA_NUTF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENSA_NUTF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENSA_NUTF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENSA_NUTF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENSAC0151744Myocardial Ischemia1CTD_human
TgeneNUTF2C0019693HIV Infections1CTD_human