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Fusion gene ID: 11412 |
FusionGeneSummary for ELK3_LIN7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ELK3_LIN7A | Fusion gene ID: 11412 | Hgene | Tgene | Gene symbol | ELK3 | LIN7A | Gene ID | 2004 | 8825 |
| Gene name | ELK3, ETS transcription factor | lin-7 homolog A, crumbs cell polarity complex component | |
| Synonyms | ERP|NET|SAP-2|SAP2 | LIN-7A|LIN7|MALS-1|MALS1|TIP-33|VELI1 | |
| Cytomap | 12q23.1 | 12q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ETS domain-containing protein Elk-3ELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2 | protein lin-7 homolog Amammalian lin-seven protein 1tax interaction protein 33vertebrate LIN7 homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41970 | O14910 | |
| Ensembl transtripts involved in fusion gene | ENST00000228741, ENST00000552142, ENST00000549529, | ENST00000552864, | |
| Fusion gene scores | * DoF score | 10 X 3 X 4=120 | 12 X 5 X 4=240 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/120*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/240*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ELK3 [Title/Abstract] AND LIN7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ELK3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12933792 |
| Hgene | ELK3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12788937 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-3B-A9HO-01A | ELK3 | chr12 | 96617551 | + | LIN7A | chr12 | 81242101 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228741 | ENST00000552864 | ELK3 | chr12 | 96617551 | + | LIN7A | chr12 | 81242101 | - |
| In-frame | ENST00000552142 | ENST00000552864 | ELK3 | chr12 | 96617551 | + | LIN7A | chr12 | 81242101 | - |
| intron-3CDS | ENST00000549529 | ENST00000552864 | ELK3 | chr12 | 96617551 | + | LIN7A | chr12 | 81242101 | - |
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FusionProtFeatures for ELK3_LIN7A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELK3 | LIN7A |
| May be a negative regulator of transcription, but canactivate transcription when coexpressed with Ras, Src or Mos.Forms a ternary complex with the serum response factor and the ETSand SRF motifs of the Fos serum response element. | Plays a role in establishing and maintaining theasymmetric distribution of channels and receptors at the plasmamembrane of polarized cells. Forms membrane-associatedmultiprotein complexes