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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11495

FusionGeneSummary for ELOVL5_SLC25A27

check button Fusion gene summary
Fusion gene informationFusion gene name: ELOVL5_SLC25A27
Fusion gene ID: 11495
HgeneTgene
Gene symbol

ELOVL5

SLC25A27

Gene ID

60481

9481

Gene nameELOVL fatty acid elongase 5solute carrier family 25 member 27
SynonymsHELO1|SCA38|dJ483K16.1UCP4
Cytomap

6p12.1

6p12.3

Type of geneprotein-codingprotein-coding
Descriptionelongation of very long chain fatty acids protein 53-keto acyl-CoA synthase ELOVL5ELOVL FA elongase 5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)fatty acid elongase 1homolog of yeast long chain polyunmitochondrial uncoupling protein 4UCP 4uncoupling protein 4
Modification date2018052320180523
UniProtAcc

Q9NYP7

O95847

Ensembl transtripts involved in fusion geneENST00000370918, ENST00000304434, 
ENST00000542638, ENST00000541407, 
ENST00000486973, ENST00000370913, 
ENST00000371347, ENST00000411689, 
ENST00000452689, ENST00000604908, 
Fusion gene scores* DoF score7 X 3 X 7=1472 X 2 X 2=8
# samples 82
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ELOVL5 [Title/Abstract] AND SLC25A27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELOVL5

GO:0034625

fatty acid elongation, monounsaturated fatty acid

20427700

HgeneELOVL5

GO:0034626

fatty acid elongation, polyunsaturated fatty acid

20427700|20937905

HgeneELOVL5

GO:0042761

very long-chain fatty acid biosynthetic process

20427700|20937905


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-4589-01AELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000370918ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370918ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370918ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370918ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000304434ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000304434ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000304434ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000304434ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
intron-intronENST00000542638ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
intron-intronENST00000542638ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
intron-intronENST00000542638ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
intron-intronENST00000542638ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000541407ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000541407ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000541407ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000541407ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000486973ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000486973ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000486973ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000486973ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370913ENST00000371347ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370913ENST00000411689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370913ENST00000452689ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+
5UTR-intronENST00000370913ENST00000604908ELOVL5chr6

53213615

-SLC25A27chr6

46649264

+

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FusionProtFeatures for ELOVL5_SLC25A27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELOVL5

Q9NYP7

SLC25A27

O95847

UCP are mitochondrial transporter proteins that createproton leaks across the inner mitochondrial membrane, thusuncoupling oxidative phosphorylation from ATP synthesis. As aresult, energy is dissipated in the form of heat. May play a rolein thermoregulatory heat production and metabolism in brain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELOVL5_SLC25A27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELOVL5_SLC25A27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELOVL5ELAVL1, CERS2, YIPF5, SUCO, DPEP1, APLNR, SLC7A1, SLC22A9, UBC, TIMM17A, ROMO1SLC25A27NIT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELOVL5_SLC25A27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELOVL5_SLC25A27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELOVL5C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneELOVL5C0036341Schizophrenia1PSYGENET
HgeneELOVL5C4014812SPINOCEREBELLAR ATAXIA 381ORPHANET;UNIPROT
TgeneSLC25A27C0036341Schizophrenia2PSYGENET