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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11332

FusionGeneSummary for EIF4G1_TPM2

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G1_TPM2
Fusion gene ID: 11332
HgeneTgene
Gene symbol

EIF4G1

TPM2

Gene ID

1981

7169

Gene nameeukaryotic translation initiation factor 4 gamma 1tropomyosin 2
SynonymsEIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18AMCD1|DA1|DA2B|HEL-S-273|NEM4|TMSB
Cytomap

3q27.1

9p13.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 1EIF4-gammaeIF-4-gamma 1eucaryotic translation initiation factor 4Gtropomyosin beta chainepididymis secretory protein Li 273nemaline myopathy type 4tropomyosin 2 (beta)
Modification date2018052320180523
UniProtAcc

Q04637

P07951

Ensembl transtripts involved in fusion geneENST00000346169, ENST00000414031, 
ENST00000392537, ENST00000382330, 
ENST00000350481, ENST00000352767, 
ENST00000427845, ENST00000342981, 
ENST00000319274, ENST00000424196, 
ENST00000411531, ENST00000441154, 
ENST00000434061, ENST00000435046, 
ENST00000378300, ENST00000378292, 
ENST00000329305, ENST00000360958, 
Fusion gene scores* DoF score9 X 11 X 6=5948 X 8 X 2=128
# samples 1410
** MAII scorelog2(14/594*10)=-2.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/128*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4G1 [Title/Abstract] AND TPM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G1

GO:1905612

positive regulation of mRNA cap binding

23409027

HgeneEIF4G1

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027

TgeneTPM2

GO:0043462

regulation of ATPase activity

17194691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW859459EIF4G1chr3

184040401

+TPM2chr9

35685776

-
ChiTaRS3.1AW859452EIF4G1chr3

184040401

+TPM2chr9

35685776

-
ChiTaRS3.1AW859462EIF4G1chr3

184040401

+TPM2chr9

35685776

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000346169ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000346169ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000346169ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000346169ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000414031ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000414031ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000414031ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000414031ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000392537ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000392537ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000392537ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000392537ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000382330ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000382330ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000382330ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000382330ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000350481ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000350481ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000350481ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000350481ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000352767ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000352767ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000352767ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000352767ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000427845ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000427845ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000427845ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000427845ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000342981ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000342981ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000342981ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000342981ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000319274ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000319274ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000319274ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000319274ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000424196ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000424196ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000424196ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000424196ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000411531ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000411531ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000411531ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000411531ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000441154ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000441154ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000441154ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000441154ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000434061ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000434061ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000434061ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000434061ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000435046ENST00000378300EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000435046ENST00000378292EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000435046ENST00000329305EIF4G1chr3

184040401

+TPM2chr9

35685776

-
Frame-shiftENST00000435046ENST00000360958EIF4G1chr3

184040401

+TPM2chr9

35685776

-

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FusionProtFeatures for EIF4G1_TPM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G1

Q04637

TPM2

P07951

Binds to actin filaments in muscle and non-muscle cells.Plays a central role, in association with the troponin complex, inthe calcium dependent regulation of vertebrate striated musclecontraction. Smooth muscle contraction is regulated by interactionwith caldesmon. In non-muscle cells is implicated in stabilizingcytoskeleton actin filaments. The non-muscle isoform may have arole in agonist-mediated receptor internalization.{ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4G1_TPM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G1_TPM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4G1_TPM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4G1_TPM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF4G1C3280271PARKINSON DISEASE 181UNIPROT
TgeneTPM2C1836447Nemaline myopathy 44CTD_human;ORPHANET;UNIPROT
TgeneTPM2C0220662ARTHROGRYPOSIS, DISTAL, TYPE 13CTD_human;ORPHANET;UNIPROT
TgeneTPM2C1834523ARTHROGRYPOSIS, DISTAL, TYPE 2B2CTD_human;ORPHANET;UNIPROT
TgeneTPM2C0279626Squamous cell carcinoma of esophagus1CTD_human