that may regulate delivery and recycling ofproteins to the correct membrane domains. The tripartite complexcomposed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may havethe potential to couple synaptic vesicle exocytosis to celladhesion in brain. Ensures the proper localization of GRIN2B(subunit 2B of the NMDA receptor) to neuronal postsynaptic densityand may function in localizing synaptic vesicles at synapses whereit is recruited by beta-catenin and cadherin. Required to localizeKir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2,ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.{ECO:0000269|PubMed:12967566}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LIN7A | chr12:96617551 | chr12:81242101 | ENST00000552864 | - | 1 | 6 | 210_213 | 67 | 1908 | Compositional bias | Note=Poly-Gln |
| Tgene | >LIN7A | chr12:96617551 | chr12:81242101 | ENST00000552864 | - | 1 | 6 | 217_229 | 67 | 1908 | Compositional bias | Note=Poly-Gln |
| Tgene | >LIN7A | chr12:96617551 | chr12:81242101 | ENST00000552864 | - | 1 | 6 | 108_190 | 67 | 1908 | Domain | PDZ |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ELK3 | chr12:96617551 | chr12:81242101 | ENST00000228741 | + | 2 | 5 | 207_212 | 69 | 408 | Compositional bias | Note=Poly-Ala |
| Hgene | >ELK3 | chr12:96617551 | chr12:81242101 | ENST00000228741 | + | 2 | 5 | 5_85 | 69 | 408 | DNA binding | ETS |
| Hgene | >ELK3 | chr12:96617551 | chr12:81242101 | ENST00000228741 | + | 2 | 5 | 273_277 | 69 | 408 | Motif | Note=CTBP-binding motif |
| Tgene | LIN7A | chr12:96617551 | chr12:81242101 | ENST00000552864 | - | 1 | 6 | 25_80 | 67 | 1908 | Domain | L27 |
| Tgene | LIN7A | chr12:96617551 | chr12:81242101 | ENST00000552864 | - | 1 | 6 | 14_28 | 67 | 1908 | Motif | Note=Kinase interacting site |
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FusionGeneSequence for ELK3_LIN7A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ELK3_ENST00000228741_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_236aa MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKVYQYMHETITVNGCPEFRARA TAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAA >In-frame_ELK3_ENST00000552142_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_236aa MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKVYQYMHETITVNGCPEFRARA TAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ELK3_ENST00000228741_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_708nt