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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 11529

FusionGeneSummary for EME1_ERBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: EME1_ERBB2
Fusion gene ID: 11529
HgeneTgene
Gene symbol

EME1

ERBB2

Gene ID

146956

2064

Gene nameessential meiotic structure-specific endonuclease 1erb-b2 receptor tyrosine kinase 2
SynonymsMMS4L|SLX2ACD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1
Cytomap

17q21.33

17q12

Type of geneprotein-codingprotein-coding
Descriptioncrossover junction endonuclease EME1MMS4 homologSLX2 structure-specific endonuclease subunit homolog Aessential meiotic endonuclease 1 homolog 1essential meiotic endonuclease 1 homolog 2hMMS4homolog of yeast EME1 endonucleasereceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
Modification date2018052320180527
UniProtAcc

Q96AY2

P04626

Ensembl transtripts involved in fusion geneENST00000393271, ENST00000338165, 
ENST00000511648, 
ENST00000584601, 
ENST00000406381, ENST00000541774, 
ENST00000445658, ENST00000540147, 
ENST00000584450, ENST00000269571, 
ENST00000578199, ENST00000540042, 
ENST00000584888, 
Fusion gene scores* DoF score1 X 1 X 1=117 X 14 X 7=1666
# samples 118
** MAII scorelog2(1/1*10)=3.32192809488736log2(18/1666*10)=-3.21031958903587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EME1 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERBB2

GO:0007165

signal transduction

10572067

TgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

TgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

TgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

TgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

TgeneERBB2

GO:0042060

wound healing

12646923

TgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

TgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

TgeneERBB2

GO:0045945

positive regulation of transcription by RNA polymerase III

19372587

TgeneERBB2

GO:0046777

protein autophosphorylation

7556068

TgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

TgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

TgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1F2-01AEME1chr17

48452873

+ERBB2chr17

37882815

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393271ENST00000584601EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000406381EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000541774EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000445658EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000540147EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000584450EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000393271ENST00000269571EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000393271ENST00000578199EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000393271ENST00000540042EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000393271ENST00000584888EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000584601EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000406381EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000541774EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000445658EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000540147EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000584450EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000338165ENST00000269571EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000338165ENST00000578199EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000338165ENST00000540042EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000338165ENST00000584888EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000584601EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000406381EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000541774EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000445658EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000540147EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000584450EME1chr17

48452873

+ERBB2chr17

37882815

+
In-frameENST00000511648ENST00000269571EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000511648ENST00000578199EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000511648ENST00000540042EME1chr17

48452873

+ERBB2chr17

37882815

+
5CDS-intronENST00000511648ENST00000584888EME1chr17

48452873

+ERBB2chr17

37882815

+

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FusionProtFeatures for EME1_ERBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EME1

Q96AY2

ERBB2

P04626

Interacts with MUS81 to form a DNA structure-specificendonuclease with substrate preference for branched DNA structureswith a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions.May be required in mitosis for the processing of stalled orcollapsed replication forks. {ECO:0000269|PubMed:12686547,ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801,ECO:0000269|PubMed:17289582}. Protein tyrosine kinase that is part of several cellsurface receptor complexes, but that apparently needs a coreceptorfor ligand binding. Essential component of a neuregulin-receptorcomplex, although neuregulins do not interact with it alone. GP30is a potential ligand for this receptor. Regulates outgrowth andstabilization of peripheral microtubules (MTs). Upon ERBB2activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits thephosphorylation and thus the inhibition of GSK3B at cell membrane.This prevents the phosphorylation of APC and CLASP2, allowing itsassociation with the cell membrane. In turn, membrane-bound APCallows the localization of MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization. {ECO:0000305}. In the nucleus is involved in transcriptionalregulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicatedin transcriptional activation of CDKN1A; the function involvesSTAT3 and SRC. Involved in the transcription of rRNA genes by RNAPol I and enhances protein synthesis and cell growth.{ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516,ECO:0000269|PubMed:21555369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+2227720_9879571256DomainProtein kinase
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+2227720_9879421241DomainProtein kinase
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+2227676_6899571256MotifNote=Nuclear localization signal
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+2227676_6899421241MotifNote=Nuclear localization signal
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+2227726_7349571256Nucleotide bindingATP
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+2227726_7349421241Nucleotide bindingATP
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+222723_6529571256Topological domainExtracellular
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+2227676_12559571256Topological domainCytoplasmic
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+222723_6529421241Topological domainExtracellular
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+2227676_12559421241Topological domainCytoplasmic
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+2227653_6759571256TransmembraneHelical
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+2227653_6759421241TransmembraneHelical


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FusionGeneSequence for EME1_ERBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_357aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_357aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_357aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_557aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDE
EEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRF
RELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEETLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDL
TLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPETVNQPDVRPQP
PSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLTYWDQDPPERGAPPSTFKG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1071nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1071nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1071nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_1671nt
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGAAGGAACCA
TCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTGAAGATGAA
GAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACC
CCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCA
CACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTC
CGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCC
TTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGC
TTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTG
ACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGAC
CTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCC
CCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGG
GTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCT
CCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_2086nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1804nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1516nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAATATGTGAA
CCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAA
GACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGG
AGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGG

>In-frame_EME1_ENST00000393271_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_2086nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1804nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1516nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAATATGTGAA
CCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAA
GACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGG
AGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGG

>In-frame_EME1_ENST00000338165_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_2387nt
ACAGGAGCAGCACTGCCGGCGGGGGCGGGTGCCAGGGACTTGGAGGTGGAGGGGACGCGGCGGTACTCTGGCGTGGAATTATTTGATAGC
ACATACTGATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTGCCAACATTTGCCTTTCTGAAGA
AGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGGGAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTC
CAGCACCAGAGTTATTTTCACCACCTGTCCCAGAAATAGCTGAAACTGTCACACAAACACAGCCAGTCAGGTTGCTAAGCAGTGAAAGTG
AAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTTACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCC
CAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCC
ATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTG
GCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAA
GAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTA
CCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGC
CAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAG
CCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCC
AGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTG
GGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTG
ATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCA
CAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGC
CCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGA
AGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGC
CCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCT
TCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGAT
GTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCC
AGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGG
GAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCT
GGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGT
CCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTT
TACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584601_chr17_37882815_+_1684nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC
TGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATC
AAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCC
AGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAG

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000406381_chr17_37882815_+_1985nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC
TGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATC
AAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCC
AGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAG
GGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGC
GGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAA
TGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCC
AGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAAC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000541774_chr17_37882815_+_1985nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC
TGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATC
AAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCC
AGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAG
GGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGC
GGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAA
TGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCC
AGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAAC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000445658_chr17_37882815_+_1402nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000540147_chr17_37882815_+_1985nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC
TGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATC
AAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCC
AGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAG
GGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGC
GGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAA
TGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCC
AGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAAC

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000584450_chr17_37882815_+_1114nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGG
CCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTT
TGCCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCC
AGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAA

>In-frame_EME1_ENST00000511648_chr17_48452873_+_ERBB2_ENST00000269571_chr17_37882815_+_1985nt
GTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAAAGTGTTTTGGATCATCAAAATAATGAAGGTGCAT
CATGTGACTGGAAAAAGCCCTTTCCAAAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGACCTGA
TCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGCAGCAGCTTGGCAGTAACCAAAACAAATTCTGACA
TCCTTCCACCCCAGAAGAAAACCAAGCCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCGGCAGCAGAGACAAGCAAGGCAGA
AGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATGAAAGCCCAGAGGCCAGAGGAATGCTTAAAACACA
TCATTGTAGTGCTGGATCCAGGTTGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCA
GGGACCCCCAGCGCTTTGTGGTCATCCAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCACTGCTGGAGG
ACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGG
GCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCC
CCAGGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCC
TCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTGCCCTCTGAGACTGATGGCTACGTTGCCCCCC
TGACCTGCAGCCCCCAGCCTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCC
GACCTGCTGGTGCCACTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGGTGCCG
TGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGACAACCTCT
ATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTC
TGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATC
AAGAGGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCC
AGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAG
GGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGC
GGCCCTAAGGGAGTGTCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAACAGCAA
TGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATAAAGACCC
AGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAAC


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FusionGenePPI for EME1_ERBB2


