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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11383

FusionGeneSummary for ELAC1_MRO

check button Fusion gene summary
Fusion gene informationFusion gene name: ELAC1_MRO
Fusion gene ID: 11383
HgeneTgene
Gene symbol

ELAC1

MRO

Gene ID

55520

83876

Gene nameelaC ribonuclease Z 1maestro
SynonymsD29B29|C18orf3
Cytomap

18q21.2

18q21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc phosphodiesterase ELAC protein 1RNase Z 1RNaseZ(S)deleted in Ma29elaC homolog 1elaC homolog protein 1ribonuclease Z 1tRNA 3 endonuclease 1tRNA 3' processing endoribonucleasetRNA Z (short form)tRNase Z 1tRNase ZSprotein maestrobeside the Ma29 deletionmale-specific transcription in the developing reproductive organs
Modification date2018052320180402
UniProtAcc

Q9H777

Q9BYG7

Ensembl transtripts involved in fusion geneENST00000588577, ENST00000269466, 
ENST00000591429, ENST00000586966, 
ENST00000428869, ENST00000431965, 
ENST00000256425, ENST00000588444, 
ENST00000436348, ENST00000398439, 
ENST00000587291, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ELAC1 [Title/Abstract] AND MRO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-4371-01AELAC1chr18

48510933

+MROchr18

48335774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000588577ENST00000428869ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000588577ENST00000431965ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000588577ENST00000256425ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000588577ENST00000588444ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000588577ENST00000436348ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000588577ENST00000398439ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000588577ENST00000587291ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000269466ENST00000428869ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000269466ENST00000431965ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000269466ENST00000256425ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000269466ENST00000588444ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000269466ENST00000436348ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000269466ENST00000398439ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000269466ENST00000587291ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000591429ENST00000428869ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000591429ENST00000431965ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000591429ENST00000256425ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000591429ENST00000588444ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000591429ENST00000436348ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-5UTRENST00000591429ENST00000398439ELAC1chr18

48510933

+MROchr18

48335774

-
5CDS-intronENST00000591429ENST00000587291ELAC1chr18

48510933

+MROchr18

48335774

-
intron-5UTRENST00000586966ENST00000428869ELAC1chr18

48510933

+MROchr18

48335774

-
intron-intronENST00000586966ENST00000431965ELAC1chr18

48510933

+MROchr18

48335774

-
intron-5UTRENST00000586966ENST00000256425ELAC1chr18

48510933

+MROchr18

48335774

-
intron-5UTRENST00000586966ENST00000588444ELAC1chr18

48510933

+MROchr18

48335774

-
intron-intronENST00000586966ENST00000436348ELAC1chr18

48510933

+MROchr18

48335774

-
intron-5UTRENST00000586966ENST00000398439ELAC1chr18

48510933

+MROchr18

48335774

-
intron-intronENST00000586966ENST00000587291ELAC1chr18

48510933

+MROchr18

48335774

-

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FusionProtFeatures for ELAC1_MRO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELAC1

Q9H777

MRO

Q9BYG7

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNAmaturation, by removing a 3'-trailer from precursor tRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELAC1_MRO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELAC1_MRO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELAC1MRO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELAC1_MRO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELAC1_MRO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMROC0023893Liver Cirrhosis, Experimental1CTD_human