ATGGAGAGTGCAATCACGCTGTGGCAGTTCCTGTTGCAGTTGCTGCTGGATCAGAAACATGAGCATTTGATCTGCTGGACCTCGAACGAT GGTGAATTCAAGCTCCTCAAAGCAGAAGAAGTGGCCAAGCTGTGGGGACTCCGAAAAAACAAAACAAATATGAACTATGATAAGCTGAGC AGAGCCCTGCGATACTATTATGACAAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCA ACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTT GGTTTTAATGTGATGGGAGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGC CTCAAAAGAGGAGACCAGCTGCTATCAGTGAACGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCT AAAGACAGCGTCAAGCTGGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGT >In-frame_ELK3_ENST00000552142_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_708nt ATGGAGAGTGCAATCACGCTGTGGCAGTTCCTGTTGCAGTTGCTGCTGGATCAGAAACATGAGCATTTGATCTGCTGGACCTCGAACGAT GGTGAATTCAAGCTCCTCAAAGCAGAAGAAGTGGCCAAGCTGTGGGGACTCCGAAAAAACAAAACAAATATGAACTATGATAAGCTGAGC AGAGCCCTGCGATACTATTATGACAAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCA ACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTT GGTTTTAATGTGATGGGAGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGC CTCAAAAGAGGAGACCAGCTGCTATCAGTGAACGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCT AAAGACAGCGTCAAGCTGGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ELK3_ENST00000228741_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_6241nt TGGGCGGCCAGCCCCGGCGCACAGCCGCGGCCGGGGCGCGCGGCGCGGGGCGGAAAAGCCTGTTTACACAGACTGCACACCGCCTGGGGA ATAATGCAGTAAAGGAAGTGAGCCGGCTCGGCCTGACTGCTCCAACTTCCTGCTCTCACACACACCAGAGGGGAAAAAAAAAGAGGAGCG AGAGAAAGAAAAAAAGGGGGAAAAATCAGGATCTCATTACAAGAGCCACAGACCGTCTGCAGACGCCTGTCAGCATGGAAAGTCGGGGGC TTTCGCCCGGGTCCTCCTAGAAATTCCCCCCGAAGAAGACTCCCCCACATCTGGGTATGGAGAGTGCAATCACGCTGTGGCAGTTCCTGT TGCAGTTGCTGCTGGATCAGAAACATGAGCATTTGATCTGCTGGACCTCGAACGATGGTGAATTCAAGCTCCTCAAAGCAGAAGAAGTGG CCAAGCTGTGGGGACTCCGAAAAAACAAAACAAATATGAACTATGATAAGCTGAGCAGAGCCCTGCGATACTATTATGACAAGGTGTATC AATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCAACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTA GTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTTGGTTTTAATGTGATGGGAGGAAAGGAGCAAAATT CCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGCCTCAAAAGAGGAGACCAGCTGCTATCAGTGAACG GAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCTAAAGACAGCGTCAAGCTGGTGGTGCGATACACCC CAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGTCGGCAGCAGCAGCAATTGCTAATTCAGCAGCAGC AACAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAGGCCCTTGAGGGAAAGCTACTTGATCAAACATCCGATAGTCACAAAT TTGAAACCGTGCTTCAGAATCCCAGCACATAGTAAAAGACAACACTGATAATTATACCTGTCAAGAAGCTGTGAACACATGGTGTATAAA TTCTTTACCAAGGCAACTCAACACCTTCTTTCTCTGGGCTTGAACCGCCACTGCTCACGTGGGCTTTACATACATTGACCTTCCATTCAC TGCAGTGGGAATTCTCAGTGTGCAGAGGGAGAGGTTTTCTAGTCTGCAAACTGAAACAGTGTAAGAAGAATAAAGTCTATGACTTTTAAA TAAATCACCAGGGCCAAGATTGAGTGAATCTTGGGTCCATAGCTTTTCCAGATATTAGCAAACCCCTCATTAGGCTATAATTCAAACTGC ATCAGTTCAAAGTGAAACCTACACATTGCTCCTTACCCTCACCTGCTCCACAATCCATAGTGCTGAGTTGTCTGAATTGGAATTCCAGTT AATTGCAAGTTCAACCTGTTTTCCTCTTGAAAATCGCAAGGTATCATACTATATTTATATTTTCTTCAGGTTCTAGAAGCAATCGGCTTT TTCTTTTGTTTCCATGAATTTTATTATGCATTAATAGAATGGACCAATTTTAGCTCAACTTTTAGTTTGTTAGAAGCAAGTGTAGGAACT CTAGCACTGTAGTTTTTAATTATTGCTTGTATCTATTATTATTAATTCCAACAGAGTATAATGTATATTTATTCTATAAAATATATATTA TCAGAGTGCATTTGTTACAACTTAGGTTCTTTTCTTACCAAGTATTAAGAATCTAGTAAGAGAATACTAGCAAAGGACCTAGCCCTGTGA ACAGATTCTCGTATGTTATATACATAAACCCACTCTCAATATTTTTTGAGTTTTATACTTTTTGATTGATAAACACTGAAGAAATCTAAA CTCTACTCACACTGATGTGCTGTCATAGAAGCCTATTTCATATTTTAAAGCTTAGCAAAACTAAATTATATGTGCATATATATTCAAATA TTTGTGTCACACAAAGTTTAGGTCAATTTCCCCAAATATAAACCAGATATTTTTGGCACTCTCAGATAAACAAGTATTATTTCTCTTATA ATTGGGCAGGTGGAAACCAGTGATATCAATATTGTGAATGGCAGATGCTGCTTCCTCTAGAAAAATAAAATAAAATCACCAACTTTAATA TATTCCCATAGGTAAATAGACAATGAGATATCATTTTTCAGAAAATATCATTCACTGGAAAATAATCTGTTATAACTACATTTACAGGTC ATAATTTTTGGTTTATGGTAAATCTAGGCACCTAAGTCTGATTTTACTTTATGAAATAAATAGGAAGCAATAATTGTTTGGGCATTTGAA TACCTTAAGCACATAAATGAACCTAAGAAAAGAATAATTGCTTAGTTGAAGTATTCAAAATAGATCAGTAAACCACAGGCAAATATTTGA ATGTTCCCTTTTCTCAAATACAGAAATTGATTCCCCAAGATACAATACAATTTGACACTTCAGATAATCCCCCAAAATAGAAATGTATGA AGCTCAGTTTAGACTGTCTTCTTGAAAATAAAACAAAACCAATCAAAACTACCCAGCACATTTTATTATGCCCTGTTGGGTGATAGTATT GTCAATACCAGGTTTTCCCTGCTCTTCACAATGCATCCCTCACCAGAGGAAAAACAGCAAGAAAACTAGGACATTTGCTAATTTCAACAA TACACCCCTGTGATAACAGATTCCCATCCTTGAATACATATCATTTTTTACTAGAGAGAACGGGGGTGGTGAGGTGGGGGCAGTTAGGAC CCTGTATGTTATGTAAAATAGATTTACAAAAAGGACAAGCATGATAAAAGGGAATGAATGGAGACGATGTATTATTCAGTTTGAAAGAGA TAGTTCACATTTTTATAAGAAAAATTTAATAAAACATATATTTTAGTTATCATTTAACAAAGATATATTAAAGCTATTCAGGCAATGCCA CAGGATTCTCATGAAGGGAAATCACTGAACCCTTGTCATGAGAAAATGGTCATTTCAACACATTTCAATACATTGTATAAATTTGGAGCT TAAGGTGAGTGAGTATGTTTTCACTTAGTCATAAATGTTTGGTCAAAATTAAAGTTATCATATGGTTTCACATCAATACAAATATTGTCA CAGTGTTACAGAAACAACTATCAAATGGTAAGATAGTTTACATTTGTGTTTTCTAGAAACCTTTGTATTTATGCTTCATTTGGTTAATGT TAAGTGCTGATAAAGGCATACCAGATTGTTTGTCAAAGTAAAGAAGCAATCCATCACACCTAGGACATCTAAGGATGGATTATACGTCAG AGTGGTCTCATATACAAATGACCATTTTCCTTCAGTAAAATCTTGTTGGTTGAAATGTAAGTCTTTTCCTAAAGTTTTAATCAGAGGTAG CCATCACTAAGACTTAAGCCACCTGTGGTTCTCTTAAGTTTCACTGAAGCCAGAAGAAGGAAATTACCACAACTTGTATTATACTAATTA TCTTCATTATTAACGATCATATTAGAGCCACTGACATGTCCCAAATTATATTAAAATAAAAACCTGCATTGCTCTGACATGAAGCTCAAT TCAATGTAATAAACAAATTAGGTATTAAACGTTATAATTTAAAAAACTTCTACGATATCACCAGAAATCCTGGTGAAATTTAATTTTTTC CCTTTTTTAGGTCAGTGGCCGGTGGGATAGATTTTTCTAAACTTTTTCCTGCTATGATTTTGAAGGCAAATACATAGAGCACAGTTCAGT AAAAGAGTTTCCAAGCCTTTTCACTGGAGCATTTACATTTTGATTCTGTTGTCATTTGAAATAGAACATCTGCAGGGAGATAATGAGCTT AAGTTACAATTGACTTTGGAAAGAATAACAGACTTTTGTGTTTCCTCAATCATGTAGTCAATAGGGAATTCTCCAGTTATGTGAACAATC ACAGTCTTTTAAGACAATACTTAGATCTAAATGCAAAATCTAGCATGCAGAGGCTTTTTAAGGATTTTAGACTGTCTCCAAAGAACTTGG CTCGAGATGGATTACACAGATTTACAAATGCAGTTTTCAACTGTGACATCAAACTGATCTTATCTCATTTCATGTTACTCAACTGTGCCC GTAGGACCCCAAGAGGTGGAATATTTTGTCTACATTATTTTAAACATCTATAGATATGTGTGGATGTGTGAATAATGCCTAAATTTCTCA TCTTTTAACTAGTTTGTTTTTATCATACAGACACAGCCTGTTCATAAGACCAGCTTTAGACAACTTAGAACTCAATGCTCTGAAGATTCA GGGAGGCCAACATAGAAAAAGATCTTCCAAAATATGGGGTGGTCCAACCCATCTCATCCCTCTCTAGCTGGAAAACTATAGAGAAAGGGC TGTGACTGCCTTGACCACTGCCTGGCACAATGTAGGCACTCGGTATTTGTTGGATGAATAAGTGGCTGAATCAGTGAATAGACAAAAAAC ATGGATTTTGCCTTCTGAAAATCTCACAAATTTTACCAGCTTATATTATACTGATTGTCACTATGATTTCTAAGTTTCATGGTTAGAACC ATATTTTGAGTCTATATAAAAACTTTTTAGATGTATGAATTTGAAATTTCATTAATTACTTTAAAGGCTTCAAAGATTTGAGGACATTTG AACAGTGGATAAGGAACAATGTTTGGGGATACAGAGTTTTTATGCTGAGTTGAACTCAACCTTTCTAGTTCTTTATACAAGCTTCCTGAA TTATCTGGCAGGAATGATTCAAACATAAAACCCCATTTTTAAATTTTATAAAAGATATTTTCATTTTTATATAAAAAGATCATCAGGCAT ATTATCCCCTTTGATATTTATTAACAACCATTCTCTAAGAAATTCATAATAATTGGAGACACCATCCCTAAATCTCTTCCTATTTTCAAA AGATCATTTATCCTTTCATATTTGATTCCTGGAATACACTAAGCTGAAGTTTAATCACATACTTACTCAGATGTTTCCATGTGTTTATTC ATTTAACAAATACTTATTGTGTACCTAGTGCATGCTAGGTTCTGGAAATGCAACAGCAAACAAGACAGACACAATCCCTCTTGGAGGTTA CTGTGAGAAACTCTCCAACATTTACTCTAGCAATAACTAGAGAGTTTACTGTCCATTGGGTCCTCTTCACACCTGATAGAAAAAATAAAA TTCCTCACCCCATGGAAGTCATGAAATACTCCCTGCACAGATTTGTGTGAGCTTGCTTTTCTAAAACCACTGCTCAAAAATGCTGCTTAG TTTATCTATAAACCACGGTTATACCCCAGTGAGGTAGGTAAGTAATTTATTCATAACTAACATTTATGCAGCTCTATTTTCTAGCCACTG TGCTGAGTGCTTTTATGGACTATCTCACCAAATCCCTTCAACAACTCTATTCAGTAGGTTCCATTTTATAGATACAAAAACTGAAGCACA GATATATTATGTGACTTGTCCAAGGTCACACAGCTAGCAGGTGGAACTGGGATTTGAACCCATGCAATCTGACACAAGAGTTCATGTGTC TAATCATTATCTGTGGTTTGGGGGACACCATTACATTAAAATGAATGAGTCACTAAGTGAGTCACTGTATATAAAATACTTGGAAATTGT AAAGTAATATACAAAAGATATTAACAAAGTATTATTCATGGTAAACAAATCACATCAGTAGCAAACACAGGGTGGGAACTCAATCTTATG TTATAGCTTACTCTTAAGAAGAATATGTGAAGCCAGGAACATGGTTAAAGGTACAGACCAGAAAATTTCTGACATGTGATAAATATTTCA GTGACTTTTCAGATTTATTTCTTGTTAGCCGCTGTGTCTATTTGGTGCTACAAAAACTGAAAGAAACAAAATCCCTGATGTAAGGGCTTA TAATAAATACACAGTTTGGAGATGAACTAAGGATATTTTACATTTACGGGAAAGGATTGGACAATAGTATCATTTTCTCACCATTTGCAT GTACATCATGTCTTTCCAATTGTTTTCATTATTTTTCTGAAAGAGCTGCAAAATTGTGCAGTGGTTCAACCTGACCAAAGTGGTATTATG >In-frame_ELK3_ENST00000552142_chr12_96617551_+_LIN7A_ENST00000552864_chr12_81242101_-_6078nt AAAAAAAAAGAGGAGCGAGAGAAAGAAAAAAAGGGGGAAAAATCAGGATCTCATTACAAGAGCCACAGACCGTCTGCAGACGCCTGTCAG CATGGAAAGTCGGGGGCTTTCGCCCGGGTCCTCCTAGAAATTCCCCCCGAAGAAGACTCCCCCACATCTGGGTATGGAGAGTGCAATCAC GCTGTGGCAGTTCCTGTTGCAGTTGCTGCTGGATCAGAAACATGAGCATTTGATCTGCTGGACCTCGAACGATGGTGAATTCAAGCTCCT CAAAGCAGAAGAAGTGGCCAAGCTGTGGGGACTCCGAAAAAACAAAACAAATATGAACTATGATAAGCTGAGCAGAGCCCTGCGATACTA TTATGACAAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCAACAGCAAAGGCAACAGT TGCAGCTTTTGCAGCTAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTTGGTTTTAATGTGATGGG AGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGCCTCAAAAGAGGAGACCA GCTGCTATCAGTGAACGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCTAAAGACAGCGTCAAGCT GGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGTCGGCAGCAGCAGCAATT GCTAATTCAGCAGCAGCAACAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAGGCCCTTGAGGGAAAGCTACTTGATCAAAC ATCCGATAGTCACAAATTTGAAACCGTGCTTCAGAATCCCAGCACATAGTAAAAGACAACACTGATAATTATACCTGTCAAGAAGCTGTG AACACATGGTGTATAAATTCTTTACCAAGGCAACTCAACACCTTCTTTCTCTGGGCTTGAACCGCCACTGCTCACGTGGGCTTTACATAC ATTGACCTTCCATTCACTGCAGTGGGAATTCTCAGTGTGCAGAGGGAGAGGTTTTCTAGTCTGCAAACTGAAACAGTGTAAGAAGAATAA AGTCTATGACTTTTAAATAAATCACCAGGGCCAAGATTGAGTGAATCTTGGGTCCATAGCTTTTCCAGATATTAGCAAACCCCTCATTAG GCTATAATTCAAACTGCATCAGTTCAAAGTGAAACCTACACATTGCTCCTTACCCTCACCTGCTCCACAATCCATAGTGCTGAGTTGTCT GAATTGGAATTCCAGTTAATTGCAAGTTCAACCTGTTTTCCTCTTGAAAATCGCAAGGTATCATACTATATTTATATTTTCTTCAGGTTC TAGAAGCAATCGGCTTTTTCTTTTGTTTCCATGAATTTTATTATGCATTAATAGAATGGACCAATTTTAGCTCAACTTTTAGTTTGTTAG AAGCAAGTGTAGGAACTCTAGCACTGTAGTTTTTAATTATTGCTTGTATCTATTATTATTAATTCCAACAGAGTATAATGTATATTTATT CTATAAAATATATATTATCAGAGTGCATTTGTTACAACTTAGGTTCTTTTCTTACCAAGTATTAAGAATCTAGTAAGAGAATACTAGCAA AGGACCTAGCCCTGTGAACAGATTCTCGTATGTTATATACATAAACCCACTCTCAATATTTTTTGAGTTTTATACTTTTTGATTGATAAA CACTGAAGAAATCTAAACTCTACTCACACTGATGTGCTGTCATAGAAGCCTATTTCATATTTTAAAGCTTAGCAAAACTAAATTATATGT GCATATATATTCAAATATTTGTGTCACACAAAGTTTAGGTCAATTTCCCCAAATATAAACCAGATATTTTTGGCACTCTCAGATAAACAA GTATTATTTCTCTTATAATTGGGCAGGTGGAAACCAGTGATATCAATATTGTGAATGGCAGATGCTGCTTCCTCTAGAAAAATAAAATAA AATCACCAACTTTAATATATTCCCATAGGTAAATAGACAATGAGATATCATTTTTCAGAAAATATCATTCACTGGAAAATAATCTGTTAT AACTACATTTACAGGTCATAATTTTTGGTTTATGGTAAATCTAGGCACCTAAGTCTGATTTTACTTTATGAAATAAATAGGAAGCAATAA TTGTTTGGGCATTTGAATACCTTAAGCACATAAATGAACCTAAGAAAAGAATAATTGCTTAGTTGAAGTATTCAAAATAGATCAGTAAAC CACAGGCAAATATTTGAATGTTCCCTTTTCTCAAATACAGAAATTGATTCCCCAAGATACAATACAATTTGACACTTCAGATAATCCCCC AAAATAGAAATGTATGAAGCTCAGTTTAGACTGTCTTCTTGAAAATAAAACAAAACCAATCAAAACTACCCAGCACATTTTATTATGCCC TGTTGGGTGATAGTATTGTCAATACCAGGTTTTCCCTGCTCTTCACAATGCATCCCTCACCAGAGGAAAAACAGCAAGAAAACTAGGACA TTTGCTAATTTCAACAATACACCCCTGTGATAACAGATTCCCATCCTTGAATACATATCATTTTTTACTAGAGAGAACGGGGGTGGTGAG GTGGGGGCAGTTAGGACCCTGTATGTTATGTAAAATAGATTTACAAAAAGGACAAGCATGATAAAAGGGAATGAATGGAGACGATGTATT ATTCAGTTTGAAAGAGATAGTTCACATTTTTATAAGAAAAATTTAATAAAACATATATTTTAGTTATCATTTAACAAAGATATATTAAAG CTATTCAGGCAATGCCACAGGATTCTCATGAAGGGAAATCACTGAACCCTTGTCATGAGAAAATGGTCATTTCAACACATTTCAATACAT TGTATAAATTTGGAGCTTAAGGTGAGTGAGTATGTTTTCACTTAGTCATAAATGTTTGGTCAAAATTAAAGTTATCATATGGTTTCACAT CAATACAAATATTGTCACAGTGTTACAGAAACAACTATCAAATGGTAAGATAGTTTACATTTGTGTTTTCTAGAAACCTTTGTATTTATG CTTCATTTGGTTAATGTTAAGTGCTGATAAAGGCATACCAGATTGTTTGTCAAAGTAAAGAAGCAATCCATCACACCTAGGACATCTAAG GATGGATTATACGTCAGAGTGGTCTCATATACAAATGACCATTTTCCTTCAGTAAAATCTTGTTGGTTGAAATGTAAGTCTTTTCCTAAA GTTTTAATCAGAGGTAGCCATCACTAAGACTTAAGCCACCTGTGGTTCTCTTAAGTTTCACTGAAGCCAGAAGAAGGAAATTACCACAAC TTGTATTATACTAATTATCTTCATTATTAACGATCATATTAGAGCCACTGACATGTCCCAAATTATATTAAAATAAAAACCTGCATTGCT CTGACATGAAGCTCAATTCAATGTAATAAACAAATTAGGTATTAAACGTTATAATTTAAAAAACTTCTACGATATCACCAGAAATCCTGG TGAAATTTAATTTTTTCCCTTTTTTAGGTCAGTGGCCGGTGGGATAGATTTTTCTAAACTTTTTCCTGCTATGATTTTGAAGGCAAATAC ATAGAGCACAGTTCAGTAAAAGAGTTTCCAAGCCTTTTCACTGGAGCATTTACATTTTGATTCTGTTGTCATTTGAAATAGAACATCTGC AGGGAGATAATGAGCTTAAGTTACAATTGACTTTGGAAAGAATAACAGACTTTTGTGTTTCCTCAATCATGTAGTCAATAGGGAATTCTC CAGTTATGTGAACAATCACAGTCTTTTAAGACAATACTTAGATCTAAATGCAAAATCTAGCATGCAGAGGCTTTTTAAGGATTTTAGACT GTCTCCAAAGAACTTGGCTCGAGATGGATTACACAGATTTACAAATGCAGTTTTCAACTGTGACATCAAACTGATCTTATCTCATTTCAT GTTACTCAACTGTGCCCGTAGGACCCCAAGAGGTGGAATATTTTGTCTACATTATTTTAAACATCTATAGATATGTGTGGATGTGTGAAT AATGCCTAAATTTCTCATCTTTTAACTAGTTTGTTTTTATCATACAGACACAGCCTGTTCATAAGACCAGCTTTAGACAACTTAGAACTC AATGCTCTGAAGATTCAGGGAGGCCAACATAGAAAAAGATCTTCCAAAATATGGGGTGGTCCAACCCATCTCATCCCTCTCTAGCTGGAA AACTATAGAGAAAGGGCTGTGACTGCCTTGACCACTGCCTGGCACAATGTAGGCACTCGGTATTTGTTGGATGAATAAGTGGCTGAATCA GTGAATAGACAAAAAACATGGATTTTGCCTTCTGAAAATCTCACAAATTTTACCAGCTTATATTATACTGATTGTCACTATGATTTCTAA