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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11373

FusionGeneSummary for EIF5B_CCDC113

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF5B_CCDC113
Fusion gene ID: 11373
HgeneTgene
Gene symbol

EIF5B

CCDC113

Gene ID

9669

29070

Gene nameeukaryotic translation initiation factor 5Bcoiled-coil domain containing 113
SynonymsIF2HSPC065
Cytomap

2q11.2

16q21

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 5BeIF-5Btranslation initiation factor IF-2translation initiation factor IF2coiled-coil domain-containing protein 113
Modification date2018052320180519
UniProtAcc

O60841

Q9H0I3

Ensembl transtripts involved in fusion geneENST00000289371, ENST00000219299, 
ENST00000443128, ENST00000566498, 
Fusion gene scores* DoF score5 X 7 X 3=1052 X 2 X 2=8
# samples 82
** MAII scorelog2(8/105*10)=-0.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: EIF5B [Title/Abstract] AND CCDC113 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF5B

GO:0006446

regulation of translational initiation

10432305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB243572EIF5Bchr2

99984951

-CCDC113chr16

58317310

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000289371ENST00000219299EIF5Bchr2

99984951

-CCDC113chr16

58317310

+
intron-3UTRENST00000289371ENST00000443128EIF5Bchr2

99984951

-CCDC113chr16

58317310

+
intron-intronENST00000289371ENST00000566498EIF5Bchr2

99984951

-CCDC113chr16

58317310

+

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FusionProtFeatures for EIF5B_CCDC113


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF5B

O60841

CCDC113

Q9H0I3

Plays a role in translation initiation. TranslationalGTPase that catalyzes the joining of the 40S and 60S subunits toform the 80S initiation complex with the initiator methionine-tRNAin the P-site base paired to the start codon. GTP binding andhydrolysis induces conformational changes in the enzyme thatrenders it active for productive interactions with the ribosome.The release of the enzyme after formation of the initiationcomplex is a prerequisite to form elongation-competent ribosomes.{ECO:0000250|UniProtKB:P39730}. Component of centriolar satellites contributing toprimary cilium formation. {ECO:0000269|PubMed:25074808}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF5B_CCDC113


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF5B_CCDC113


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF5B_CCDC113


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF5B_CCDC113


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource