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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11564

FusionGeneSummary for EML4_HNRNPA1P57

check button Fusion gene summary
Fusion gene informationFusion gene name: EML4_HNRNPA1P57
Fusion gene ID: 11564
HgeneTgene
Gene symbol

EML4

HNRNPA1P57

Gene ID

27436

101060039

Gene nameechinoderm microtubule associated protein like 4heterogeneous nuclear ribonucleoprotein A1 pseudogene 57
SynonymsC2orf2|ELP120|EMAP-4|EMAPL4|ROPP120-
Cytomap

2p21

2p22.1

Type of geneprotein-codingpseudo
Descriptionechinoderm microtubule-associated protein-like 4restrictedly overexpressed proliferation-associated proteinropp 120-
Modification date2018052320180329
UniProtAcc

Q9HC35

Ensembl transtripts involved in fusion geneENST00000318522, ENST00000402711, 
ENST00000482660, ENST00000401738, 
ENST00000453191, 
ENST00000431359, 
Fusion gene scores* DoF score9 X 17 X 13=19891 X 1 X 1=1
# samples 271
** MAII scorelog2(27/1989*10)=-2.88101196378291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: EML4 [Title/Abstract] AND HNRNPA1P57 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-A5FT-01AEML4chr2

42396776

+HNRNPA1P57chr2

41383737

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000318522ENST00000431359EML4chr2

42396776

+HNRNPA1P57chr2

41383737

+
5CDS-3UTRENST00000402711ENST00000431359EML4chr2

42396776

+HNRNPA1P57chr2

41383737

+
3UTR-3UTRENST00000482660ENST00000431359EML4chr2

42396776

+HNRNPA1P57chr2

41383737

+
5CDS-3UTRENST00000401738ENST00000431359EML4chr2

42396776

+HNRNPA1P57chr2

41383737

+
intron-3UTRENST00000453191ENST00000431359EML4chr2

42396776

+HNRNPA1P57chr2

41383737

+

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FusionProtFeatures for EML4_HNRNPA1P57


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML4

Q9HC35

HNRNPA1P57

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EML4_HNRNPA1P57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EML4_HNRNPA1P57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EML4NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7HNRNPA1P57


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EML4_HNRNPA1P57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EML4_HNRNPA1P57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
HgeneEML4C0027627Neoplasm Metastasis2CTD_human
HgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneEML4C0006118Brain Neoplasms1CTD_human