GTTTCATGGTTAGAACCATATTTTGAGTCTATATAAAAACTTTTTAGATGTATGAATTTGAAATTTCATTAATTACTTTAAAGGCTTCAA AGATTTGAGGACATTTGAACAGTGGATAAGGAACAATGTTTGGGGATACAGAGTTTTTATGCTGAGTTGAACTCAACCTTTCTAGTTCTT TATACAAGCTTCCTGAATTATCTGGCAGGAATGATTCAAACATAAAACCCCATTTTTAAATTTTATAAAAGATATTTTCATTTTTATATA AAAAGATCATCAGGCATATTATCCCCTTTGATATTTATTAACAACCATTCTCTAAGAAATTCATAATAATTGGAGACACCATCCCTAAAT CTCTTCCTATTTTCAAAAGATCATTTATCCTTTCATATTTGATTCCTGGAATACACTAAGCTGAAGTTTAATCACATACTTACTCAGATG TTTCCATGTGTTTATTCATTTAACAAATACTTATTGTGTACCTAGTGCATGCTAGGTTCTGGAAATGCAACAGCAAACAAGACAGACACA ATCCCTCTTGGAGGTTACTGTGAGAAACTCTCCAACATTTACTCTAGCAATAACTAGAGAGTTTACTGTCCATTGGGTCCTCTTCACACC TGATAGAAAAAATAAAATTCCTCACCCCATGGAAGTCATGAAATACTCCCTGCACAGATTTGTGTGAGCTTGCTTTTCTAAAACCACTGC TCAAAAATGCTGCTTAGTTTATCTATAAACCACGGTTATACCCCAGTGAGGTAGGTAAGTAATTTATTCATAACTAACATTTATGCAGCT CTATTTTCTAGCCACTGTGCTGAGTGCTTTTATGGACTATCTCACCAAATCCCTTCAACAACTCTATTCAGTAGGTTCCATTTTATAGAT ACAAAAACTGAAGCACAGATATATTATGTGACTTGTCCAAGGTCACACAGCTAGCAGGTGGAACTGGGATTTGAACCCATGCAATCTGAC ACAAGAGTTCATGTGTCTAATCATTATCTGTGGTTTGGGGGACACCATTACATTAAAATGAATGAGTCACTAAGTGAGTCACTGTATATA AAATACTTGGAAATTGTAAAGTAATATACAAAAGATATTAACAAAGTATTATTCATGGTAAACAAATCACATCAGTAGCAAACACAGGGT GGGAACTCAATCTTATGTTATAGCTTACTCTTAAGAAGAATATGTGAAGCCAGGAACATGGTTAAAGGTACAGACCAGAAAATTTCTGAC ATGTGATAAATATTTCAGTGACTTTTCAGATTTATTTCTTGTTAGCCGCTGTGTCTATTTGGTGCTACAAAAACTGAAAGAAACAAAATC CCTGATGTAAGGGCTTATAATAAATACACAGTTTGGAGATGAACTAAGGATATTTTACATTTACGGGAAAGGATTGGACAATAGTATCAT TTTCTCACCATTTGCATGTACATCATGTCTTTCCAATTGTTTTCATTATTTTTCTGAAAGAGCTGCAAAATTGTGCAGTGGTTCAACCTG |
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FusionGenePPI for ELK3_LIN7A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ELK3 | TCF3, TOP1, APP | LIN7A | KCNJ12, KCNJ4, DLG1, CASK, MPP6, DLG4, GRIN2B, AMOT, APP, MPP5, BAI1, GOLGA2, MPP2, MPP3, ZYX, FAM9B, NOTCH2NL, FAM188A, CADM1, EPB41L2, GUCY1A2, GUCY1B3, INADL, MPDZ, MPP7, PIP4K2B, PXDC1, SLC20A1, SNTB2, CDA, NSUN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELK3_LIN7A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELK3_LIN7A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ELK3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | LIN7A | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | LIN7A | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | LIN7A | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
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