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Fusion gene ID: 11607 |
FusionGeneSummary for ENG_NOL9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ENG_NOL9 | Fusion gene ID: 11607 | Hgene | Tgene | Gene symbol | ENG | NOL9 | Gene ID | 2022 | 79707 |
| Gene name | endoglin | nucleolar protein 9 | |
| Synonyms | END|HHT1|ORW1 | Grc3|NET6 | |
| Cytomap | 9q34.11 | 1p36.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endoglinCD105 antigen | polynucleotide 5'-hydroxyl-kinase NOL9polynucleotide 5'-kinase | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P17813 | Q5SY16 | |
| Ensembl transtripts involved in fusion gene | ENST00000373203, ENST00000344849, ENST00000480266, | ENST00000377705, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ENG [Title/Abstract] AND NOL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ENG | GO:0001934 | positive regulation of protein phosphorylation | 12015308 |
| Hgene | ENG | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 12015308 |
| Hgene | ENG | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 15702480 |
| Hgene | ENG | GO:0030336 | negative regulation of cell migration | 19736306 |
| Hgene | ENG | GO:0030513 | positive regulation of BMP signaling pathway | 17068149 |
| Hgene | ENG | GO:0031953 | negative regulation of protein autophosphorylation | 12015308 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A8PE-01A | ENG | chr9 | 130579428 | - | NOL9 | chr1 | 6604982 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373203 | ENST00000377705 | ENG | chr9 | 130579428 | - | NOL9 | chr1 | 6604982 | - |
| In-frame | ENST00000344849 | ENST00000377705 | ENG | chr9 | 130579428 | - | NOL9 | chr1 | 6604982 | - |
| Frame-shift | ENST00000480266 | ENST00000377705 | ENG | chr9 | 130579428 | - | NOL9 | chr1 | 6604982 | - |
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FusionProtFeatures for ENG_NOL9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ENG | NOL9 |
| Vascular endothelium glycoprotein that plays animportant role in the regulation of angiogenesis (PubMed:21737454,PubMed:23300529). Required for normal structure and integrity ofadult vasculature (PubMed:7894484). Regulates the migration ofvascular endothelial cells (PubMed:17540773). Required for normalextraembryonic angiogenesis and for embryonic heart development(By similarity). May regulate endothelial cell shape changes inresponse to blood flow, which drive vascular remodeling andestablishment of normal vascular morphology during angiogenesis(By similarity). May play a critical role in the binding ofendothelial cells to integrins and/or other RGD receptors(PubMed:1692830). Acts as TGF-beta coreceptor and is involved inthe TGF-beta/BMP signaling cascade that ultimately leads to theactivation of SMAD transcription factors (PubMed:8370410,PubMed:21737454, PubMed:22347366, PubMed:23300529). Required forGDF2/BMP9 signaling through SMAD1 in endothelial cells andmodulates TGFB1 signaling through SMAD3 (PubMed:21737454,PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961,ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454,ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484,ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. | Polynucleotide 5'-kinase involved in rRNA processing.The kinase activity is required for the processing of the 32Sprecursor into 5.8S and 28S rRNAs, more specifically for thegeneration of the major 5.8S(S) form. In vitro, has both DNA andRNA 5'-kinase activities. Probably binds RNA.{ECO:0000269|PubMed:21063389}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 336_576 | 580 | 626 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 336_576 | 580 | 659 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 363_533 | 580 | 626 | Domain | ZP |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 363_533 | 580 | 659 | Domain | ZP |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 399_401 | 580 | 626 | Motif | Cell attachment site |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 399_401 | 580 | 659 | Motif | Cell attachment site |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 200_330 | 580 | 626 | Region | OR1%2C C-terminal part |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 26_46 | 580 | 626 | Region | OR1%2C N-terminal part |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 47_199 | 580 | 626 | Region | OR2 |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 200_330 | 580 | 659 | Region | OR1%2C C-terminal part |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 26_46 | 580 | 659 | Region | OR1%2C N-terminal part |
| Hgene | ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 47_199 | 580 | 659 | Region | OR2 |
| Tgene | >NOL9 | chr9:130579428 | chr1:6604982 | ENST00000377705 | - | 3 | 12 | 306_313 | 293 | 703 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 26_586 | 580 | 626 | Topological domain | Extracellular |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 612_658 | 580 | 626 | Topological domain | Cytoplasmic |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 26_586 | 580 | 659 | Topological domain | Extracellular |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 612_658 | 580 | 659 | Topological domain | Cytoplasmic |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000344849 | - | 13 | 14 | 587_611 | 580 | 626 | Transmembrane | Helical |
| Hgene | >ENG | chr9:130579428 | chr1:6604982 | ENST00000373203 | - | 13 | 15 | 587_611 | 580 | 659 | Transmembrane | Helical |
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FusionGeneSequence for ENG_NOL9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ENG_ENST00000373203_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_990aa MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGT WPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLS FCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQ IWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQ TKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSF QLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVP IPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSEEVDGCPVILVCGSQDVGKSTFNRYLINHLLNSLPCVDYLECDLGQTEFT PPGCISLLNITEPVLGPPFTHLRTPQKMVYYGKPSCKNNYENYIDIVKYVFSAYKRESPLIVNTMGWVSDQGLLLLIDLIRLLSPSHVVQ FRSDHSKYMPDLTPQYVDDMDGLYTKSKTKMRNRRFRLAAFADALEFADEEKESPVEFTGHKLIGVYTDFAFRITPRNRESHNKILRDLS ILSYLSQLQPPMPKPLSPLHSLTPYQVPFNAVALRITHSDVAPTHILYAVNASWVGLCKIQDDVRGYTNGPILLAQTPICDCLGFGICRG IDMEKRLYHILTPVPPEELRTVNCLLVGAIAIPHCVLKCQRGIEGTVPYVTTDYNFKLPGASEKIGAREPEEAHKEKPYRRPKFCRKMKX >In-frame_ENG_ENST00000344849_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_990aa MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGT WPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLS FCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQ IWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQ TKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSF QLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVP IPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSEEVDGCPVILVCGSQDVGKSTFNRYLINHLLNSLPCVDYLECDLGQTEFT PPGCISLLNITEPVLGPPFTHLRTPQKMVYYGKPSCKNNYENYIDIVKYVFSAYKRESPLIVNTMGWVSDQGLLLLIDLIRLLSPSHVVQ FRSDHSKYMPDLTPQYVDDMDGLYTKSKTKMRNRRFRLAAFADALEFADEEKESPVEFTGHKLIGVYTDFAFRITPRNRESHNKILRDLS ILSYLSQLQPPMPKPLSPLHSLTPYQVPFNAVALRITHSDVAPTHILYAVNASWVGLCKIQDDVRGYTNGPILLAQTPICDCLGFGICRG IDMEKRLYHILTPVPPEELRTVNCLLVGAIAIPHCVLKCQRGIEGTVPYVTTDYNFKLPGASEKIGAREPEEAHKEKPYRRPKFCRKMKX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ENG_ENST00000373203_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_2970nt