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EME1MUS81, SLX4, SLX1B, SLX1A, APP, SUMO2, RBM33, KLK5, UHRF1, HIST1H2BG, HERC2, HNRNPU, PML, SORT1, YEATS4, CCDC88A, UGGT1, VWA9, KIF18A, PARD6B, CNTROB, USF1, CCL22, SNX21, INTU, NEUROG3, IDO2, DDB1ERBB2SHC1, SH3BGRL, PTPN11, GRB2, MUC1, CTNNB1, ERBB2, CD82, EGF, PAK1, ERBB2IP, PICK1, PIK3R2, DLG4, ERBB4, NRG1, JUP, STAT3, SRC, JAK2, HSP90B1, CD44, GRB7, PLCG1, IL6ST, OSMR, PTK2B, HSP90AA1, ELF3, EGFR, ERBB3, HDAC6, LRIG1, STUB1, HSPA4, IGF1R, CUL5, ESR1, PPP1R13B, H2AFY, PIK3R1, PIN1, PTK6, ACTB, POLR1B, KPNB1, XPO1, CLTC, AP2B1, EEA1, APBB1, SH2B2, IRS4, SH2D1B, SOCS1, NCK2, DAB1, GRAP2, APBB3, ABL1, FGR, CHN1, FER, PLCG2, RASA1, JAK1, IRS1, STAT1, MATK, TEC, TXK, ABL2, SYK, CRK, CRKL, BLK, BMX, VAV2, SH3BP2, SHC2, ITK, SLA, MAPK8IP2, RIN1, BCAR3, TENC1, TNS3, DOK6, SH2D5, SUPT6H, ANKS1B, CLNK, DOK4, BLNK, RIN2, SHC3, PIK3R3, ANKS1A, VAV1, DOK1, SH2D3A, SLA2, SH2D2A, CISH, VAV3, MAPK8IP1, SH2B3, TLN1, SRPK1, CBL, ERRFI1, FRS3, USP2, NXF1, DTWD2, TGFBR2, NAALADL2, LPAR6, VSIG4, PTGER3, CYP17A1, GLCE, IL13RA2, KLK5, LYPD3, NAT2, PRDM14, PSMC3IP, RHOBTB2, THRSP, ANXA6, BAI1, CLCN6, GMPR2, HDLBP, IARS, MTCH1, MUCL1, PHF23, POLD2, PSAP, STK24, TCEAL2, ATP6AP1, TTC9B, UTP18, ATP1A1, EEF1G, TNPO1, PC, SURF4, TFRC, VAPB, PTDSS1, HPSE, ZNF280C, CCDC88A, ZNF622, BTC, PTK2, TGFA, BCAR1, ESRRB, CDC37, EZR, RDX, ITGAV, L1CAM, ITGB1, CHEK2, TOP1, RRM2, CDK4, CDH2, CDH1, PTPN6, PTPRR, PTPRT, PTPRU, PTPRA, PTPRH, MPZL2, SSH1, CD79B, MAS1, HAVCR2, IL4R, PPM1A, PPM1F, ILKAP, DUSP14, DUSP18, DUSP19, STYX, GAB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneERBB2chr17:48452873chr17:37882815ENST00000269571+22271195_11979571256PIK3C2B
TgeneERBB2chr17:48452873chr17:37882815ENST00000541774+22271195_11979421241PIK3C2B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EME1_ERBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneERBB2P04626DB06366PertuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved
TgeneERBB2P04626DB08916AfatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved
TgeneERBB2P04626DB00072TrastuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational
TgeneERBB2P04626DB01259LapatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved|investigational
TgeneERBB2P04626DB05773Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational

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RelatedDiseases for EME1_ERBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneERBB2C1458155Mammary Neoplasms40CTD_human
TgeneERBB2C0033578Prostatic Neoplasms3CTD_human
TgeneERBB2C0038356Stomach Neoplasms3CTD_human
TgeneERBB2C0001418Adenocarcinoma2CTD_human
TgeneERBB2C0024668Mammary Neoplasms, Experimental2CTD_human
TgeneERBB2C0919267ovarian neoplasm2CTD_human
TgeneERBB2C0007117Basal cell carcinoma1CTD_human
TgeneERBB2C0007134Renal Cell Carcinoma1CTD_human
TgeneERBB2C0009375Colonic Neoplasms1CTD_human
TgeneERBB2C0014859Esophageal Neoplasms1CTD_human
TgeneERBB2C0016978gallbladder neoplasm1CTD_human
TgeneERBB2C0017185Gastrointestinal Neoplasms1CTD_human
TgeneERBB2C0024121Lung Neoplasms1CTD_human
TgeneERBB2C0024232Lymphatic Metastasis1CTD_human
TgeneERBB2C0024667Animal Mammary Neoplasms1CTD_human
TgeneERBB2C0025149Medulloblastoma1CTD_human
TgeneERBB2C0027627Neoplasm Metastasis1CTD_human
TgeneERBB2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneERBB2C0027659Neoplasms, Experimental1CTD_human
TgeneERBB2C0030354Papilloma1CTD_human
TgeneERBB2C0206698Cholangiocarcinoma1CTD_human
TgeneERBB2C0596263Carcinogenesis1CTD_human
TgeneERBB2C2931822Nasopharyngeal carcinoma1CTD_human