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Fusion gene ID: 11419 |
FusionGeneSummary for ELK4_SLC26A9 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ELK4_SLC26A9 | Fusion gene ID: 11419 | Hgene | Tgene | Gene symbol | ELK4 | SLC26A9 | Gene ID | 2005 | 115019 |
Gene name | ELK4, ETS transcription factor | solute carrier family 26 member 9 | |
Synonyms | SAP1 | - | |
Cytomap | 1q32.1 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ETS domain-containing protein Elk-4ELK4, ETS-domain protein (SRF accessory protein 1)SAP-1serum response factor accessory protein 1 | solute carrier family 26 member 9anion transporter/exchanger protein 9anion transporter/exchanger-9solute carrier family 26 (anion exchanger), member 9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P28324 | Q7LBE3 | |
Ensembl transtripts involved in fusion gene | ENST00000357992, ENST00000289703, ENST00000468523, | ENST00000340781, ENST00000367135, ENST00000367134, | |
Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 1 X 1 X 1=1 |
# samples | 5 | 2 | |
** MAII score | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/1*10)=4.32192809488736 | |
Context | PubMed: ELK4 [Title/Abstract] AND SLC26A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ELK4 | GO:0070932 | histone H3 deacetylation | 22722849 |
Tgene | SLC26A9 | GO:0006820 | anion transport | 11834742|17673510 |
Tgene | SLC26A9 | GO:0006821 | chloride transport | 15800055|17673510|18769029|20658517|22544634 |
Tgene | SLC26A9 | GO:0010628 | positive regulation of gene expression | 20658517 |
Tgene | SLC26A9 | GO:0015701 | bicarbonate transport | 15800055 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-8265-01B | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
TCGA | LD | PRAD | TCGA-HC-8265-01A | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000357992 | ENST00000340781 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5CDS-5UTR | ENST00000357992 | ENST00000367135 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5CDS-5UTR | ENST00000357992 | ENST00000367134 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5CDS-intron | ENST00000289703 | ENST00000340781 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5CDS-5UTR | ENST00000289703 | ENST00000367135 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5CDS-5UTR | ENST00000289703 | ENST00000367134 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5UTR-intron | ENST00000468523 | ENST00000340781 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5UTR-5UTR | ENST00000468523 | ENST00000367135 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
5UTR-5UTR | ENST00000468523 | ENST00000367134 | ELK4 | chr1 | 205592804 | - | SLC26A9 | chr1 | 205904966 | - |
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FusionProtFeatures for ELK4_SLC26A9 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ELK4 | SLC26A9 |
Involved in both transcriptional activation andrepression. Interaction with SIRT7 leads to recruitment andstabilization of SIRT7 at promoters, followed by deacetylation ofhistone H3 at 'Lys-18' (H3K18Ac) and subsequent transcriptionrepression. Forms a ternary complex with the serum response factor(SRF). Requires DNA-bound SRF for ternary complex formation andmakes extensive DNA contacts to the 5'side of SRF, but does notbind DNA autonomously. {ECO:0000269|PubMed:22722849}. | DIDS- and thiosulfate- sensitive anion exchangermediating chloride, sulfate and oxalate transport. Mediateschloride/bicarbonate exchange or chloride-independent bicarbonateextrusion thus assuring bicarbonate secretion. Inhibited byammonium and thiosulfate. {ECO:0000269|PubMed:11834742,ECO:0000269|PubMed:15800055}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ELK4_SLC26A9 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELK4_SLC26A9 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ELK4 | BRCA1, SRF, ELAVL1, MAPK8, MAPK3, BLM, MUS81, MAPK1, TRIM25, SIRT7 | SLC26A9 | ATP4A |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELK4_SLC26A9 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELK4_SLC26A9 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC26A9 | C0021843 | Intestinal Obstruction | 1 | CTD_human |
Tgene | SLC26A9 | C1859047 | CYSTIC FIBROSIS MODIFIER 1 | 1 | CTD_human |