ATGGACCGCGGCACGCTCCCTCTGGCTGTTGCCCTGCTGCTGGCCAGCTGCAGCCTCAGCCCCACAAGTCTTGCAGAAACAGTCCATTGT GACCTTCAGCCTGTGGGCCCCGAGAGGGGCGAGGTGACATATACCACTAGCCAGGTCTCGAAGGGCTGCGTGGCTCAGGCCCCCAATGCC ATCCTTGAAGTCCATGTCCTCTTCCTGGAGTTCCCAACGGGCCCGTCACAGCTGGAGCTGACTCTCCAGGCATCCAAGCAAAATGGCACC TGGCCCCGAGAGGTGCTTCTGGTCCTCAGTGTAAACAGCAGTGTCTTCCTGCATCTCCAGGCCCTGGGAATCCCACTGCACTTGGCCTAC AATTCCAGCCTGGTCACCTTCCAAGAGCCCCCGGGGGTCAACACCACAGAGCTGCCATCCTTCCCCAAGACCCAGATCCTTGAGTGGGCA GCTGAGAGGGGCCCCATCACCTCTGCTGCTGAGCTGAATGACCCCCAGAGCATCCTCCTCCGACTGGGCCAAGCCCAGGGGTCACTGTCC TTCTGCATGCTGGAAGCCAGCCAGGACATGGGCCGCACGCTCGAGTGGCGGCCGCGTACTCCAGCCTTGGTCCGGGGCTGCCACTTGGAA GGCGTGGCCGGCCACAAGGAGGCGCACATCCTGAGGGTCCTGCCGGGCCACTCGGCCGGGCCCCGGACGGTGACGGTGAAGGTGGAACTG AGCTGCGCACCCGGGGATCTCGATGCCGTCCTCATCCTGCAGGGTCCCCCCTACGTGTCCTGGCTCATCGACGCCAACCACAACATGCAG ATCTGGACCACTGGAGAATACTCCTTCAAGATCTTTCCAGAGAAAAACATTCGTGGCTTCAAGCTCCCAGACACACCTCAAGGCCTCCTG GGGGAGGCCCGGATGCTCAATGCCAGCATTGTGGCATCCTTCGTGGAGCTACCGCTGGCCAGCATTGTCTCACTTCATGCCTCCAGCTGC GGTGGTAGGCTGCAGACCTCACCCGCACCGATCCAGACCACTCCTCCCAAGGACACTTGTAGCCCGGAGCTGCTCATGTCCTTGATCCAG ACAAAGTGTGCCGACGACGCCATGACCCTGGTACTAAAGAAAGAGCTTGTTGCGCATTTGAAGTGCACCATCACGGGCCTGACCTTCTGG GACCCCAGCTGTGAGGCAGAGGACAGGGGTGACAAGTTTGTCTTGCGCAGTGCTTACTCCAGCTGTGGCATGCAGGTGTCAGCAAGTATG ATCAGCAATGAGGCGGTGGTCAATATCCTGTCGAGCTCATCACCACAGCGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTC CAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCC CCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGG GCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCC ATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATG CGCTTGAACATCATCAGCCCTGACCTGTCTGAAGAAGTAGATGGCTGCCCTGTCATTCTAGTTTGTGGATCCCAGGATGTTGGAAAGTCA ACATTTAATAGATACCTGATTAACCATTTGTTAAATAGTCTTCCCTGCGTTGACTATTTGGAATGTGATCTGGGACAGACAGAATTTACC CCTCCTGGTTGCATTTCTTTGCTTAATATTACAGAACCAGTTCTGGGACCACCTTTCACTCACCTGAGGACTCCACAGAAGATGGTATAT TATGGGAAACCTTCTTGTAAAAACAACTATGAGAATTATATTGACATAGTGAAATATGTGTTCAGCGCTTACAAGAGAGAGTCCCCTCTC ATCGTCAACACTATGGGATGGGTTTCAGACCAGGGGCTCCTGCTTCTCATTGATCTGATCCGATTGCTGTCTCCCAGCCACGTGGTTCAG TTCCGCTCTGACCACAGTAAATATATGCCAGACCTTACCCCGCAGTATGTAGATGACATGGATGGCTTGTACACAAAAAGCAAGACCAAG ATGAGAAATCGACGTTTCAGACTCGCAGCATTTGCAGATGCTTTGGAATTTGCTGATGAAGAAAAAGAGAGTCCAGTTGAGTTCACTGGA CATAAACTGATAGGTGTTTATACAGACTTTGCATTCAGAATAACTCCAAGAAATAGAGAGTCACATAACAAAATTCTTCGAGATCTGTCC ATCTTGAGTTACCTTAGCCAGCTGCAGCCCCCGATGCCCAAACCACTTTCTCCTTTACATAGCCTGACACCCTATCAGGTCCCTTTCAAT GCAGTCGCACTCCGGATTACCCACTCTGATGTCGCCCCTACCCATATACTATATGCTGTAAACGCCAGCTGGGTTGGTCTTTGCAAGATC CAGGATGACGTCAGAGGATACACGAATGGGCCCATCCTGCTTGCCCAGACTCCAATCTGTGACTGCTTGGGCTTTGGCATCTGTAGAGGC ATTGACATGGAGAAGCGGCTGTACCACATCCTCACCCCTGTGCCCCCGGAAGAGCTAAGGACCGTGAATTGTCTGCTCGTTGGAGCTATT GCCATTCCACATTGTGTCCTTAAGTGCCAGCGTGGGATCGAAGGGACAGTACCTTATGTCACAACGGATTACAATTTTAAACTTCCTGGA GCATCAGAGAAAATTGGAGCAAGAGAACCTGAGGAGGCACATAAAGAGAAACCATACCGAAGACCTAAGTTCTGTCGAAAAATGAAGTGA >In-frame_ENG_ENST00000344849_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_2970nt ATGGACCGCGGCACGCTCCCTCTGGCTGTTGCCCTGCTGCTGGCCAGCTGCAGCCTCAGCCCCACAAGTCTTGCAGAAACAGTCCATTGT GACCTTCAGCCTGTGGGCCCCGAGAGGGGCGAGGTGACATATACCACTAGCCAGGTCTCGAAGGGCTGCGTGGCTCAGGCCCCCAATGCC ATCCTTGAAGTCCATGTCCTCTTCCTGGAGTTCCCAACGGGCCCGTCACAGCTGGAGCTGACTCTCCAGGCATCCAAGCAAAATGGCACC TGGCCCCGAGAGGTGCTTCTGGTCCTCAGTGTAAACAGCAGTGTCTTCCTGCATCTCCAGGCCCTGGGAATCCCACTGCACTTGGCCTAC AATTCCAGCCTGGTCACCTTCCAAGAGCCCCCGGGGGTCAACACCACAGAGCTGCCATCCTTCCCCAAGACCCAGATCCTTGAGTGGGCA GCTGAGAGGGGCCCCATCACCTCTGCTGCTGAGCTGAATGACCCCCAGAGCATCCTCCTCCGACTGGGCCAAGCCCAGGGGTCACTGTCC TTCTGCATGCTGGAAGCCAGCCAGGACATGGGCCGCACGCTCGAGTGGCGGCCGCGTACTCCAGCCTTGGTCCGGGGCTGCCACTTGGAA GGCGTGGCCGGCCACAAGGAGGCGCACATCCTGAGGGTCCTGCCGGGCCACTCGGCCGGGCCCCGGACGGTGACGGTGAAGGTGGAACTG AGCTGCGCACCCGGGGATCTCGATGCCGTCCTCATCCTGCAGGGTCCCCCCTACGTGTCCTGGCTCATCGACGCCAACCACAACATGCAG ATCTGGACCACTGGAGAATACTCCTTCAAGATCTTTCCAGAGAAAAACATTCGTGGCTTCAAGCTCCCAGACACACCTCAAGGCCTCCTG GGGGAGGCCCGGATGCTCAATGCCAGCATTGTGGCATCCTTCGTGGAGCTACCGCTGGCCAGCATTGTCTCACTTCATGCCTCCAGCTGC GGTGGTAGGCTGCAGACCTCACCCGCACCGATCCAGACCACTCCTCCCAAGGACACTTGTAGCCCGGAGCTGCTCATGTCCTTGATCCAG ACAAAGTGTGCCGACGACGCCATGACCCTGGTACTAAAGAAAGAGCTTGTTGCGCATTTGAAGTGCACCATCACGGGCCTGACCTTCTGG GACCCCAGCTGTGAGGCAGAGGACAGGGGTGACAAGTTTGTCTTGCGCAGTGCTTACTCCAGCTGTGGCATGCAGGTGTCAGCAAGTATG ATCAGCAATGAGGCGGTGGTCAATATCCTGTCGAGCTCATCACCACAGCGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTC CAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCC CCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGG GCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCC ATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATG CGCTTGAACATCATCAGCCCTGACCTGTCTGAAGAAGTAGATGGCTGCCCTGTCATTCTAGTTTGTGGATCCCAGGATGTTGGAAAGTCA ACATTTAATAGATACCTGATTAACCATTTGTTAAATAGTCTTCCCTGCGTTGACTATTTGGAATGTGATCTGGGACAGACAGAATTTACC CCTCCTGGTTGCATTTCTTTGCTTAATATTACAGAACCAGTTCTGGGACCACCTTTCACTCACCTGAGGACTCCACAGAAGATGGTATAT TATGGGAAACCTTCTTGTAAAAACAACTATGAGAATTATATTGACATAGTGAAATATGTGTTCAGCGCTTACAAGAGAGAGTCCCCTCTC ATCGTCAACACTATGGGATGGGTTTCAGACCAGGGGCTCCTGCTTCTCATTGATCTGATCCGATTGCTGTCTCCCAGCCACGTGGTTCAG TTCCGCTCTGACCACAGTAAATATATGCCAGACCTTACCCCGCAGTATGTAGATGACATGGATGGCTTGTACACAAAAAGCAAGACCAAG ATGAGAAATCGACGTTTCAGACTCGCAGCATTTGCAGATGCTTTGGAATTTGCTGATGAAGAAAAAGAGAGTCCAGTTGAGTTCACTGGA CATAAACTGATAGGTGTTTATACAGACTTTGCATTCAGAATAACTCCAAGAAATAGAGAGTCACATAACAAAATTCTTCGAGATCTGTCC ATCTTGAGTTACCTTAGCCAGCTGCAGCCCCCGATGCCCAAACCACTTTCTCCTTTACATAGCCTGACACCCTATCAGGTCCCTTTCAAT GCAGTCGCACTCCGGATTACCCACTCTGATGTCGCCCCTACCCATATACTATATGCTGTAAACGCCAGCTGGGTTGGTCTTTGCAAGATC CAGGATGACGTCAGAGGATACACGAATGGGCCCATCCTGCTTGCCCAGACTCCAATCTGTGACTGCTTGGGCTTTGGCATCTGTAGAGGC ATTGACATGGAGAAGCGGCTGTACCACATCCTCACCCCTGTGCCCCCGGAAGAGCTAAGGACCGTGAATTGTCTGCTCGTTGGAGCTATT GCCATTCCACATTGTGTCCTTAAGTGCCAGCGTGGGATCGAAGGGACAGTACCTTATGTCACAACGGATTACAATTTTAAACTTCCTGGA GCATCAGAGAAAATTGGAGCAAGAGAACCTGAGGAGGCACATAAAGAGAAACCATACCGAAGACCTAAGTTCTGTCGAAAAATGAAGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ENG_ENST00000373203_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_7878nt GGCAGGCGGCCTGGCCCAGCCCCTTCTCTAAGGAAGCGCATTTCCTGCCTCCCTGGGCCGGCCGGGCTGGATGAGCCAGGAGCTCCCTGC TGCCGGTCATACCACAGCCTTCATCTGCGCCCTGGGGCCAGGACTGCTGCTGTCACTGCCATCCATTGGAGCCCAGCACCCCCTCCCCGC CCATCCTTCGGACAGCAACTCCAGCCCAGCCCCGCGTCCCTGTGTCCACTTCTCCTGACCCCTCGGCCGCCACCCCAGAAGGCTGGAGCA GGGACGCCGTCGCTCCGGCCGCCTGCTCCCCTCGGGTCCCCGTGCGAGCCCACGCCGGCCCCGGTGCCCGCCCGCAGCCCTGCCACTGGA CACAGGATAAGGCCCAGCGCACAGGCCCCCACGTGGACAGCATGGACCGCGGCACGCTCCCTCTGGCTGTTGCCCTGCTGCTGGCCAGCT GCAGCCTCAGCCCCACAAGTCTTGCAGAAACAGTCCATTGTGACCTTCAGCCTGTGGGCCCCGAGAGGGGCGAGGTGACATATACCACTA GCCAGGTCTCGAAGGGCTGCGTGGCTCAGGCCCCCAATGCCATCCTTGAAGTCCATGTCCTCTTCCTGGAGTTCCCAACGGGCCCGTCAC AGCTGGAGCTGACTCTCCAGGCATCCAAGCAAAATGGCACCTGGCCCCGAGAGGTGCTTCTGGTCCTCAGTGTAAACAGCAGTGTCTTCC TGCATCTCCAGGCCCTGGGAATCCCACTGCACTTGGCCTACAATTCCAGCCTGGTCACCTTCCAAGAGCCCCCGGGGGTCAACACCACAG AGCTGCCATCCTTCCCCAAGACCCAGATCCTTGAGTGGGCAGCTGAGAGGGGCCCCATCACCTCTGCTGCTGAGCTGAATGACCCCCAGA GCATCCTCCTCCGACTGGGCCAAGCCCAGGGGTCACTGTCCTTCTGCATGCTGGAAGCCAGCCAGGACATGGGCCGCACGCTCGAGTGGC GGCCGCGTACTCCAGCCTTGGTCCGGGGCTGCCACTTGGAAGGCGTGGCCGGCCACAAGGAGGCGCACATCCTGAGGGTCCTGCCGGGCC ACTCGGCCGGGCCCCGGACGGTGACGGTGAAGGTGGAACTGAGCTGCGCACCCGGGGATCTCGATGCCGTCCTCATCCTGCAGGGTCCCC CCTACGTGTCCTGGCTCATCGACGCCAACCACAACATGCAGATCTGGACCACTGGAGAATACTCCTTCAAGATCTTTCCAGAGAAAAACA TTCGTGGCTTCAAGCTCCCAGACACACCTCAAGGCCTCCTGGGGGAGGCCCGGATGCTCAATGCCAGCATTGTGGCATCCTTCGTGGAGC TACCGCTGGCCAGCATTGTCTCACTTCATGCCTCCAGCTGCGGTGGTAGGCTGCAGACCTCACCCGCACCGATCCAGACCACTCCTCCCA AGGACACTTGTAGCCCGGAGCTGCTCATGTCCTTGATCCAGACAAAGTGTGCCGACGACGCCATGACCCTGGTACTAAAGAAAGAGCTTG TTGCGCATTTGAAGTGCACCATCACGGGCCTGACCTTCTGGGACCCCAGCTGTGAGGCAGAGGACAGGGGTGACAAGTTTGTCTTGCGCA GTGCTTACTCCAGCTGTGGCATGCAGGTGTCAGCAAGTATGATCAGCAATGAGGCGGTGGTCAATATCCTGTCGAGCTCATCACCACAGC GGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCA TCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACT TGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTG ACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGA CCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGAAGAAGTAGATGGCTGCC CTGTCATTCTAGTTTGTGGATCCCAGGATGTTGGAAAGTCAACATTTAATAGATACCTGATTAACCATTTGTTAAATAGTCTTCCCTGCG TTGACTATTTGGAATGTGATCTGGGACAGACAGAATTTACCCCTCCTGGTTGCATTTCTTTGCTTAATATTACAGAACCAGTTCTGGGAC CACCTTTCACTCACCTGAGGACTCCACAGAAGATGGTATATTATGGGAAACCTTCTTGTAAAAACAACTATGAGAATTATATTGACATAG TGAAATATGTGTTCAGCGCTTACAAGAGAGAGTCCCCTCTCATCGTCAACACTATGGGATGGGTTTCAGACCAGGGGCTCCTGCTTCTCA TTGATCTGATCCGATTGCTGTCTCCCAGCCACGTGGTTCAGTTCCGCTCTGACCACAGTAAATATATGCCAGACCTTACCCCGCAGTATG TAGATGACATGGATGGCTTGTACACAAAAAGCAAGACCAAGATGAGAAATCGACGTTTCAGACTCGCAGCATTTGCAGATGCTTTGGAAT TTGCTGATGAAGAAAAAGAGAGTCCAGTTGAGTTCACTGGACATAAACTGATAGGTGTTTATACAGACTTTGCATTCAGAATAACTCCAA GAAATAGAGAGTCACATAACAAAATTCTTCGAGATCTGTCCATCTTGAGTTACCTTAGCCAGCTGCAGCCCCCGATGCCCAAACCACTTT CTCCTTTACATAGCCTGACACCCTATCAGGTCCCTTTCAATGCAGTCGCACTCCGGATTACCCACTCTGATGTCGCCCCTACCCATATAC TATATGCTGTAAACGCCAGCTGGGTTGGTCTTTGCAAGATCCAGGATGACGTCAGAGGATACACGAATGGGCCCATCCTGCTTGCCCAGA CTCCAATCTGTGACTGCTTGGGCTTTGGCATCTGTAGAGGCATTGACATGGAGAAGCGGCTGTACCACATCCTCACCCCTGTGCCCCCGG AAGAGCTAAGGACCGTGAATTGTCTGCTCGTTGGAGCTATTGCCATTCCACATTGTGTCCTTAAGTGCCAGCGTGGGATCGAAGGGACAG TACCTTATGTCACAACGGATTACAATTTTAAACTTCCTGGAGCATCAGAGAAAATTGGAGCAAGAGAACCTGAGGAGGCACATAAAGAGA AACCATACCGAAGACCTAAGTTCTGTCGAAAAATGAAGTGATGCTCGCGTTTTTAATAAGGGAAGAAACTTTCCTACCAGAAAGCTTTGT CTCAAGCCTGACCACAAGAGACATGATGGAGTTTCATGGCCATGAATGGTGCCCTTATTAGCAACAGTGTTTTTTGTGTAATTCGTGAAT GTCATATAGTAGTCTTAAGTTTCTCTTTTAAAGCTGCATGAGCTAGAATTTGTTCTAGTCTTCTGTGTGATACTCATACTTGCTGTCCAG AGGGAGTAAAACAGCAGAGAACAGTTTGTGTGCCATTAAAACAGAGATTCCTCAGAAAGTTCTTCAGGGACCTGGTTATTAGAATCAGGA TAAAAATAAGGAAACTGGGGCCATTACAATGTACCGAGAAGGAAGGAAGAAGGCCGACCTGCAGGATCTCAAGCATAATGGATACAAGGG CTCGCCACGGGCCTTGCCTGAGCCATGTGCAGAGCTGGGGTCCAGCGGTCTGCTTCCTTGGAGCCAGTGTGGATGGTTACAGCCCATCCA TTTGGTGCAGTTGTACTTGGTCTGTTATATTCAATCAAGGTTTAATAGATAGGGCTGGGCATGGTGGCTCATGCACACCTGTAATCCTAG CACTTTGGGAGGCTGAGGCGGGAGGATTGCTTGAGCCTCGGAGTTCCAGGCTGGAGTACACCAACTACTCCAGCCTGAGCGACAGAGTAA GACCTTATCTTTTAAAAAAGAAAAGAAAAATTTAAACGGGTTTGATAGATATAAATTTGGACCCAAGAGCCCTTCCTTTTTTTTAATCCT GAGGTTTTATGCTGAGGAAATTTCTTTCAAATCTGGAAAACCTCGGGGCCAGGCGCAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGA GGCCAAGGCAGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACTCCGTCTCTACTAAAAATACAAAAAACT AGCTGGGCGTGGTGGTGGGCGCCTATAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCGGAGCTTGCAG TGAGCCGAGGTCACGCCACTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCATCTCAAAAAAAAAAAATAATAATCTGGAAAACCTCT TCTGGGGGCTCTTATAAAAGTAGATTTGTCCAAATTGACTTCTGATCTGAGGCCAGAGACAACCACAGGGCAGAGCTGGAGACTGGGCTG TTTTGAAGGAAGAAGGACTGGCAGACCAGCTCTTGGGAAAGCTCCATTATTGCCTGTGGGAGGCTGGACCTGAACTTGCACCTATGAACA ACCCTGCCATTTAGAGCTTTTTCCTGGGGGTGCCGGCGGCTGGTGACCAGACTGCCATTCTCCACGTTCTCCCTGGTGCTTCCGACTCTG TCCTCTAGGTTGGAAGTGGTTTGTGTAAACGGGTGATGGGACCAGGTCACATCATTTCTGCATTTAAGACAGCAGGATACTTCCTGGGGC TGAGGTTCAAACTGGTATTGTGACCACCGCTTTGACAGAATTCCATCTTCCCAGCATGATCACATTGTAAGACTATTAGGATGTGTGGGT TTTAACACTTATATACACTTATACAACTGTTGGTTATCATTGTCTTTAGTATTTTACAGTGGCCCCTCAGCACCTCTTAGACCCAACAGC AAAGGACTTAAAATAAGCACAGGAAACCTTGCTATGGTGATTAGTTTTGATACCTTTGAGACAATTGAGTCTAGCTTCTTAGTTGCCCCT TATTTATGTTGAAATCTGGCTCATTCATATGATGTTTTACTGTGCTGGCCTTGTAAAGAATTTTAAGACAATCCATCACCATCAATGTTT TGCCTTTCTCCACTTTCGTGTATCTTACAGTTATACTCACTGGAGGTCATTTGCAGCAAGGCTCTGGAAGAATGAAACTGGTGCCCTGTA ATTGCATTTGCATTCAATCTAGGTTTGCCTTCAGGCTTTAAATGCGGCCTGTATGAAGGTCAAGTCTTTTTCTTCAGTCCCTATCAGTAA AGAAAAATCGTTGCCTCTAGAGGGAGCTATCAGCTGTGGGTCAGGTGGCCGTACTGGGGCTAGAGTTGGCCCAGGAAGCTGTACAGGGTT TAGGGAAGGAGGTTCGGAGACAGGGAGCCAAGGCCTCTGTCAGGTCTAGCTTGTGCCGGTCAGACCTGCAGCAGCACCATTCTCCAGGAT GACAATTCATCCCATTATTGATGGCAGTGGCCTTTTTATCCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCC CAGGCTGGAGTGCAGTGGCGCAATCTGGGCTCACTGCCACCTCCGCCTCCCGGGTTCAAGTGATTCTCTTGCCTCAACCTCCCGAGTAGC TGGGATTACAGGCATGCGCCACCATGCCTGGCTGATTTTCTATTTTTAGTAGAGAAGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAA CTCCTGTCCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCGCACCCGGCTGGTGGCAGTGGCT TTAAGGGCATTTAGAAGAAGGACAAGATTGGACTTTTTATCATTTCCACAGTCTGTTATGGGTCAGATTAGGTAGTAAGGAGTTCTCCAT TGGAGCTATTCTTTTTTTTTTTTCTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGGGTGCAGTGGCACGACCTTGGCTCA CTACAGCCTCTCCCCTCCCGGGTTCAAGTGATTCTTCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAGGTGAGCGCCACCATGCCTGGC TAATTTTTATATTTTTAGTAGAGATAGGGTTTCACCGTATTGGCTAGGCTGGTCTCGATCTCCTGACCTTGTGATCCGCTTGCCTCGGCC TCCCAAAGTGCTGAAGCAATTTCTTTTTTTTTTTTTTTTTTGAGACAGAGTCTAGCTCTGTCGCCCAGGCTGGGGTGCAGTGGAGTGATC TCGGCTCACTGCAACTTCCGCCTCCCAGGTTTAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTATGCCACCAC GCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCGC CTTGGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCTGGCCTGAAGCTATTCTTTACAAAAGCTCTTAGTTTTTGTTTGT TTGTTTGTTTTTTTCTTTTGCGACGGACTCTCTGTCGCCAAGGCTGGAGTGCAGTGGCCTGATCTCAGGTCACTGCAACCTCTGCCTCCT GGGTTCAAGCGATTCTCCTGCTTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGT AGAGATGGCGTTTCACTTTATTGGTCAGGCTGGTCTCGAACTTCCAACCTCAGGGGATCCGCCTGCCTTGGCCTCCCAAGGTGTTGGGAT TACAGGCATAAGACACTGTGCCTGGGCCTCTTAGTAATTTTTGTATGTAATTTTCAAAGTATCCGGGATTACAGGCGCCCGCCACTACAC TAGCTAATTTTTTTTGTATTTTTAGTAGAGATGGGGTTTTACTATGTTGGCTAGGCTGGTCTCGAGCTCCTGACCTCGTGATCCGTCCAC CTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTAGGTCATTTGTTTTTGGGTTTGGATGGCAAGATCATGG ATAAGACAGCAGGCTTTGATTATAGAGCTCTGAGTTCAAATCCTGGCTCTACCACTTGTCAGTGGTGTAACTTGGAGGAAGATGCTTAGC CTGAGCCTGTTTTATGTTTTGAAGATTGGGTAATTGTCCTTCCTTCAGTGTTCCTGGGTGAGGAGTAAGTGAAGTCATGTCTATAAGAGA TGTAGCACAGTCTCCGGCATGTAGAAACGGTCAGTAACTCCTAGTGTGTAGCTAGCCTCTGATGAGATGGTAAACTCAGGAGGCTGGCAC CACGGCTGTGCTACTCACGGTCATGCTGGAGGGATGCAGAAACTAAATGAATCCACAGCTACTTACTCATCTTGCCTCTGGCAGGTTCAC CTTAAAATTGTTGCTACCAAGCTTCCTGTGGTCAAAGAGCCCTTGAGGAAGCAAGCTCCACGGCCACCATAGATAACCCATTCCTGAAAG TTTTTCATAAACCCCCACTTGTTGCTTTTAAAATTTTATAAGCAGCTTACACATGTAGAAAATGATCCTCCAGCCCACCACCACATAGTA ATCACTGACACTGTGAGGTGTCTCAGCTGGGGTTCTGCTGTGTGTGTGTGTATTTTACAAAATATGTATGGTTTCTGTTCAGCTCTTTTC >In-frame_ENG_ENST00000344849_chr9_130579428_-_NOL9_ENST00000377705_chr1_6604982_-_7758nt CCTGGGGCCAGGACTGCTGCTGTCACTGCCATCCATTGGAGCCCAGCACCCCCTCCCCGCCCATCCTTCGGACAGCAACTCCAGCCCAGC CCCGCGTCCCTGTGTCCACTTCTCCTGACCCCTCGGCCGCCACCCCAGAAGGCTGGAGCAGGGACGCCGTCGCTCCGGCCGCCTGCTCCC CTCGGGTCCCCGTGCGAGCCCACGCCGGCCCCGGTGCCCGCCCGCAGCCCTGCCACTGGACACAGGATAAGGCCCAGCGCACAGGCCCCC ACGTGGACAGCATGGACCGCGGCACGCTCCCTCTGGCTGTTGCCCTGCTGCTGGCCAGCTGCAGCCTCAGCCCCACAAGTCTTGCAGAAA CAGTCCATTGTGACCTTCAGCCTGTGGGCCCCGAGAGGGGCGAGGTGACATATACCACTAGCCAGGTCTCGAAGGGCTGCGTGGCTCAGG CCCCCAATGCCATCCTTGAAGTCCATGTCCTCTTCCTGGAGTTCCCAACGGGCCCGTCACAGCTGGAGCTGACTCTCCAGGCATCCAAGC AAAATGGCACCTGGCCCCGAGAGGTGCTTCTGGTCCTCAGTGTAAACAGCAGTGTCTTCCTGCATCTCCAGGCCCTGGGAATCCCACTGC ACTTGGCCTACAATTCCAGCCTGGTCACCTTCCAAGAGCCCCCGGGGGTCAACACCACAGAGCTGCCATCCTTCCCCAAGACCCAGATCC TTGAGTGGGCAGCTGAGAGGGGCCCCATCACCTCTGCTGCTGAGCTGAATGACCCCCAGAGCATCCTCCTCCGACTGGGCCAAGCCCAGG GGTCACTGTCCTTCTGCATGCTGGAAGCCAGCCAGGACATGGGCCGCACGCTCGAGTGGCGGCCGCGTACTCCAGCCTTGGTCCGGGGCT GCCACTTGGAAGGCGTGGCCGGCCACAAGGAGGCGCACATCCTGAGGGTCCTGCCGGGCCACTCGGCCGGGCCCCGGACGGTGACGGTGA AGGTGGAACTGAGCTGCGCACCCGGGGATCTCGATGCCGTCCTCATCCTGCAGGGTCCCCCCTACGTGTCCTGGCTCATCGACGCCAACC