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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11569

FusionGeneSummary for EMP1_DNAJA2

check button Fusion gene summary
Fusion gene informationFusion gene name: EMP1_DNAJA2
Fusion gene ID: 11569
HgeneTgene
Gene symbol

EMP1

DNAJA2

Gene ID

2012

10294

Gene nameepithelial membrane protein 1DnaJ heat shock protein family (Hsp40) member A2
SynonymsCL-20|EMP-1|TMPCPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2
Cytomap

12p13.1

16q11.2

Type of geneprotein-codingprotein-coding
Descriptionepithelial membrane protein 1tumor-associated membrane proteindnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14
Modification date2018052320180523
UniProtAcc

P54849

O60884

Ensembl transtripts involved in fusion geneENST00000256951, ENST00000537612, 
ENST00000431267, ENST00000544053, 
ENST00000542289, ENST00000396301, 
ENST00000317089, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 4 X 3=48
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EMP1 [Title/Abstract] AND DNAJA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEMP1

GO:0008219

cell death

12107182

HgeneEMP1

GO:0032060

bleb assembly

12107182

TgeneDNAJA2

GO:0042026

protein refolding

21231916


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM785881EMP1chr12

13369379

+DNAJA2chr16

47002066

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000256951ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-
intron-3CDSENST00000537612ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-
intron-3CDSENST00000431267ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-
intron-3CDSENST00000544053ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-
intron-3CDSENST00000542289ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-
intron-3CDSENST00000396301ENST00000317089EMP1chr12

13369379

+DNAJA2chr16

47002066

-

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FusionProtFeatures for EMP1_DNAJA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EMP1

P54849

DNAJA2

O60884

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EMP1_DNAJA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EMP1_DNAJA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EMP1_DNAJA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EMP1_DNAJA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEMP1C0000786Spontaneous abortion1CTD_human
HgeneEMP1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneEMP1C0033578Prostatic Neoplasms1CTD_human
HgeneEMP1C0041696Unipolar Depression1PSYGENET
HgeneEMP1C1269683Major Depressive Disorder1PSYGENET