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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 11589

FusionGeneSummary for ENAH_SCCPDH

check button Fusion gene summary
Fusion gene informationFusion gene name: ENAH_SCCPDH
Fusion gene ID: 11589
HgeneTgene
Gene symbol

ENAH

SCCPDH

Gene ID

55740

51097

Gene nameENAH, actin regulatorsaccharopine dehydrogenase (putative)
SynonymsENA|MENA|NDPP1CGI-49|NET11
Cytomap

1q42.12

1q44

Type of geneprotein-codingprotein-coding
Descriptionprotein enabled homologenabled homologmammalian enabled variant 11amammalian enabled variant pansaccharopine dehydrogenase-like oxidoreductaseprobable saccharopine dehydrogenase
Modification date2018052020180523
UniProtAcc

Q8N8S7

Q8NBX0

Ensembl transtripts involved in fusion geneENST00000366844, ENST00000366843, 
ENST00000284563, ENST00000391874, 
ENST00000366510, 
Fusion gene scores* DoF score7 X 7 X 5=2456 X 7 X 3=126
# samples 105
** MAII scorelog2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/126*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENAH [Title/Abstract] AND SCCPDH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246907378

+
TCGALDSKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246921528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000366844ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
Frame-shiftENST00000366843ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
Frame-shiftENST00000284563ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
intron-3CDSENST00000391874ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
In-frameENST00000366844ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
In-frameENST00000366843ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
In-frameENST00000284563ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
intron-3CDSENST00000391874ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+

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FusionProtFeatures for ENAH_SCCPDH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENAH

Q8N8S7

SCCPDH

Q8NBX0

Ena/VASP proteins are actin-associated proteins involvedin a range of processes dependent on cytoskeleton remodeling andcell polarity such as axon guidance and lamellipodial andfilopodial dynamics in migrating cells. ENAH induces the formationof F-actin rich outgrowths in fibroblasts. Acts synergisticallywith BAIAP2-alpha and downstream of NTN1 to promote filipodiaformation (By similarity). {ECO:0000250,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114135_2651571Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114557_5871571Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115135_2651592Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115557_5871592Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114310_3731571Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115310_3731592Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-1141_1111571DomainWH1
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-1151_1111592DomainWH1
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114400_4031571MotifNote=KLKR
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115400_4031592MotifNote=KLKR
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114156_2001571RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114391_4111571RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114391_5881571RegionNote=EVH2
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114442_4591571RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114554_5881571RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115156_2001592RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115391_4111592RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115391_5881592RegionNote=EVH2
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115442_4591592RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115554_5881592RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114156_1601571RepeatNote=1
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114161_1651571RepeatNote=2
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114166_1701571RepeatNote=3
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114171_1751571RepeatNote=4
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114176_1801571RepeatNote=5
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114181_1851571RepeatNote=6
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114186_1901571RepeatNote=7
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114191_1951571RepeatNote=8
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114196_2001571RepeatNote=9
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115156_1601592RepeatNote=1
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115161_1651592RepeatNote=2
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115166_1701592RepeatNote=3
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115171_1751592RepeatNote=4
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115176_1801592RepeatNote=5
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115181_1851592RepeatNote=6
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115186_1901592RepeatNote=7
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115191_1951592RepeatNote=8
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115196_2001592RepeatNote=9


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FusionGeneSequence for ENAH_SCCPDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ENAH_ENST00000366844_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_243aa
MRGXAFMMVPGSQQFMVLEIRVIXENXEMYQIXNLSRSLVQNXREGGQFLIVGNSKVIPFLLWDLMCLLXGGLNVTCMKIXRNHQFSMLR
MXLWEASPLLLSXCLQDFSFCSLXGLELEGNFSXNSHGSSPLAIFQNKAQHKNRLMLPHSRXHSLVKDTAKALVQIRTNQISKFVLRXKD

>In-frame_ENAH_ENST00000366843_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_243aa
MRGXAFMMVPGSQQFMVLEIRVIXENXEMYQIXNLSRSLVQNXREGGQFLIVGNSKVIPFLLWDLMCLLXGGLNVTCMKIXRNHQFSMLR
MXLWEASPLLLSXCLQDFSFCSLXGLELEGNFSXNSHGSSPLAIFQNKAQHKNRLMLPHSRXHSLVKDTAKALVQIRTNQISKFVLRXKD

>In-frame_ENAH_ENST00000284563_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_243aa
MRGXAFMMVPGSQQFMVLEIRVIXENXEMYQIXNLSRSLVQNXREGGQFLIVGNSKVIPFLLWDLMCLLXGGLNVTCMKIXRNHQFSMLR
MXLWEASPLLLSXCLQDFSFCSLXGLELEGNFSXNSHGSSPLAIFQNKAQHKNRLMLPHSRXHSLVKDTAKALVQIRTNQISKFVLRXKD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ENAH_ENST00000366844_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_731nt
ATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTAT
CAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTC
CTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGT
ATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGC
AACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCA
CGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGAC
CAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCG
GGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCT

>In-frame_ENAH_ENST00000366843_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_731nt
ATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTAT
CAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTC
CTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGT
ATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGC
AACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCA
CGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGAC
CAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCG
GGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCT

>In-frame_ENAH_ENST00000284563_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_731nt
ATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTAT
CAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTC
CTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGT
ATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGC
AACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCA
CGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGAC
CAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCG
GGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ENAH_ENST00000366844_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_2020nt
GGTTCCTCGCGGCGATCCCGACTCTCCTCCCGCGGCTGCAGCAGCTGCCGGTTGCACACGGCCTCGGCGGCGGCGCGGCGAGCGCGGGCC
TGTGGAGCGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGA
GGTGGGAGGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACAC
TCCCGGCCGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAG
CTGCTCCCCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCA
CCATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGT
ATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCAT
TCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGC
GTATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAG
GCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATT
CACGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGG
ACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGG
CGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAG
CTCTGAAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTATTTGATATTTGAAATTCTTCTGTA
AGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAAATTGTCCTAGCTTACCCTAAATTT
CAAATCTGAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTT
TCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATCGTT
ACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATT
AAACTGCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCTAAGTTGAAAAATAAAAGGTTGTCA
ATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTAAGTGGCCTAACCTGTTTCTTGCCA
ATAAGTAGGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCA
CTACCTAAGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTTTCT

>In-frame_ENAH_ENST00000366843_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_1923nt
CGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGAGGTGGGA
GGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACACTCCCGGC
CGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAGCTGCTCC
CCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCACCATGAG
GGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTATCAAAT
CTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTCCTTTT
ATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGTATGTA
ACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGCAACTT
CTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCACGCTG
ACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGACCAGAG
GCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCGGGGTC
TTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCTCTGAA
GTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTATTTGATATTTGAAATTCTTCTGTAAGCCTGT
CTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAAATTGTCCTAGCTTACCCTAAATTTCAAATCT
GAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTTTCACGAA
TGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATCGTTACTGTCG
GGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATTAAACTGC
ACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCTAAGTTGAAAAATAAAAGGTTGTCAATCGAAT
GGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTAAGTGGCCTAACCTGTTTCTTGCCAATAAGTA
GGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCACTACCTA
AGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTTTCTTTTGTAA

>In-frame_ENAH_ENST00000284563_chr1_225840388_-_SCCPDH_ENST00000366510_chr1_246921528_+_1594nt
GGGGAAGCCTCTGCGCCGCCGGCACCATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAG
TAATTTGAGAAAACTAAGAAATGTATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTG
TCGGGAACTCAAAGGTTATTCCATTCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGA
GGAATCACCAGTTCAGTATGCTGCGTATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTT
CTTTGTGAGGTTTGGAATTGGAAGGCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACA
AAAACAGATTGATGCTGCCTCATTCACGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATAT
CAAAATTTGTACTCAGGTGAAAGGACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGA
TGCTTCTCATCTGCCTAAGGCGGGCGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGG
TATTGAGTTTAGTGTTATTAGCAGCTCTGAAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTA
TTTGATATTTGAAATTCTTCTGTAAGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAA
ATTGTCCTAGCTTACCCTAAATTTCAAATCTGAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTT
CATTGATGTGTTCCTGGTAGATTTTCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTC
ATCGGGGGTGCGCACACCATCGTTACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACAT
ACTGTCTTGAGCCTTTGCTAAATTAAACTGCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCT
AAGTTGAAAAATAAAAGGTTGTCAATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTA
AGTGGCCTAACCTGTTTCTTGCCAATAAGTAGGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAG
CTTATAAGTTGCTATCAATTTTCACTACCTAAGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCT


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FusionGenePPI for ENAH_SCCPDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ENAHABI1, RAPH1, XPO6, DNMBP, TES, ZYX, BAIAP2, PFN1, ELAVL1, TERF2IP, MAPK1, DYRK1B, HECW2, APBB1, SEPT7, COPS4, PPP6R3, TRIM28, WWOX, SMURF2, XIRP1, LGALS3BP, TP53, ABI2, ABI3, PRMT6, PARL, VASP, PVRL4, EVL, NTRK1, FGFR1OP, XPO1, PRPF4, TACC3, SNW1, CDC5L, ATOH1, RAC1, YAP1, GPHN, PPM1K, TPTE, PFN2, TMOD3, BCHE, DCAF7, TRIM25SCCPDHPAXIP1, PEX19, HAUS7, SLC39A4, DNAJB11, TMEM160, PDE4DIP, RPN1, ZZEF1, RAB4A, USP13, SQSTM1, PAIP2, HECTD3, MIEN1, SAAL1, WAPAL, TAF1, KBTBD7, DDB2, ACTR1B, FAM63B, BZW1, CPT2, GLRX, MDH1, PGM1, NTRK1, COQ9, NDUFA4, TMEM258, MTMR14, PPP6R2, BZW2, C3AR1, CPLX2, C12orf49, RAB6B, SCGB2A2, MED21, DPAGT1, ENSA, ATP6V0D1, FEZ1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENAH_SCCPDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENAH_SCCPDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENAHC0023467Leukemia, Myelocytic, Acute1CTD_human