ACAACATGCAGATCTGGACCACTGGAGAATACTCCTTCAAGATCTTTCCAGAGAAAAACATTCGTGGCTTCAAGCTCCCAGACACACCTC AAGGCCTCCTGGGGGAGGCCCGGATGCTCAATGCCAGCATTGTGGCATCCTTCGTGGAGCTACCGCTGGCCAGCATTGTCTCACTTCATG CCTCCAGCTGCGGTGGTAGGCTGCAGACCTCACCCGCACCGATCCAGACCACTCCTCCCAAGGACACTTGTAGCCCGGAGCTGCTCATGT CCTTGATCCAGACAAAGTGTGCCGACGACGCCATGACCCTGGTACTAAAGAAAGAGCTTGTTGCGCATTTGAAGTGCACCATCACGGGCC TGACCTTCTGGGACCCCAGCTGTGAGGCAGAGGACAGGGGTGACAAGTTTGTCTTGCGCAGTGCTTACTCCAGCTGTGGCATGCAGGTGT CAGCAAGTATGATCAGCAATGAGGCGGTGGTCAATATCCTGTCGAGCTCATCACCACAGCGGAAAAAGGTGCACTGCCTCAACATGGACA GCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGG TCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCA TCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCT ACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGA CTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGAAGAAGTAGATGGCTGCCCTGTCATTCTAGTTTGTGGATCCCAGGATG TTGGAAAGTCAACATTTAATAGATACCTGATTAACCATTTGTTAAATAGTCTTCCCTGCGTTGACTATTTGGAATGTGATCTGGGACAGA CAGAATTTACCCCTCCTGGTTGCATTTCTTTGCTTAATATTACAGAACCAGTTCTGGGACCACCTTTCACTCACCTGAGGACTCCACAGA AGATGGTATATTATGGGAAACCTTCTTGTAAAAACAACTATGAGAATTATATTGACATAGTGAAATATGTGTTCAGCGCTTACAAGAGAG AGTCCCCTCTCATCGTCAACACTATGGGATGGGTTTCAGACCAGGGGCTCCTGCTTCTCATTGATCTGATCCGATTGCTGTCTCCCAGCC ACGTGGTTCAGTTCCGCTCTGACCACAGTAAATATATGCCAGACCTTACCCCGCAGTATGTAGATGACATGGATGGCTTGTACACAAAAA GCAAGACCAAGATGAGAAATCGACGTTTCAGACTCGCAGCATTTGCAGATGCTTTGGAATTTGCTGATGAAGAAAAAGAGAGTCCAGTTG AGTTCACTGGACATAAACTGATAGGTGTTTATACAGACTTTGCATTCAGAATAACTCCAAGAAATAGAGAGTCACATAACAAAATTCTTC GAGATCTGTCCATCTTGAGTTACCTTAGCCAGCTGCAGCCCCCGATGCCCAAACCACTTTCTCCTTTACATAGCCTGACACCCTATCAGG TCCCTTTCAATGCAGTCGCACTCCGGATTACCCACTCTGATGTCGCCCCTACCCATATACTATATGCTGTAAACGCCAGCTGGGTTGGTC TTTGCAAGATCCAGGATGACGTCAGAGGATACACGAATGGGCCCATCCTGCTTGCCCAGACTCCAATCTGTGACTGCTTGGGCTTTGGCA TCTGTAGAGGCATTGACATGGAGAAGCGGCTGTACCACATCCTCACCCCTGTGCCCCCGGAAGAGCTAAGGACCGTGAATTGTCTGCTCG TTGGAGCTATTGCCATTCCACATTGTGTCCTTAAGTGCCAGCGTGGGATCGAAGGGACAGTACCTTATGTCACAACGGATTACAATTTTA AACTTCCTGGAGCATCAGAGAAAATTGGAGCAAGAGAACCTGAGGAGGCACATAAAGAGAAACCATACCGAAGACCTAAGTTCTGTCGAA AAATGAAGTGATGCTCGCGTTTTTAATAAGGGAAGAAACTTTCCTACCAGAAAGCTTTGTCTCAAGCCTGACCACAAGAGACATGATGGA GTTTCATGGCCATGAATGGTGCCCTTATTAGCAACAGTGTTTTTTGTGTAATTCGTGAATGTCATATAGTAGTCTTAAGTTTCTCTTTTA AAGCTGCATGAGCTAGAATTTGTTCTAGTCTTCTGTGTGATACTCATACTTGCTGTCCAGAGGGAGTAAAACAGCAGAGAACAGTTTGTG TGCCATTAAAACAGAGATTCCTCAGAAAGTTCTTCAGGGACCTGGTTATTAGAATCAGGATAAAAATAAGGAAACTGGGGCCATTACAAT GTACCGAGAAGGAAGGAAGAAGGCCGACCTGCAGGATCTCAAGCATAATGGATACAAGGGCTCGCCACGGGCCTTGCCTGAGCCATGTGC AGAGCTGGGGTCCAGCGGTCTGCTTCCTTGGAGCCAGTGTGGATGGTTACAGCCCATCCATTTGGTGCAGTTGTACTTGGTCTGTTATAT TCAATCAAGGTTTAATAGATAGGGCTGGGCATGGTGGCTCATGCACACCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGAGGATTGC TTGAGCCTCGGAGTTCCAGGCTGGAGTACACCAACTACTCCAGCCTGAGCGACAGAGTAAGACCTTATCTTTTAAAAAAGAAAAGAAAAA TTTAAACGGGTTTGATAGATATAAATTTGGACCCAAGAGCCCTTCCTTTTTTTTAATCCTGAGGTTTTATGCTGAGGAAATTTCTTTCAA ATCTGGAAAACCTCGGGGCCAGGCGCAGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGCAGGCGGTTCACGAGGTCAGGA GATTGAGACCATCCTGGCTAACACAGTGAAACTCCGTCTCTACTAAAAATACAAAAAACTAGCTGGGCGTGGTGGTGGGCGCCTATAGTC CCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGGTCACGCCACTGCACTCCAGC CTGGGCAACAAGAGCAAGACTCCATCTCAAAAAAAAAAAATAATAATCTGGAAAACCTCTTCTGGGGGCTCTTATAAAAGTAGATTTGTC CAAATTGACTTCTGATCTGAGGCCAGAGACAACCACAGGGCAGAGCTGGAGACTGGGCTGTTTTGAAGGAAGAAGGACTGGCAGACCAGC TCTTGGGAAAGCTCCATTATTGCCTGTGGGAGGCTGGACCTGAACTTGCACCTATGAACAACCCTGCCATTTAGAGCTTTTTCCTGGGGG TGCCGGCGGCTGGTGACCAGACTGCCATTCTCCACGTTCTCCCTGGTGCTTCCGACTCTGTCCTCTAGGTTGGAAGTGGTTTGTGTAAAC GGGTGATGGGACCAGGTCACATCATTTCTGCATTTAAGACAGCAGGATACTTCCTGGGGCTGAGGTTCAAACTGGTATTGTGACCACCGC TTTGACAGAATTCCATCTTCCCAGCATGATCACATTGTAAGACTATTAGGATGTGTGGGTTTTAACACTTATATACACTTATACAACTGT