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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11586

FusionGeneSummary for ENAH_ENAH

check button Fusion gene summary
Fusion gene informationFusion gene name: ENAH_ENAH
Fusion gene ID: 11586
HgeneTgene
Gene symbol

ENAH

ENAH

Gene ID

55740

55740

Gene nameENAH, actin regulatorENAH, actin regulator
SynonymsENA|MENA|NDPP1ENA|MENA|NDPP1
Cytomap

1q42.12

1q42.12

Type of geneprotein-codingprotein-coding
Descriptionprotein enabled homologenabled homologmammalian enabled variant 11amammalian enabled variant panprotein enabled homologenabled homologmammalian enabled variant 11amammalian enabled variant pan
Modification date2018052020180520
UniProtAcc

Q8N8S7

Q8N8S7

Ensembl transtripts involved in fusion geneENST00000366844, ENST00000366843, 
ENST00000284563, ENST00000391874, 
ENST00000366844, ENST00000366843, 
ENST00000284563, ENST00000391874, 
Fusion gene scores* DoF score7 X 7 X 5=2451 X 4 X 1=4
# samples 104
** MAII scorelog2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/4*10)=3.32192809488736
Context

PubMed: ENAH [Title/Abstract] AND ENAH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF802940ENAHchr1

225706900

-ENAHchr1

225755117

-
ChiTaRS3.1BM476111ENAHchr1

225677631

-ENAHchr1

225678899

-
ChiTaRS3.1BM874481ENAHchr1

225685223

+ENAHchr1

225681436

+
ChiTaRS3.1BM800638ENAHchr1

225683723

+ENAHchr1

225684413

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000366844ENST00000366844ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000366844ENST00000366843ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000366844ENST00000284563ENAHchr1

225706900

-ENAHchr1

225755117

-
5CDS-5UTRENST00000366844ENST00000391874ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000366843ENST00000366844ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000366843ENST00000366843ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000366843ENST00000284563ENAHchr1

225706900

-ENAHchr1

225755117

-
5CDS-5UTRENST00000366843ENST00000391874ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000284563ENST00000366844ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000284563ENST00000366843ENAHchr1

225706900

-ENAHchr1

225755117

-
Frame-shiftENST00000284563ENST00000284563ENAHchr1

225706900

-ENAHchr1

225755117

-
5CDS-5UTRENST00000284563ENST00000391874ENAHchr1

225706900

-ENAHchr1

225755117

-
In-frameENST00000391874ENST00000366844ENAHchr1

225706900

-ENAHchr1

225755117

-
In-frameENST00000391874ENST00000366843ENAHchr1

225706900

-ENAHchr1

225755117

-
In-frameENST00000391874ENST00000284563ENAHchr1

225706900

-ENAHchr1

225755117

-
5CDS-5UTRENST00000391874ENST00000391874ENAHchr1

225706900

-ENAHchr1

225755117

-
intron-3UTRENST00000366844ENST00000366844ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366844ENST00000366843ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366844ENST00000284563ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366844ENST00000391874ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-3UTRENST00000366843ENST00000366844ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366843ENST00000366843ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366843ENST00000284563ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000366843ENST00000391874ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-3UTRENST00000284563ENST00000366844ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000284563ENST00000366843ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000284563ENST00000284563ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000284563ENST00000391874ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-3UTRENST00000391874ENST00000366844ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000391874ENST00000366843ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000391874ENST00000284563ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-intronENST00000391874ENST00000391874ENAHchr1

225677631

-ENAHchr1

225678899

-
intron-3UTRENST00000366844ENST00000366844ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366844ENST00000366843ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366844ENST00000284563ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366844ENST00000391874ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-3UTRENST00000366843ENST00000366844ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366843ENST00000366843ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366843ENST00000284563ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000366843ENST00000391874ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-3UTRENST00000284563ENST00000366844ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000284563ENST00000366843ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000284563ENST00000284563ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000284563ENST00000391874ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-3UTRENST00000391874ENST00000366844ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000391874ENST00000366843ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000391874ENST00000284563ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-intronENST00000391874ENST00000391874ENAHchr1

225685223

+ENAHchr1

225681436

+
intron-3UTRENST00000366844ENST00000366844ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366844ENST00000366843ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366844ENST00000284563ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366844ENST00000391874ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-3UTRENST00000366843ENST00000366844ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366843ENST00000366843ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366843ENST00000284563ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000366843ENST00000391874ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-3UTRENST00000284563ENST00000366844ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000284563ENST00000366843ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000284563ENST00000284563ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000284563ENST00000391874ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-3UTRENST00000391874ENST00000366844ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000391874ENST00000366843ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000391874ENST00000284563ENAHchr1

225683723

+ENAHchr1

225684413

-
intron-intronENST00000391874ENST00000391874ENAHchr1

225683723

+ENAHchr1

225684413

-

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FusionProtFeatures for ENAH_ENAH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENAH

Q8N8S7

ENAH

Q8N8S7

Ena/VASP proteins are actin-associated proteins involvedin a range of processes dependent on cytoskeleton remodeling andcell polarity such as axon guidance and lamellipodial andfilopodial dynamics in migrating cells. ENAH induces the formationof F-actin rich outgrowths in fibroblasts. Acts synergisticallywith BAIAP2-alpha and downstream of NTN1 to promote filipodiaformation (By similarity). {ECO:0000250,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. Ena/VASP proteins are actin-associated proteins involvedin a range of processes dependent on cytoskeleton remodeling andcell polarity such as axon guidance and lamellipodial andfilopodial dynamics in migrating cells. ENAH induces the formationof F-actin rich outgrowths in fibroblasts. Acts synergisticallywith BAIAP2-alpha and downstream of NTN1 to promote filipodiaformation (By similarity). {ECO:0000250,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENAH_ENAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENAH_ENAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ENAHABI1, RAPH1, XPO6, DNMBP, TES, ZYX, BAIAP2, PFN1, ELAVL1, TERF2IP, MAPK1, DYRK1B, HECW2, APBB1, SEPT7, COPS4, PPP6R3, TRIM28, WWOX, SMURF2, XIRP1, LGALS3BP, TP53, ABI2, ABI3, PRMT6, PARL, VASP, PVRL4, EVL, NTRK1, FGFR1OP, XPO1, PRPF4, TACC3, SNW1, CDC5L, ATOH1, RAC1, YAP1, GPHN, PPM1K, TPTE, PFN2, TMOD3, BCHE, DCAF7, TRIM25ENAHABI1, RAPH1, XPO6, DNMBP, TES, ZYX, BAIAP2, PFN1, ELAVL1, TERF2IP, MAPK1, DYRK1B, HECW2, APBB1, SEPT7, COPS4, PPP6R3, TRIM28, WWOX, SMURF2, XIRP1, LGALS3BP, TP53, ABI2, ABI3, PRMT6, PARL, VASP, PVRL4, EVL, NTRK1, FGFR1OP, XPO1, PRPF4, TACC3, SNW1, CDC5L, ATOH1, RAC1, YAP1, GPHN, PPM1K, TPTE, PFN2, TMOD3, BCHE, DCAF7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENAH_ENAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ENAH_ENAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENAHC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneENAHC0023467Leukemia, Myelocytic, Acute1CTD_human