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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11341

FusionGeneSummary for EIF4G2_IFT46

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G2_IFT46
Fusion gene ID: 11341
HgeneTgene
Gene symbol

EIF4G2

IFT46

Gene ID

1982

56912

Gene nameeukaryotic translation initiation factor 4 gamma 2intraflagellar transport 46
SynonymsAAG1|DAP5|NAT1|P97C11orf2|C11orf60|CFAP32
Cytomap

11p15.4

11q23.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 2DAP-5aging-associated protein 1death-associated protein 5eIF-4-gamma 2eIF-4G 2eIF4G 2eukaryotic translation initiation factor 4G-like 1intraflagellar transport protein 46 homologUPF0360cilia and flagella associated protein 32intraflagellar transport 46 homologintraflagellar transport protein IFT46
Modification date2018052320180523
UniProtAcc

P78344

Q9NQC8

Ensembl transtripts involved in fusion geneENST00000526148, ENST00000525681, 
ENST00000339995, ENST00000396525, 
ENST00000525995, 
ENST00000264021, 
ENST00000264020, ENST00000530872, 
ENST00000527868, 
Fusion gene scores* DoF score15 X 15 X 7=15753 X 4 X 2=24
# samples 214
** MAII scorelog2(21/1575*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF4G2 [Title/Abstract] AND IFT46 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G2

GO:0006446

regulation of translational initiation

11943866


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE927811EIF4G2chr11

10821154

-IFT46chr11

118432165

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000526148ENST00000264021EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000526148ENST00000264020EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000526148ENST00000530872EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000526148ENST00000527868EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525681ENST00000264021EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525681ENST00000264020EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525681ENST00000530872EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525681ENST00000527868EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000339995ENST00000264021EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000339995ENST00000264020EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000339995ENST00000530872EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000339995ENST00000527868EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000396525ENST00000264021EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000396525ENST00000264020EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000396525ENST00000530872EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000396525ENST00000527868EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525995ENST00000264021EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525995ENST00000264020EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525995ENST00000530872EIF4G2chr11

10821154

-IFT46chr11

118432165

+
intron-intronENST00000525995ENST00000527868EIF4G2chr11

10821154

-IFT46chr11

118432165

+

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FusionProtFeatures for EIF4G2_IFT46


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G2

P78344

IFT46

Q9NQC8

Forms part of a complex involved in intraflagellartransport (IFT), the bi-directional movement of particles requiredfor the assembly, maintenance and functioning of primary cilia.May play a role in chondrocyte maturation and skeletogenesis (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4G2_IFT46


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G2_IFT46


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4G2_IFT46


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4G2_IFT46


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource