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Fusion gene ID: 1152 |
FusionGeneSummary for AGPAT6_ADAM9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGPAT6_ADAM9 | Fusion gene ID: 1152 | Hgene | Tgene | Gene symbol | AGPAT6 | ADAM9 | Gene ID | 137964 | 8754 |
| Gene name | glycerol-3-phosphate acyltransferase 4 | ADAM metallopeptidase domain 9 | |
| Synonyms | 1-AGPAT 6|AGPAT6|LPAAT-zeta|LPAATZ|TSARG7 | CORD9|MCMP|MDC9|Mltng | |
| Cytomap | 8p11.21 | 8p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycerol-3-phosphate acyltransferase 41-AGP acyltransferase 61-acyl-sn-glycerol-3-phosphate acyltransferase zeta1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)glycerol-3-phosphate acyltransferase 6lysophos | disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q13443 | ||
| Ensembl transtripts involved in fusion gene | ENST00000520258, ENST00000396987, | ENST00000487273, ENST00000466936, ENST00000481513, ENST00000484143, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 6=288 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGPAT6 [Title/Abstract] AND ADAM9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AGPAT6 | GO:0006637 | acyl-CoA metabolic process | 18238778 |
| Hgene | AGPAT6 | GO:0006656 | phosphatidylcholine biosynthetic process | 18238778 |
| Hgene | AGPAT6 | GO:0019432 | triglyceride biosynthetic process | 18238778 |
| Tgene | ADAM9 | GO:0000186 | activation of MAPKK activity | 17704059 |
| Tgene | ADAM9 | GO:0006509 | membrane protein ectodomain proteolysis | 9920899 |
| Tgene | ADAM9 | GO:0034612 | response to tumor necrosis factor | 11831872 |
| Tgene | ADAM9 | GO:0050714 | positive regulation of protein secretion | 17704059 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5522-01A | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000520258 | ENST00000487273 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| intron-intron | ENST00000520258 | ENST00000466936 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| intron-intron | ENST00000520258 | ENST00000481513 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| intron-intron | ENST00000520258 | ENST00000484143 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| Frame-shift | ENST00000396987 | ENST00000487273 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| 5CDS-intron | ENST00000396987 | ENST00000466936 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| 5CDS-intron | ENST00000396987 | ENST00000481513 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
| 5CDS-intron | ENST00000396987 | ENST00000484143 | AGPAT6 | chr8 | 41456823 | + | ADAM9 | chr8 | 38899465 | + |
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FusionProtFeatures for AGPAT6_ADAM9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGPAT6 | ADAM9 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Cleaves and releases a number of molecules withimportant roles in tumorigenesis and angiogenesis, such as TEK,KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells viainteractions with integrins. {ECO:0000250|UniProtKB:Q61072}. Isoform 2: May act as alpha-secretase for amyloidprecursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AGPAT6_ADAM9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AGPAT6_ADAM9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AGPAT6 | GFI1B, HSD17B7, MOV10, NXF1, TSPAN17, ERGIC3, TCTN2, TCTN3, TMEM17, TMEM216, EHD2, DFNA5, TRIM25, TES | ADAM9 | MAD2L2, SH3GL2, SNX9, PRKCD, CDH1, RNF2, CD1B, FIGF, TMEM25, PTPRK, GPHA2, CLPSL1, NUDC, KIF2C, ITGAV, ITGB5, SCGB1D4, ADAM32, LYZL2, INSL5, SLAMF1, LYZL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGPAT6_ADAM9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGPAT6_ADAM9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ADAM9 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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