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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11493

FusionGeneSummary for ELOVL5_PFKFB3

check button Fusion gene summary
Fusion gene informationFusion gene name: ELOVL5_PFKFB3
Fusion gene ID: 11493
HgeneTgene
Gene symbol

ELOVL5

PFKFB3

Gene ID

60481

5209

Gene nameELOVL fatty acid elongase 56-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
SynonymsHELO1|SCA38|dJ483K16.1IPFK2|PFK2|iPFK-2
Cytomap

6p12.1

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionelongation of very long chain fatty acids protein 53-keto acyl-CoA synthase ELOVL5ELOVL FA elongase 5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)fatty acid elongase 1homolog of yeast long chain polyun6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 36-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase6PF-2-K/Fru-2,6-P2ase 36PF-2-K/Fru-2,6-P2ase brain/placenta-type isozymePFK/FBPase 3fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
Modification date2018052320180524
UniProtAcc

Q9NYP7

Q16875

Ensembl transtripts involved in fusion geneENST00000370918, ENST00000304434, 
ENST00000542638, ENST00000541407, 
ENST00000486973, ENST00000370913, 
ENST00000536985, ENST00000379789, 
ENST00000540253, ENST00000317350, 
ENST00000379785, ENST00000379782, 
ENST00000360521, ENST00000379775, 
Fusion gene scores* DoF score7 X 3 X 7=1476 X 5 X 3=90
# samples 87
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELOVL5 [Title/Abstract] AND PFKFB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELOVL5

GO:0034625

fatty acid elongation, monounsaturated fatty acid

20427700

HgeneELOVL5

GO:0034626

fatty acid elongation, polyunsaturated fatty acid

20427700|20937905

HgeneELOVL5

GO:0042761

very long-chain fatty acid biosynthetic process

20427700|20937905


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-UZ-A9PQ-01AELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000370918ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370918ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000304434ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
intron-3CDSENST00000542638ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000541407ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000486973ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000536985ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000379789ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000540253ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000317350ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000379785ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000379782ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000360521ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+
5UTR-3CDSENST00000370913ENST00000379775ELOVL5chr6

53213615

-PFKFB3chr10

6255586

+

Top

FusionProtFeatures for ELOVL5_PFKFB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELOVL5

Q9NYP7

PFKFB3

Q16875

Synthesis and degradation of fructose 2,6-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELOVL5_PFKFB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELOVL5_PFKFB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELOVL5ELAVL1, CERS2, YIPF5, SUCO, DPEP1, APLNR, SLC7A1, SLC22A9, UBC, TIMM17A, ROMO1PFKFB3CUL2, ELAVL1, ARRB1, ARRB2, EIF4A3, MAGOH, ASB12, EGFR, HIST1H3E, PFKFB4, PFKFB2, PES1, CLUH, CYLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ELOVL5_PFKFB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ELOVL5_PFKFB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELOVL5C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneELOVL5C0036341Schizophrenia1PSYGENET
HgeneELOVL5C4014812SPINOCEREBELLAR ATAXIA 381ORPHANET;UNIPROT
TgenePFKFB3C0005586Bipolar Disorder1PSYGENET
TgenePFKFB3C0011570Mental Depression1PSYGENET
TgenePFKFB3C0028754Obesity1CTD_human
TgenePFKFB3C0037274Dermatologic disorders1CTD_human
TgenePFKFB3C0041696Unipolar Depression1PSYGENET
TgenePFKFB3C0151744Myocardial Ischemia1CTD_human
TgenePFKFB3C0311375Arsenic Poisoning1CTD_human
TgenePFKFB3C0525045Mood Disorders1PSYGENET
TgenePFKFB3C1269683Major Depressive Disorder1PSYGENET