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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11480

FusionGeneSummary for ELN_RBBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ELN_RBBP4
Fusion gene ID: 11480
HgeneTgene
Gene symbol

ELN

RBBP4

Gene ID

100130933

5928

Gene namesmall integral membrane protein 6RB binding protein 4, chromatin remodeling factor
SynonymsC17orf110|ELNNURF55|RBAP48|lin-53
Cytomap

17q25.1

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionsmall integral membrane protein 6endoregulinhistone-binding protein RBBP4CAF-1 subunit CCAF-I 48 kDa subunitCAF-I p48MSI1 protein homologRBBP-4chromatin assembly factor 1 subunit Cchromatin assembly factor I p48 subunitchromatin assembly factor/CAF-1 p48 subunitnucleosome-remodeling factor
Modification date2018040220180522
UniProtAcc

P15502

Q09028

Ensembl transtripts involved in fusion geneENST00000445912, ENST00000252034, 
ENST00000358929, ENST00000320492, 
ENST00000414324, ENST00000380562, 
ENST00000380575, ENST00000380584, 
ENST00000458204, ENST00000357036, 
ENST00000429192, ENST00000380553, 
ENST00000380576, ENST00000320399, 
ENST00000466878, 		ENST00000414241, 
ENST00000373493, ENST00000524393, 
ENST00000544435, ENST00000373485, 
ENST00000458695, 
Fusion gene scores* DoF score8 X 6 X 3=1443 X 3 X 2=18
# samples 73
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ELN [Title/Abstract] AND RBBP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBBP4

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneRBBP4

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneRBBP4

GO:0006338

chromatin remodeling

14609955

TgeneRBBP4

GO:0031497

chromatin assembly

8858152


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB264407ELNchr7

73455580

+RBBP4chr1

33160535

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000445912ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000445912ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000445912ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000445912ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000445912ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000445912ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000252034ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000358929ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000320492ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000414324ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380562ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380575ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380584ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000458204ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000357036ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000429192ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380553ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000380576ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
5CDS-intronENST00000320399ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000414241ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000373493ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000524393ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000544435ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000373485ELNchr7

73455580

+RBBP4chr1

33160535

-
intron-intronENST00000466878ENST00000458695ELNchr7

73455580

+RBBP4chr1

33160535

-

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FusionProtFeatures for ELN_RBBP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELN

P15502

RBBP4

Q09028

Core histone-binding subunit that may target chromatinassembly factors, chromatin remodeling factors and histonedeacetylases to their histone substrates in a manner that isregulated by nucleosomal DNA. Component of several complexes whichregulate chromatin metabolism. These include the chromatinassembly factor 1 (CAF-1) complex, which is required for chromatinassembly following DNA replication and DNA repair; the corehistone deacetylase (HDAC) complex, which promotes histonedeacetylation and consequent transcriptional repression; thenucleosome remodeling and histone deacetylase complex (the NuRDcomplex), which promotes transcriptional repression by histonedeacetylation and nucleosome remodeling; the PRC2/EED-EZH2complex, which promotes repression of homeotic genes duringdevelopment; and the NURF (nucleosome remodeling factor) complex.{ECO:0000269|PubMed:10866654}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELN_RBBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELN_RBBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELN_RBBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneELNP15502DB00533RofecoxibElastinsmall moleculeapproved|investigational|withdrawn

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RelatedDiseases for ELN_RBBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELNC0003499Supravalvular aortic stenosis2CTD_human;HPO;ORPHANET
HgeneELNC0034069Pulmonary Fibrosis2CTD_human
HgeneELNC0010495Cutis Laxa1CTD_human;HPO
HgeneELNC0019284Diaphragmatic Hernia1CTD_human
HgeneELNC0020538Hypertensive disease1CTD_human
HgeneELNC0024117Chronic Obstructive Airway Disease1CTD_human
HgeneELNC0034067Pulmonary Emphysema1CTD_human;HPO
HgeneELNC0151744Myocardial Ischemia1CTD_human
HgeneELNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human