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Fusion gene ID: 11510 |
FusionGeneSummary for ELP5_PLA2G2A |
Fusion gene summary |
Fusion gene information | Fusion gene name: ELP5_PLA2G2A | Fusion gene ID: 11510 | Hgene | Tgene | Gene symbol | ELP5 | PLA2G2A | Gene ID | 23587 | 5320 |
Gene name | elongator acetyltransferase complex subunit 5 | phospholipase A2 group IIA | |
Synonyms | C17orf81|DERP6|HSPC002|MST071|MSTP071 | MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2 | |
Cytomap | 17p13.1 | 1p36.13 | |
Type of gene | protein-coding | protein-coding | |
Description | elongator complex protein 5S-phase 2 proteindermal papilla derived protein 6 | phospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid) | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TE02 | P14555 | |
Ensembl transtripts involved in fusion gene | ENST00000354429, ENST00000574255, ENST00000356683, ENST00000396627, ENST00000574993, ENST00000396628, ENST00000573657, | ENST00000400520, ENST00000496748, ENST00000375111, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 3 X 5=90 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ELP5 [Title/Abstract] AND PLA2G2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLA2G2A | GO:0006644 | phospholipid metabolic process | 17069818 |
Tgene | PLA2G2A | GO:0046473 | phosphatidic acid metabolic process | 9032461 |
Tgene | PLA2G2A | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22837859 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG950573 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000354429 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-5UTR | ENST00000354429 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000354429 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-3UTR | ENST00000574255 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-5UTR | ENST00000574255 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-3UTR | ENST00000574255 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000356683 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-5UTR | ENST00000356683 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000356683 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000396627 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-5UTR | ENST00000396627 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000396627 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000574993 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-5UTR | ENST00000574993 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000574993 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000396628 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-5UTR | ENST00000396628 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
3UTR-3UTR | ENST00000396628 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-3UTR | ENST00000573657 | ENST00000400520 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-5UTR | ENST00000573657 | ENST00000496748 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
intron-3UTR | ENST00000573657 | ENST00000375111 | ELP5 | chr17 | 7163206 | + | PLA2G2A | chr1 | 20302146 | + |
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FusionProtFeatures for ELP5_PLA2G2A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ELP5 | PLA2G2A |
Acts as subunit of the RNA polymerase II elongatorcomplex, which is a histone acetyltransferase component of the RNApolymerase II (Pol II) holoenzyme and is involved intranscriptional elongation. Elongator may play a role in chromatinremodeling and is involved in acetylation of histones H3 andprobably H4. Involved in cell migration (By similarity). May beinvolved in TP53-mediated transcriptional regulation.{ECO:0000250, ECO:0000269|PubMed:16850183}. | Catalyzes the calcium-dependent hydrolysis of the 2-acylgroups in 3-sn-phosphoglycerides (PubMed:2925633). Thought toparticipate in the regulation of phospholipid metabolism inbiomembranes including eicosanoid biosynthesis. Independent of itscatalytic activity, acts as a ligand for integrins(PubMed:18635536, PubMed:25398877). Binds to and activatesintegrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1(PubMed:18635536, PubMed:25398877). Binds to a site (site 2) whichis distinct from the classical ligand-binding site (site 1) andinduces integrin conformational changes and enhanced ligandbinding to site 1 (PubMed:25398877). Induces cell proliferation inan integrin-dependent manner (PubMed:18635536).{ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877,ECO:0000269|PubMed:2925633}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ELP5_PLA2G2A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELP5_PLA2G2A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELP5_PLA2G2A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PLA2G2A | P14555 | DB00328 | Indomethacin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Tgene | PLA2G2A | P14555 | DB02325 | Isopropyl Alcohol | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Tgene | PLA2G2A | P14555 | DB04786 | Suramin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Tgene | PLA2G2A | P14555 | DB01381 | Ginkgo biloba | Phospholipase A2, membrane associated | small molecule | approved|investigational|nutraceutical |
Tgene | PLA2G2A | P14555 | DB00586 | Diclofenac | Phospholipase A2, membrane associated | small molecule | approved|vet_approved |
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RelatedDiseases for ELP5_PLA2G2A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PLA2G2A | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | PLA2G2A | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | PLA2G2A | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | PLA2G2A | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | PLA2G2A | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | PLA2G2A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | PLA2G2A | C0349218 | Recurrent depressive disorder, unspecified | 1 | PSYGENET |
Tgene | PLA2G2A | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |