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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 1155

FusionGeneSummary for AGPS_PDE11A

check button Fusion gene summary
Fusion gene informationFusion gene name: AGPS_PDE11A
Fusion gene ID: 1155
HgeneTgene
Gene symbol

AGPS

PDE11A

Gene ID

8540

50940

Gene namealkylglycerone phosphate synthasephosphodiesterase 11A
SynonymsADAP-S|ADAS|ADHAPS|ADPS|ALDHPSY|RCDP3PPNAD2
Cytomap

2q31.2

2q31.2

Type of geneprotein-codingprotein-coding
Descriptionalkyldihydroxyacetonephosphate synthase, peroxisomalaging-associated gene 5 proteinaging-associated protein 5alkyl-DHAP synthasedual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A
Modification date2018052220180329
UniProtAcc

O00116

Q9HCR9

Ensembl transtripts involved in fusion geneENST00000264167, ENST00000409888, 
ENST00000286063, ENST00000358450, 
ENST00000450799, ENST00000409504, 
ENST00000389683, ENST00000449286, 
ENST00000497003, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 4 X 6=192
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGPS [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGPS

GO:0008610

lipid biosynthetic process

9553082


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-FV-A496-01AAGPSchr2

178299145

+PDE11Achr2

178576606

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264167ENST00000286063AGPSchr2

178299145

+PDE11Achr2

178576606

-
In-frameENST00000264167ENST00000358450AGPSchr2

178299145

+PDE11Achr2

178576606

-
5CDS-intronENST00000264167ENST00000450799AGPSchr2

178299145

+PDE11Achr2

178576606

-
5CDS-intronENST00000264167ENST00000409504AGPSchr2

178299145

+PDE11Achr2

178576606

-
5CDS-intronENST00000264167ENST00000389683AGPSchr2

178299145

+PDE11Achr2

178576606

-
5CDS-intronENST00000264167ENST00000449286AGPSchr2

178299145

+PDE11Achr2

178576606

-
5CDS-5UTRENST00000264167ENST00000497003AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-3CDSENST00000409888ENST00000286063AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-3CDSENST00000409888ENST00000358450AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-intronENST00000409888ENST00000450799AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-intronENST00000409888ENST00000409504AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-intronENST00000409888ENST00000389683AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-intronENST00000409888ENST00000449286AGPSchr2

178299145

+PDE11Achr2

178576606

-
intron-5UTRENST00000409888ENST00000497003AGPSchr2

178299145

+PDE11Achr2

178576606

-

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FusionProtFeatures for AGPS_PDE11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGPS

O00116

PDE11A

Q9HCR9

Catalyzes the exchange of an acyl for a long-chain alkylgroup and the formation of the ether bond in the biosynthesis ofether phospholipids. {ECO:0000250}. Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides cAMP and cGMP.Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. {ECO:0000269|PubMed:10725373,ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+3202_8147659Compositional biasNote=Poly-Ala
TgenePDE11Achr2:178299145chr2:178576606ENST00000358450-1221588_912431684DomainPDEase
TgenePDE11Achr2:178299145chr2:178576606ENST00000389683-817402_558237490DomainNote=GAF 2
TgenePDE11Achr2:178299145chr2:178576606ENST00000389683-817588_912237490DomainPDEase
TgenePDE11Achr2:178299145chr2:178576606ENST00000409504-1020402_558323663DomainNote=GAF 2
TgenePDE11Achr2:178299145chr2:178576606ENST00000409504-1020588_912323663DomainPDEase
TgenePDE11Achr2:178299145chr2:178576606ENST00000449286-1019402_558323576DomainNote=GAF 2
TgenePDE11Achr2:178299145chr2:178576606ENST00000449286-1019588_912323576DomainPDEase

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320202_384147659DomainFAD-binding PCMH-type
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320234_240147659Nucleotide bindingFAD
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320303_309147659Nucleotide bindingFAD
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320316_319147659Nucleotide bindingFAD
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320368_374147659Nucleotide bindingFAD
HgeneAGPSchr2:178299145chr2:178576606ENST00000264167+320615_617147659RegionImportant for enzyme activity
TgenePDE11Achr2:178299145chr2:178576606ENST00000286063-1120217_370681934DomainNote=GAF 1
TgenePDE11Achr2:178299145chr2:178576606ENST00000286063-1120402_558681934DomainNote=GAF 2
TgenePDE11Achr2:178299145chr2:178576606ENST00000286063-1120588_912681934DomainPDEase
TgenePDE11Achr2:178299145chr2:178576606ENST00000358450-1221217_370431684DomainNote=GAF 1
TgenePDE11Achr2:178299145chr2:178576606ENST00000358450-1221402_558431684DomainNote=GAF 2
TgenePDE11Achr2:178299145chr2:178576606ENST00000389683-817217_370237490DomainNote=GAF 1
TgenePDE11Achr2:178299145chr2:178576606ENST00000409504-1020217_370323663DomainNote=GAF 1
TgenePDE11Achr2:178299145chr2:178576606ENST00000449286-1019217_370323576DomainNote=GAF 1


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FusionGeneSequence for AGPS_PDE11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_400aa
MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEV
MKWNGWGTNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNA
FQAKSGSALAQLTGTSATLEHHHFNHAVMILQSEGHNIFANLSSKETSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLTQALVKVNVKLKPM

>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_400aa
MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEV
MKWNGWGTNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNA
FQAKSGSALAQLTGTSATLEHHHFNHAVMILQSEGHNIFANLSSKETSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLTQALVKVNVKLKPM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_1200nt
ATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTGGCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGAC
CCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCTCTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCG
CGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCACGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTT
ATGAAATGGAATGGATGGGGATATAATGATTCTAAATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTT
AGTGGCATGGGTTTACCAACATTTAAAGAATGGATCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGG
TTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCC
TTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATC
CTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCA
ACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGT
GATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTA
ACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAA
CTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATG
CTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGT

>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_1200nt
ATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTGGCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGAC
CCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCTCTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCG
CGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCACGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTT
ATGAAATGGAATGGATGGGGATATAATGATTCTAAATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTT
AGTGGCATGGGTTTACCAACATTTAAAGAATGGATCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGG
TTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCC
TTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATC
CTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCA
ACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGT
GATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTA
ACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAA
CTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATG
CTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_7501nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAG
CGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAAC
TCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACC
TGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTG
AATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTG
ACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGA
GATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCA
TCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGG
AAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCT
CCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAG
ACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAA
GAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGAC
TGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTC
GTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCC
CAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAA
GGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGA
TGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAAT
GGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGA
CAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAAC
CAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTG
GGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTT
GCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATT
ATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCG
AACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTG
AATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGT
TTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTT
TTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAA
CCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTT
TGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGA
AAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAG
AAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTA
AGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGAC
CGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCT
AACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGG
CTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAG
ACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAA
ACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAA
ACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGA
GGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACT
GGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAA
GCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGA
GTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTT
TATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAG
CCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGC
AGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTC
CACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGG
AGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATT
TCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAG
CAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCT
TTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCC
CAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGT
TTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCT
TACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTG
CCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCC
ATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTT
TCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTA
GATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGAT
ATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAA
CTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAA
AGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTA
GAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATATCACACATATCCCATAAAT
GGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGC
ATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATT
AATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCC
CAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCA
GTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGA
AAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCA
CTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAAT
GTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATA
GAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGT
CATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCAC
TGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGT
AATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAAT
CTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTG
AGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAA
TTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGT
TTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAATCCATAGTTTTGGAAGCCCGCTTTAAGAGACCTGAA

>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_2684nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAG
CGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAAC
TCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACC
TGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTG
AATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTG
ACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGA
GATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCA
TCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGG
AAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCT
CCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAG
ACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAA
GAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGAC
TGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTC
GTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCC
CAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAA
GGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGA
TGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAAT
GGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGA
CAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAAC
CAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTG
GGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTT
GCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATT
ATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCG


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FusionGenePPI for AGPS_PDE11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGPSGNPAT, ATG16L1, ABCD3, ABCD1, IDH3G, LGALS3, SCP2, CSRP2, PEX5, PEX14, HDAC11, PARK2, MDM2, GORASP1, CCDC8, MRPL37, TMEM87A, LMAN1, NTRK1, EMC2, CHORDC1, PARD6B, MCM2, NCDN, PDHA1PDE11A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGPS_PDE11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDE11AQ9HCR9DB00820TadalafilDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11Asmall moleculeapproved|investigational

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RelatedDiseases for AGPS_PDE11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGPSC1838612Rhizomelic chondrodysplasia punctata, type 33CTD_human;ORPHANET;UNIPROT
TgenePDE11AC0041696Unipolar Depression1PSYGENET
TgenePDE11AC1269683Major Depressive Disorder1PSYGENET