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Fusion gene ID: 1155 |
FusionGeneSummary for AGPS_PDE11A |
Fusion gene summary |
Fusion gene information | Fusion gene name: AGPS_PDE11A | Fusion gene ID: 1155 | Hgene | Tgene | Gene symbol | AGPS | PDE11A | Gene ID | 8540 | 50940 |
Gene name | alkylglycerone phosphate synthase | phosphodiesterase 11A | |
Synonyms | ADAP-S|ADAS|ADHAPS|ADPS|ALDHPSY|RCDP3 | PPNAD2 | |
Cytomap | 2q31.2 | 2q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | alkyldihydroxyacetonephosphate synthase, peroxisomalaging-associated gene 5 proteinaging-associated protein 5alkyl-DHAP synthase | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A | |
Modification date | 20180522 | 20180329 | |
UniProtAcc | O00116 | Q9HCR9 | |
Ensembl transtripts involved in fusion gene | ENST00000264167, ENST00000409888, | ENST00000286063, ENST00000358450, ENST00000450799, ENST00000409504, ENST00000389683, ENST00000449286, ENST00000497003, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 4 X 6=192 |
# samples | 3 | 8 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AGPS [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AGPS | GO:0008610 | lipid biosynthetic process | 9553082 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-FV-A496-01A | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000264167 | ENST00000286063 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
In-frame | ENST00000264167 | ENST00000358450 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
5CDS-intron | ENST00000264167 | ENST00000450799 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
5CDS-intron | ENST00000264167 | ENST00000409504 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
5CDS-intron | ENST00000264167 | ENST00000389683 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
5CDS-intron | ENST00000264167 | ENST00000449286 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
5CDS-5UTR | ENST00000264167 | ENST00000497003 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-3CDS | ENST00000409888 | ENST00000286063 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-3CDS | ENST00000409888 | ENST00000358450 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-intron | ENST00000409888 | ENST00000450799 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-intron | ENST00000409888 | ENST00000409504 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-intron | ENST00000409888 | ENST00000389683 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-intron | ENST00000409888 | ENST00000449286 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
intron-5UTR | ENST00000409888 | ENST00000497003 | AGPS | chr2 | 178299145 | + | PDE11A | chr2 | 178576606 | - |
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FusionProtFeatures for AGPS_PDE11A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AGPS | PDE11A |
Catalyzes the exchange of an acyl for a long-chain alkylgroup and the formation of the ether bond in the biosynthesis ofether phospholipids. {ECO:0000250}. | Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides cAMP and cGMP.Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. {ECO:0000269|PubMed:10725373,ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 2_8 | 147 | 659 | Compositional bias | Note=Poly-Ala |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000358450 | - | 12 | 21 | 588_912 | 431 | 684 | Domain | PDEase |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000389683 | - | 8 | 17 | 402_558 | 237 | 490 | Domain | Note=GAF 2 |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000389683 | - | 8 | 17 | 588_912 | 237 | 490 | Domain | PDEase |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000409504 | - | 10 | 20 | 402_558 | 323 | 663 | Domain | Note=GAF 2 |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000409504 | - | 10 | 20 | 588_912 | 323 | 663 | Domain | PDEase |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000449286 | - | 10 | 19 | 402_558 | 323 | 576 | Domain | Note=GAF 2 |
Tgene | >PDE11A | chr2:178299145 | chr2:178576606 | ENST00000449286 | - | 10 | 19 | 588_912 | 323 | 576 | Domain | PDEase |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 202_384 | 147 | 659 | Domain | FAD-binding PCMH-type |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 234_240 | 147 | 659 | Nucleotide binding | FAD |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 303_309 | 147 | 659 | Nucleotide binding | FAD |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 316_319 | 147 | 659 | Nucleotide binding | FAD |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 368_374 | 147 | 659 | Nucleotide binding | FAD |
Hgene | >AGPS | chr2:178299145 | chr2:178576606 | ENST00000264167 | + | 3 | 20 | 615_617 | 147 | 659 | Region | Important for enzyme activity |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000286063 | - | 11 | 20 | 217_370 | 681 | 934 | Domain | Note=GAF 1 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000286063 | - | 11 | 20 | 402_558 | 681 | 934 | Domain | Note=GAF 2 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000286063 | - | 11 | 20 | 588_912 | 681 | 934 | Domain | PDEase |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000358450 | - | 12 | 21 | 217_370 | 431 | 684 | Domain | Note=GAF 1 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000358450 | - | 12 | 21 | 402_558 | 431 | 684 | Domain | Note=GAF 2 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000389683 | - | 8 | 17 | 217_370 | 237 | 490 | Domain | Note=GAF 1 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000409504 | - | 10 | 20 | 217_370 | 323 | 663 | Domain | Note=GAF 1 |
Tgene | PDE11A | chr2:178299145 | chr2:178576606 | ENST00000449286 | - | 10 | 19 | 217_370 | 323 | 576 | Domain | Note=GAF 1 |
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FusionGeneSequence for AGPS_PDE11A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_400aa MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEV MKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNA FQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPM >In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_400aa MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEV MKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNA FQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPM |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_1200nt ATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTGGCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGAC CCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCTCTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCG CGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCACGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTT ATGAAATGGAATGGATGGGGATATAATGATTCTAAATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTT AGTGGCATGGGTTTACCAACATTTAAAGAATGGATCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGG TTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCC TTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATC CTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCA ACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGT GATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTA ACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAA CTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATG CTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGT >In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_1200nt ATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTGGCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGAC CCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCTCTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCG CGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCACGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTT ATGAAATGGAATGGATGGGGATATAATGATTCTAAATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTT AGTGGCATGGGTTTACCAACATTTAAAGAATGGATCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGG TTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCC TTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATC CTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCA ACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGT GATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTA ACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAA CTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATG CTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000286063_chr2_178576606_-_7501nt GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAG CGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAAC TCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACC TGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTG AATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTG ACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGA GATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCA TCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGG AAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCT CCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAG ACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAA GAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGAC TGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTC GTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCC CAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAA GGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGA TGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAAT GGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGA CAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAAC CAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTG GGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTT GCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATT ATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCG AACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTG AATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGT TTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTT TTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAA CCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTT TGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGA AAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAG AAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTA AGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGAC CGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCT AACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGG CTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAG ACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAA ACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAA ACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGA GGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACT GGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAA GCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGA GTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTT TATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAG CCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGC AGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTC CACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGG AGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATT TCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAG CAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCT TTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCC CAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGT TTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCT TACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTG CCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCC ATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTT TCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTA GATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGAT ATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAA CTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAA AGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTA GAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATATCACACATATCCCATAAAT GGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGC ATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATT AATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCC CAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCA GTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGA AAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCA CTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAAT GTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATA GAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGT CATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCAC TGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGT AATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAAT CTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTG AGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAA TTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGT TTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAATCCATAGTTTTGGAAGCCCGCTTTAAGAGACCTGAA >In-frame_AGPS_ENST00000264167_chr2_178299145_+_PDE11A_ENST00000358450_chr2_178576606_-_2684nt GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAG CGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAAC TCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACC TGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTG AATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTG ACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGA GATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCA TCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGG AAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCT CCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAG ACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAA GAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGAC TGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTC GTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCC CAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAA GGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGA TGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAAT GGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGA CAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAAC CAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTG GGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTT GCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATT ATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCG |
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FusionGenePPI for AGPS_PDE11A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AGPS | GNPAT, ATG16L1, ABCD3, ABCD1, IDH3G, LGALS3, SCP2, CSRP2, PEX5, PEX14, HDAC11, PARK2, MDM2, GORASP1, CCDC8, MRPL37, TMEM87A, LMAN1, NTRK1, EMC2, CHORDC1, PARD6B, MCM2, NCDN, PDHA1 | PDE11A |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGPS_PDE11A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PDE11A | Q9HCR9 | DB00820 | Tadalafil | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | small molecule | approved|investigational |
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RelatedDiseases for AGPS_PDE11A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AGPS | C1838612 | Rhizomelic chondrodysplasia punctata, type 3 | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | PDE11A | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | PDE11A | C1269683 | Major Depressive Disorder | 1 | PSYGENET |