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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11516

FusionGeneSummary for EMC10_EMC10

check button Fusion gene summary
Fusion gene informationFusion gene name: EMC10_EMC10
Fusion gene ID: 11516
HgeneTgene
Gene symbol

EMC10

EMC10

Gene ID

284361

284361

Gene nameER membrane protein complex subunit 10ER membrane protein complex subunit 10
SynonymsC19orf63|HSM1|HSS1C19orf63|HSM1|HSS1
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
DescriptionER membrane protein complex subunit 10UPF0510 protein INM02hematopoietic signal peptide-containing membrane domain-containing 1hematopoietic signal peptide-containing secreted 1ER membrane protein complex subunit 10UPF0510 protein INM02hematopoietic signal peptide-containing membrane domain-containing 1hematopoietic signal peptide-containing secreted 1
Modification date2018052320180523
UniProtAcc

Q5UCC4

Q5UCC4

Ensembl transtripts involved in fusion geneENST00000334976, ENST00000376918, 
ENST00000598585, 
ENST00000334976, 
ENST00000376918, ENST00000598585, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: EMC10 [Title/Abstract] AND EMC10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI038830EMC10chr19

50985504

-EMC10chr19

50986239

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334976ENST00000334976EMC10chr19

50985504

-EMC10chr19

50986239

-
5CDS-3UTRENST00000334976ENST00000376918EMC10chr19

50985504

-EMC10chr19

50986239

-
5CDS-3UTRENST00000334976ENST00000598585EMC10chr19

50985504

-EMC10chr19

50986239

-
3UTR-3UTRENST00000376918ENST00000334976EMC10chr19

50985504

-EMC10chr19

50986239

-
3UTR-3UTRENST00000376918ENST00000376918EMC10chr19

50985504

-EMC10chr19

50986239

-
3UTR-3UTRENST00000376918ENST00000598585EMC10chr19

50985504

-EMC10chr19

50986239

-
5CDS-3UTRENST00000598585ENST00000334976EMC10chr19

50985504

-EMC10chr19

50986239

-
5CDS-3UTRENST00000598585ENST00000376918EMC10chr19

50985504

-EMC10chr19

50986239

-
5CDS-3UTRENST00000598585ENST00000598585EMC10chr19

50985504

-EMC10chr19

50986239

-

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FusionProtFeatures for EMC10_EMC10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EMC10

Q5UCC4

EMC10

Q5UCC4

Promotes angiogenesis and tissue repair in the heartafter myocardial infarction. Stimulates cardiac endothelial cellmigration and outgrowth via the activation of p38 MAPK, PAK andMAPK2 signaling pathways. {ECO:0000269|PubMed:28931551}. Promotes angiogenesis and tissue repair in the heartafter myocardial infarction. Stimulates cardiac endothelial cellmigration and outgrowth via the activation of p38 MAPK, PAK andMAPK2 signaling pathways. {ECO:0000269|PubMed:28931551}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EMC10_EMC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EMC10_EMC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EMC10_EMC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EMC10_EMC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource