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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11326

FusionGeneSummary for EIF4G1_ANKS1A

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G1_ANKS1A
Fusion gene ID: 11326
HgeneTgene
Gene symbol

EIF4G1

ANKS1A

Gene ID

1981

23294

Gene nameeukaryotic translation initiation factor 4 gamma 1ankyrin repeat and sterile alpha motif domain containing 1A
SynonymsEIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18ANKS1
Cytomap

3q27.1

6p21.31

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 1EIF4-gammaeIF-4-gamma 1eucaryotic translation initiation factor 4Gankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1
Modification date2018052320180522
UniProtAcc

Q04637

Q92625

Ensembl transtripts involved in fusion geneENST00000346169, ENST00000414031, 
ENST00000392537, ENST00000382330, 
ENST00000350481, ENST00000352767, 
ENST00000427845, ENST00000342981, 
ENST00000319274, ENST00000424196, 
ENST00000411531, ENST00000441154, 
ENST00000434061, ENST00000435046, 
ENST00000360359, ENST00000535627, 
ENST00000470698, 
Fusion gene scores* DoF score9 X 11 X 6=59426 X 6 X 14=2184
# samples 1428
** MAII scorelog2(14/594*10)=-2.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(28/2184*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4G1 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G1

GO:1905612

positive regulation of mRNA cap binding

23409027

HgeneEIF4G1

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-5879-01AEIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346169ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000346169ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000346169ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000414031ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000414031ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000414031ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000392537ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000392537ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000392537ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000382330ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000382330ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000382330ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000350481ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000350481ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000350481ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000352767ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000352767ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000352767ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000427845ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000427845ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000427845ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
3UTR-intronENST00000342981ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
3UTR-intronENST00000342981ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
3UTR-intronENST00000342981ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000319274ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000319274ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000319274ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000424196ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000424196ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000424196ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000411531ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000411531ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000411531ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000441154ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000441154ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
intron-intronENST00000441154ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000434061ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000434061ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000434061ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000435046ENST00000360359EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000435046ENST00000535627EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+
5CDS-intronENST00000435046ENST00000470698EIF4G1chr3

184053139

+ANKS1Achr6

34977682

+

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FusionProtFeatures for EIF4G1_ANKS1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G1

Q04637

ANKS1A

Q92625

Regulator of different signaling pathways. RegulatesEPHA8 receptor tyrosine kinase signaling to control cell migrationand neurite retraction (By similarity). {ECO:0000250,ECO:0000269|PubMed:17875921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4G1_ANKS1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G1_ANKS1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF4G1EIF4A2, NELFCD, EIF4A1, GABARAPL2, MAGEA6, MKNK2, PDCD4, EIF4E, EIF3B, EIF3A, EIF3I, MKNK1, NCBP1, PABPC1, HNRNPD, USP10, EIF3H, EIF3F, USP3, G3BP1, UBE3A, CENPU, RAD21, SIRT7, ISG15, CUL3, TRAF2, EIF4G2, EIF4B, EIF4G3, SF3A3, FTL, RAB31, ESR1, FN1, VCAM1, HTRA2, ZFYVE9, ITGA4, BRCA1, GK, TARDBP, AIMP1, AIMP2, EEF1E1, IQGAP1, PSMB8, PTBP1, QARS, LGR4, POLDIP3, CUL7, CCDC8, MAMDC2, PSMC3, UNK, DCTN4, KIAA0020, NAT10, PUS7, SF3A1, SF3A2, SKIV2L2, FBL, NUP50, PABPC4, POLE, SF3B3, TNKS1BP1, NTRK1, HERC2, SRPK2, CLCN2, HSPA5, TOR1AIP1, SGTB, MRPL9, ACTR5, CNTROB, FOXB1, FOXL1, MCM2, RC3H1, SLBP, CDH1, GCHFR, NFATC2IP, EMILIN1, CYLD, DLD, DLST, PDHA1, TRIM25ANKS1AYWHAG, SFN, UBC, EPHA8, EGFR, ERBB2, ERBB4, BAG3, YWHAB, DNPEP, PACSIN2, PTPN12, TRIM47, DEF6, PIK3R3, ARHGAP10, DOK3, KLF15, NHLRC2, TRIT1, RANBP3, RB1, SMARCD1, RIN1, DAB2IP, HIF1AN, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4G1_ANKS1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4G1_ANKS1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF4G1C3280271PARKINSON DISEASE 181UNIPROT
TgeneANKS1AC1956346Coronary Artery Disease1CTD_human