TGGTTATCATTGTCTTTAGTATTTTACAGTGGCCCCTCAGCACCTCTTAGACCCAACAGCAAAGGACTTAAAATAAGCACAGGAAACCTT GCTATGGTGATTAGTTTTGATACCTTTGAGACAATTGAGTCTAGCTTCTTAGTTGCCCCTTATTTATGTTGAAATCTGGCTCATTCATAT GATGTTTTACTGTGCTGGCCTTGTAAAGAATTTTAAGACAATCCATCACCATCAATGTTTTGCCTTTCTCCACTTTCGTGTATCTTACAG TTATACTCACTGGAGGTCATTTGCAGCAAGGCTCTGGAAGAATGAAACTGGTGCCCTGTAATTGCATTTGCATTCAATCTAGGTTTGCCT TCAGGCTTTAAATGCGGCCTGTATGAAGGTCAAGTCTTTTTCTTCAGTCCCTATCAGTAAAGAAAAATCGTTGCCTCTAGAGGGAGCTAT CAGCTGTGGGTCAGGTGGCCGTACTGGGGCTAGAGTTGGCCCAGGAAGCTGTACAGGGTTTAGGGAAGGAGGTTCGGAGACAGGGAGCCA AGGCCTCTGTCAGGTCTAGCTTGTGCCGGTCAGACCTGCAGCAGCACCATTCTCCAGGATGACAATTCATCCCATTATTGATGGCAGTGG CCTTTTTATCCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGCAATCTGGGC TCACTGCCACCTCCGCCTCCCGGGTTCAAGTGATTCTCTTGCCTCAACCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGCCTG GCTGATTTTCTATTTTTAGTAGAGAAGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTGTCCTCAGGTGATCCACCTGCCTTG GCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCGCACCCGGCTGGTGGCAGTGGCTTTAAGGGCATTTAGAAGAAGGACAAGATTG GACTTTTTATCATTTCCACAGTCTGTTATGGGTCAGATTAGGTAGTAAGGAGTTCTCCATTGGAGCTATTCTTTTTTTTTTTTCTTTTTT TTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGGGTGCAGTGGCACGACCTTGGCTCACTACAGCCTCTCCCCTCCCGGGTTCAAGTG ATTCTTCTGCCCCAGCCTCCCAAGTAGCTGGGATTACAGGTGAGCGCCACCATGCCTGGCTAATTTTTATATTTTTAGTAGAGATAGGGT TTCACCGTATTGGCTAGGCTGGTCTCGATCTCCTGACCTTGTGATCCGCTTGCCTCGGCCTCCCAAAGTGCTGAAGCAATTTCTTTTTTT TTTTTTTTTTTGAGACAGAGTCTAGCTCTGTCGCCCAGGCTGGGGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTCCGCCTCCCAGGT TTAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTATGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAG ACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCGCCTTGGCCTCCGAAAGTGCTGGGATTACAGG CGTGAGCCACTGCGCCTGGCCTGAAGCTATTCTTTACAAAAGCTCTTAGTTTTTGTTTGTTTGTTTGTTTTTTTCTTTTGCGACGGACTC TCTGTCGCCAAGGCTGGAGTGCAGTGGCCTGATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCTTCAGCCTC CCAAGTAGCTGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGCGTTTCACTTTATTGGTCAGGC TGGTCTCGAACTTCCAACCTCAGGGGATCCGCCTGCCTTGGCCTCCCAAGGTGTTGGGATTACAGGCATAAGACACTGTGCCTGGGCCTC TTAGTAATTTTTGTATGTAATTTTCAAAGTATCCGGGATTACAGGCGCCCGCCACTACACTAGCTAATTTTTTTTGTATTTTTAGTAGAG ATGGGGTTTTACTATGTTGGCTAGGCTGGTCTCGAGCTCCTGACCTCGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGG CGTGAGCCACCGCGCCCGGCCTAGGTCATTTGTTTTTGGGTTTGGATGGCAAGATCATGGATAAGACAGCAGGCTTTGATTATAGAGCTC TGAGTTCAAATCCTGGCTCTACCACTTGTCAGTGGTGTAACTTGGAGGAAGATGCTTAGCCTGAGCCTGTTTTATGTTTTGAAGATTGGG TAATTGTCCTTCCTTCAGTGTTCCTGGGTGAGGAGTAAGTGAAGTCATGTCTATAAGAGATGTAGCACAGTCTCCGGCATGTAGAAACGG TCAGTAACTCCTAGTGTGTAGCTAGCCTCTGATGAGATGGTAAACTCAGGAGGCTGGCACCACGGCTGTGCTACTCACGGTCATGCTGGA GGGATGCAGAAACTAAATGAATCCACAGCTACTTACTCATCTTGCCTCTGGCAGGTTCACCTTAAAATTGTTGCTACCAAGCTTCCTGTG GTCAAAGAGCCCTTGAGGAAGCAAGCTCCACGGCCACCATAGATAACCCATTCCTGAAAGTTTTTCATAAACCCCCACTTGTTGCTTTTA AAATTTTATAAGCAGCTTACACATGTAGAAAATGATCCTCCAGCCCACCACCACATAGTAATCACTGACACTGTGAGGTGTCTCAGCTGG GGTTCTGCTGTGTGTGTGTGTATTTTACAAAATATGTATGGTTTCTGTTCAGCTCTTTTCAGTTAACAGATGAACTTTTGTATCATTAAA 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FusionGenePPI for ENG_NOL9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ENG | TGFBR2, TGFBR1, ACVR1, ACVR2B, BMP7, BMP2, ACVR2A, TUFM, ACVRL1, TGFB3, TGFB1, ENG | NOL9 | SIRT7, BARD1, LAS1L, PELP1, SOX2, PASK, REL, TCF4, AHNAK, RNF2, BMI1, SUMO2, RPS2, WDR18, NTRK1, TEX10, IFI16, XPO1, FYCO1, FOXL1, FOXQ1, KCTD9, SENP3, MRS2, SHCBP1, ZNF638, IPO5, RANBP6, VPRBP, C1QBP, PHF10, KIAA0232, LTV1, JPH1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ENG_NOL9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ENG_NOL9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ENG | C0039445 | Hereditary hemorrhagic telangiectasia | 12 | CTD_human;ORPHANET;UNIPROT |
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