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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1162

FusionGeneSummary for AGRN_BAD

check button Fusion gene summary
Fusion gene informationFusion gene name: AGRN_BAD
Fusion gene ID: 1162
HgeneTgene
Gene symbol

AGRN

BAD

Gene ID

375790

572

Gene nameagrinBCL2 associated agonist of cell death
SynonymsAGRIN|CMS8|CMSPPDBBC2|BCL2L8
Cytomap

1p36.33

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionagrinagrin proteoglycanbcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of
Modification date2018052220180523
UniProtAcc

O00468

Q92934

Ensembl transtripts involved in fusion geneENST00000379370, ENST00000477585, 
ENST00000394532, ENST00000309032, 
ENST00000544785, ENST00000394531, 
Fusion gene scores* DoF score10 X 7 X 9=6306 X 5 X 6=180
# samples 119
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGRN [Title/Abstract] AND BAD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGRN

GO:0043113

receptor clustering

15340048

TgeneBAD

GO:0006915

apoptotic process

19667065

TgeneBAD

GO:0043065

positive regulation of apoptotic process

9388232

TgeneBAD

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937

TgeneBAD

GO:0045862

positive regulation of proteolysis

18387192

TgeneBAD

GO:0046931

pore complex assembly

19667065|21081150

TgeneBAD

GO:0071316

cellular response to nicotine

18676776

TgeneBAD

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-UC-A7PD-01AAGRNchr1

957842

+BADchr11

64039275

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379370ENST00000394532AGRNchr1

957842

+BADchr11

64039275

-
In-frameENST00000379370ENST00000309032AGRNchr1

957842

+BADchr11

64039275

-
5CDS-intronENST00000379370ENST00000544785AGRNchr1

957842

+BADchr11

64039275

-
5CDS-intronENST00000379370ENST00000394531AGRNchr1

957842

+BADchr11

64039275

-
intron-3CDSENST00000477585ENST00000394532AGRNchr1

957842

+BADchr11

64039275

-
intron-3CDSENST00000477585ENST00000309032AGRNchr1

957842

+BADchr11

64039275

-
intron-intronENST00000477585ENST00000544785AGRNchr1

957842

+BADchr11

64039275

-
intron-intronENST00000477585ENST00000394531AGRNchr1

957842

+BADchr11

64039275

-

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FusionProtFeatures for AGRN_BAD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGRN

O00468

BAD

Q92934

Isoform 1: heparan sulfate basal lamina glycoproteinthat plays a central role in the formation and the maintenance ofthe neuromuscular junction (NMJ) and directs key events inpostsynaptic differentiation. Component of the AGRN-LRP4 receptorcomplex that induces the phosphorylation and activation of MUSK.The activation of MUSK in myotubes induces the formation of NMJ byregulating different processes including the transcription ofspecific genes and the clustering of AChR in the postsynapticmembrane. Calcium ions are required for maximal AChR clustering.AGRN function in neurons is highly regulated by alternativesplicing, glycan binding and proteolytic processing. Modulatescalcium ion homeostasis in neurons, specifically by inducing anincrease in cytoplasmic calcium ions. Functions differentially inthe central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNSsynapses. This secreted isoform forms a bridge, after release frommotor neurons, to basal lamina through binding laminin via the NtAdomain. Isoform 2: transmembrane form that is the predominateform in neurons of the brain, induces dendritic filopodia andsynapse formation in mature hippocampal neurons in large part dueto the attached glycosaminoglycan chains and the action of Rho-family GTPases. Isoform 1, isoform 4 and isoform 5: neuron-specific (z+)isoforms that contain C-terminal insertions of 8-19 AA are potentactivators of AChR clustering. Isoform 5, agrin (z+8), containingthe 8-AA insert, forms a receptor complex in myotubules containingthe neuronal AGRN, the muscle-specific kinase MUSK and LRP4, amember of the LDL receptor family. The splicing factors, NOVA1 andNOVA2, regulate AGRN splicing and production of the 'z' isoforms. Isoform 3 and isoform 6: lack any 'z' insert, aremuscle-specific and may be involved in endothelial celldifferentiation. Agrin N-terminal 110 kDa subunit: is involved inregulation of neurite outgrowth probably due to the presence ofthe glycosaminoglcan (GAG) side chains of heparan and chondroitinsulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Alsoinvolved in modulation of growth factor signaling (By similarity).{ECO:0000250, ECO:0000269|PubMed:19631309,ECO:0000269|PubMed:21969364}. Agrin C-terminal 22 kDa fragment: this released fragmentis important for agrin signaling and to exert a maximal dendriticfilopodia-inducing effect. All 'z' splice variants (z+) of thisfragment also show an increase in the number of filopodia. Promotes cell death. Successfully competes for thebinding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the levelof heterodimerization of these proteins with BAX. Can reverse thedeath repressor activity of Bcl-X(L), but not that of Bcl-2 (Bysimilarity). Appears to act as a link between growth factorreceptor signaling and the apoptotic pathways. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+23630_1571542046DomainNtA
TgeneBADchr1:957842chr11:64039275ENST00000309032-14110_12462169MotifNote=BH3
TgeneBADchr1:957842chr11:64039275ENST00000394532-03110_12462169MotifNote=BH3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361940_20081542046Calcium bindingOntology_term=ECO:0000250
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361058_10971542046Compositional biasNote=Gly/Ser-rich
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361254_13241542046Compositional biasNote=Ser/Thr-rich
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236671_6771542046Compositional biasNote=Gly/Ser-rich
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236974_10991542046Compositional biasNote=Ser/Thr-rich
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361130_12521542046DomainSEA
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361329_13671542046DomainEGF-like 1
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361372_15481542046DomainLaminin G-like 1
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361549_15861542046DomainEGF-like 2
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361588_16251542046DomainEGF-like 3
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361635_18221542046DomainLaminin G-like 2
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361818_18571542046DomainEGF-like 4
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+2361868_20641542046DomainLaminin G-like 3
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236191_2441542046DomainKazal-like 1
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236264_3191542046DomainKazal-like 2
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236337_3911542046DomainKazal-like 3
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236408_4631542046DomainKazal-like 4
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236484_5361542046DomainKazal-like 5
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236540_6011542046DomainKazal-like 6
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236607_6661542046DomainKazal-like 7
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236699_7521542046DomainKazal-like 8
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236793_8461542046DomainLaminin EGF-like 1
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236847_8931542046DomainLaminin EGF-like 2
HgeneAGRNchr1:957842chr11:64039275ENST00000379370+236917_9711542046DomainKazal-like 9


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FusionGeneSequence for AGRN_BAD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000394532_chr11_64039275_-_261aa
MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGN
KVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEGAGAVEIRSRHSSYPAGTEDDEGMGE

>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000309032_chr11_64039275_-_261aa
MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGN
KVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEGAGAVEIRSRHSSYPAGTEDDEGMGE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000394532_chr11_64039275_-_783nt
ATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGCTGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACA
TGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTG
CAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAAC
AAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA
CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAG
TTCTGTGTGGAAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACGGAGGACGACGAAGGGATGGGGGAG
GAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCGCCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGT
GACGAGTTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAGCTCCAGCTGGACG

>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000309032_chr11_64039275_-_783nt
ATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGCTGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACA
TGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTG
CAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAAC
AAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA
CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAG
TTCTGTGTGGAAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACGGAGGACGACGAAGGGATGGGGGAG
GAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCGCCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGT
GACGAGTTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAGCTCCAGCTGGACG


* Fusion transcript sequences (Full-length transcript).
>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000394532_chr11_64039275_-_1212nt
CCCGTCCCCGGCGCGGCCCGCGCGCTCCTCCGCCGCCTCTCGCCTGCGCCATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGC
TGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGA
ACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACT
TGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTG
ACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCACCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGC
TCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGGCGCTGGGGCTGTGGAGATCCGGAGTC
GCCACAGCTCCTACCCCGCGGGGACGGAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCGCCCC
CCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAGTTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCC
CGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGCAGGG
GAAGCTCCGCCCCCTCCCAGTGACCTTCGCTCCACATCCCGAAACTCCACCCGTTCCCACTGCCCTGGGCAGCCATCTTGAATATGGGCG
GAAGTACTTCCCTCAGGCCTATGCAAAAAGAGGATCCGTGCTGTCTCCTTTGGAGGGAGGGCTGACCCAGATTCCCTTCCGGTGCGTGTG
AAGCCACGGAAGGCTTGGTCCCATCGGAAGTTTTGGGTTTTCCGCCCACAGCCGCCGGAAGTGGCTCCGTGGCCCCGCCCTCAGGCTCCG
GGCTTTCCCCCAGGCGCCTGCGCTAAGTCGCGAGCCAGGTTTAACCGTTGCGTCACCGGGACCCGAGCCCCCGCGATGCCCTGGGGGCCG

>In-frame_AGRN_ENST00000379370_chr1_957842_+_BAD_ENST00000309032_chr11_64039275_-_1208nt
CCCGTCCCCGGCGCGGCCCGCGCGCTCCTCCGCCGCCTCTCGCCTGCGCCATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGC
TGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGA
ACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACT
TGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTG
ACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCACCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGC
TCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGGCGCTGGGGCTGTGGAGATCCGGAGTC
GCCACAGCTCCTACCCCGCGGGGACGGAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCGCCCC
CCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAGTTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCC
CGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGCAGGG
GAAGCTCCGCCCCCTCCCAGTGACCTTCGCTCCACATCCCGAAACTCCACCCGTTCCCACTGCCCTGGGCAGCCATCTTGAATATGGGCG
GAAGTACTTCCCTCAGGCCTATGCAAAAAGAGGATCCGTGCTGTCTCCTTTGGAGGGAGGGCTGACCCAGATTCCCTTCCGGTGCGTGTG
AAGCCACGGAAGGCTTGGTCCCATCGGAAGTTTTGGGTTTTCCGCCCACAGCCGCCGGAAGTGGCTCCGTGGCCCCGCCCTCAGGCTCCG
GGCTTTCCCCCAGGCGCCTGCGCTAAGTCGCGAGCCAGGTTTAACCGTTGCGTCACCGGGACCCGAGCCCCCGCGATGCCCTGGGGGCCG


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FusionGenePPI for AGRN_BAD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGRNDAG1, ATXN7, CACNA1A, ATN1, GFI1B, PDIA3, TUBG1, MOV10, NXF1, ZFP41, SKI, CAMKV, CRP, OS9, OLFM3, UBCBADBCL2A1, MCL1, SFN, EWSR1, BCL2L2, BCL2L1, BCL2, YWHAQ, PRKCI, PIM2, YWHAE, YWHAB, YWHAH, S100A10, AKT1, PRKACA, RPS6KA1, RPS6KA5, YWHAZ, YWHAG, SUMO2, PPP1CA, BAX, SNCA, VCP, RAF1, PAK1, BRAF, ARAF, CREB3L3, CDKN1A, PRDX2, KEAP1, STEAP3, GIMAP5, PRKD1, PRKCE, NDUFA12, LIMK1, SORT1, SYNCRIP, APTX, CBY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGRN_BAD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGRN_BAD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGRNC3808739MYASTHENIC SYNDROME, CONGENITAL, 83UNIPROT
HgeneAGRNC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneBADC0033578Prostatic Neoplasms2CTD_human
TgeneBADC0007787Transient Ischemic Attack1CTD_human
TgeneBADC0023418leukemia1CTD_human