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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11406

FusionGeneSummary for ELK1_PCBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: ELK1_PCBP3
Fusion gene ID: 11406
HgeneTgene
Gene symbol

ELK1

PCBP3

Gene ID

131096

54039

Gene namepotassium voltage-gated channel subfamily H member 8poly(rC) binding protein 3
SynonymsELK|ELK1|Kv12.1|elk3ALPHA-CP3|PCBP3-OT1|PCBP3OT
Cytomap

3p24.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily H member 8ELK channel 3ether-a-go-go-like potassium channel 1ether-a-go-go-like potassium channel 3hElk1potassium channel, voltage gated eag related subfamily H, member 8potassium voltage-gated channel, subfpoly(rC)-binding protein 3PCBP3 overlapping transcript 1PCBP3-overlapping transcriptpoly(rC) binding protein 3 overlapping transcript
Modification date2018052320180519
UniProtAcc

P19419

P57721

Ensembl transtripts involved in fusion geneENST00000247161, ENST00000592066, 
ENST00000376983, ENST00000343894, 
ENST00000468956, 
ENST00000400314, 
ENST00000400310, ENST00000449640, 
ENST00000400309, ENST00000400308, 
ENST00000400304, ENST00000423045, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 4=64
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELK1 [Title/Abstract] AND PCBP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-ND-A4W6-01AELK1chrX

47509822

-PCBP3chr21

47269875

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000247161ENST00000400314ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000247161ENST00000400310ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000247161ENST00000449640ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000247161ENST00000400309ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000247161ENST00000400308ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000247161ENST00000400304ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000247161ENST00000423045ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000592066ENST00000400314ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000592066ENST00000400310ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000592066ENST00000449640ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000592066ENST00000400309ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000592066ENST00000400308ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000592066ENST00000400304ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000592066ENST00000423045ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000376983ENST00000400314ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000376983ENST00000400310ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000376983ENST00000449640ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000376983ENST00000400309ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000376983ENST00000400308ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000376983ENST00000400304ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000376983ENST00000423045ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000343894ENST00000400314ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000343894ENST00000400310ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000343894ENST00000449640ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000343894ENST00000400309ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000343894ENST00000400308ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000343894ENST00000400304ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000343894ENST00000423045ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000468956ENST00000400314ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000468956ENST00000400310ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000468956ENST00000449640ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000468956ENST00000400309ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-5UTRENST00000468956ENST00000400308ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000468956ENST00000400304ELK1chrX

47509822

-PCBP3chr21

47269875

+
5UTR-intronENST00000468956ENST00000423045ELK1chrX

47509822

-PCBP3chr21

47269875

+

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FusionProtFeatures for ELK1_PCBP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELK1

P19419

PCBP3

P57721

Transcription factor that binds to purine-rich DNAsequences. Forms a ternary complex with SRF and the ETS and SRFmotifs of the serum response element (SRE) on the promoter regionof immediate early genes such as FOS and IER2. Induces target genetranscription upon JNK-signaling pathway stimulation (Bysimilarity). {ECO:0000250|UniProtKB:A4GTP4,ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. Single-stranded nucleic acid binding protein that bindspreferentially to oligo dC. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELK1_PCBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELK1_PCBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELK1MAPK1, EP300, FLI1, SRF, EWSR1, STK16, MAPK8, EMX1, HOXB13, KLF4, HDAC1, MAPK3, ELAVL1, PADI4, MAD2L2, SNCA, APP, MAPK9, MAPK10, UBE2I, CDK6, FBXO25, ELK1, STARD3NL, CREBBP, CRK, PLCG2PCBP3RUVBL1, RUVBL2, RBM39, PTBP1, PTBP2, SPEN, PFKL, FAM96B, FTH1, PCBP1, RHOD, KCTD17, AKR1B10, TSTA3, PDCD2L, DLD, PPP1R18, DCP2, BBOX1, PCM1, CEP128, CDC73, HDAC10, WNT16, TYW3, COLGALT2, CCDC6, GBP2, METTL25, DVL3, OCRL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELK1_PCBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELK1_PCBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource