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Fusion gene ID: 11320 |
FusionGeneSummary for EIF4ENIF1_C22orf24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4ENIF1_C22orf24 | Fusion gene ID: 11320 | Hgene | Tgene | Gene symbol | EIF4ENIF1 | C22orf24 | Gene ID | 56478 | 25775 |
| Gene name | eukaryotic translation initiation factor 4E nuclear import factor 1 | chromosome 22 open reading frame 24 | |
| Synonyms | 4E-T|Clast4 | HSN44A4A | |
| Cytomap | 22q12.2 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 4E transporter2610509L04RikeIF4E transporter | uncharacterized protein C22orf24 | |
| Modification date | 20180522 | 20180329 | |
| UniProtAcc | Q9NRA8 | Q9Y442 | |
| Ensembl transtripts involved in fusion gene | ENST00000344710, ENST00000397525, ENST00000330125, ENST00000397523, ENST00000382180, ENST00000441289, | ENST00000248984, ENST00000543051, ENST00000486651, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: EIF4ENIF1 [Title/Abstract] AND C22orf24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XK-AAIV-01A | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344710 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000344710 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| 5CDS-5UTR | ENST00000344710 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000397525 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000397525 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| 5CDS-5UTR | ENST00000397525 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000330125 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000330125 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| 5CDS-5UTR | ENST00000330125 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000397523 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| In-frame | ENST00000397523 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| 5CDS-5UTR | ENST00000397523 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-3CDS | ENST00000382180 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-3CDS | ENST00000382180 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-5UTR | ENST00000382180 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-3CDS | ENST00000441289 | ENST00000248984 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-3CDS | ENST00000441289 | ENST00000543051 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
| intron-5UTR | ENST00000441289 | ENST00000486651 | EIF4ENIF1 | chr22 | 31867830 | - | C22orf24 | chr22 | 32330435 | - |
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FusionProtFeatures for EIF4ENIF1_C22orf24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4ENIF1 | C22orf24 |
| Nucleoplasmic shuttling protein, which inhibitstranslation initiation. Mediates the nuclear import of EIF4E by apiggy-back mechanism. {ECO:0000269|PubMed:10856257}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000330125 | - | 3 | 19 | 30_36 | 56 | 986 | Region | Note=EIF4E-binding |
| Hgene | EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000344710 | - | 3 | 17 | 30_36 | 56 | 812 | Region | Note=EIF4E-binding |
| Hgene | EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000397525 | - | 3 | 19 | 30_36 | 56 | 986 | Region | Note=EIF4E-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000330125 | - | 3 | 19 | 148_210 | 56 | 986 | Compositional bias | Note=Arg-rich |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000344710 | - | 3 | 17 | 148_210 | 56 | 812 | Compositional bias | Note=Arg-rich |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000397525 | - | 3 | 19 | 148_210 | 56 | 986 | Compositional bias | Note=Arg-rich |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000330125 | - | 3 | 19 | 195_211 | 56 | 986 | Motif | Note=Nuclear localization signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000330125 | - | 3 | 19 | 438_447 | 56 | 986 | Motif | Note=Nuclear export signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000330125 | - | 3 | 19 | 613_638 | 56 | 986 | Motif | Note=Nuclear export signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000344710 | - | 3 | 17 | 195_211 | 56 | 812 | Motif | Note=Nuclear localization signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000344710 | - | 3 | 17 | 438_447 | 56 | 812 | Motif | Note=Nuclear export signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000344710 | - | 3 | 17 | 613_638 | 56 | 812 | Motif | Note=Nuclear export signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000397525 | - | 3 | 19 | 195_211 | 56 | 986 | Motif | Note=Nuclear localization signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000397525 | - | 3 | 19 | 438_447 | 56 | 986 | Motif | Note=Nuclear export signal |
| Hgene | >EIF4ENIF1 | chr22:31867830 | chr22:32330435 | ENST00000397525 | - | 3 | 19 | 613_638 | 56 | 986 | Motif | Note=Nuclear export signal |
| Tgene | C22orf24 | chr22:31867830 | chr22:32330435 | ENST00000248984 | - | 1 | 3 | 27_47 | 50 | 161 | Transmembrane | Helical |
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FusionGeneSequence for EIF4ENIF1_C22orf24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_167aa MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDRFQYQPDFFWKDPLASRWSGHLPXPTELDFSLSS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_502nt ATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTAT ACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTAT CAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCA ATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTG CTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_1257nt GAGACAGCCCAAGCCGGTCGGGGTGGGGGCGCGAGAGCGAAGGCTGCGGGGAGCGGCGCTGGGACCGGTGCGGGCAGCGGGGAGGGGAGC GGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTG AAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATA TAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGG ATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTAT GCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATG ACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCT TACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGG AAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCA CTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATA AACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCA GTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGA GCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAG >In-frame_EIF4ENIF1_ENST00000344710_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_767nt GAGACAGCCCAAGCCGGTCGGGGTGGGGGCGCGAGAGCGAAGGCTGCGGGGAGCGGCGCTGGGACCGGTGCGGGCAGCGGGGAGGGGAGC GGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTG AAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATA TAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGG ATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTAT GCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATG ACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCT TACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGG >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_1323nt GCGGGCGCCGGGGCGCCCGCAGGGGGTGGGCAGGGGCGCGAGGCCCGCAAGGCGGCCGGCGGGTAGCCGGCGGGCTGGCTGGCGGGGACC GAGCCGCCGGGCCGGGGAGGACGGCTGCGGGCCTGCGCTAGCTCCAGCTTGAAGCGCCCGGGCCGGGAGATTCGGCCTCCCTCCTCCCTG CGGCCGGCCGCCCCTCAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCC TTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAAC AGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTG GGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAG CCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCA GGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAG TCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAA GCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCACTGCGCAAAATGCAGCCTCTAAGA GCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATAAACCATAAAGCGCCCAACAGATGA GCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCAGTGGGACAAGAAGACTGCTGACCA AGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGAGCAGAGCACTGGTGCCAGCCCAAC CTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAGCCTCAGTCCCCCTTATCTGTGAAA >In-frame_EIF4ENIF1_ENST00000397525_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_833nt GCGGGCGCCGGGGCGCCCGCAGGGGGTGGGCAGGGGCGCGAGGCCCGCAAGGCGGCCGGCGGGTAGCCGGCGGGCTGGCTGGCGGGGACC GAGCCGCCGGGCCGGGGAGGACGGCTGCGGGCCTGCGCTAGCTCCAGCTTGAAGCGCCCGGGCCGGGAGATTCGGCCTCCCTCCTCCCTG CGGCCGGCCGCCCCTCAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCC TTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAAC AGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTG GGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAG CCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCA GGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAG TCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAA >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_1174nt GGGGAGCGGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGT ATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTC TTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTT TGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCA CCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTG CCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGC CACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTC ACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTG GCCTTCACTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGG CTTTATAAACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACAT GCCTGCAGTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAG CGGGAGAGCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCAC TGCTGAGCCTCAGTCCCCCTTATCTGTGAAATGGGAATGATGCTTTCCTTGTAGCACTGCTGTGAAGATTCAATGAAACGAGTGATGCCG >In-frame_EIF4ENIF1_ENST00000330125_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_684nt GGGGAGCGGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGT ATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTC TTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTT TGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCA CCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTG CCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGC CACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTC >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000248984_chr22_32330435_-_1126nt GTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCT CCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTT TCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCC ACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCT CGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCT GAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTC CTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGAC GTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCACTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCA GAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATAAACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCAT TTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCAGTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATC AATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGAGCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGG TTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAGCCTCAGTCCCCCTTATCTGTGAAATGGGAATGATGCTTTCC >In-frame_EIF4ENIF1_ENST00000397523_chr22_31867830_-_C22orf24_ENST00000543051_chr22_32330435_-_636nt GTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCT CCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTT TCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCC ACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCT CGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCT GAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTC CTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGAC |
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FusionGenePPI for EIF4ENIF1_C22orf24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF4ENIF1 | EIF4E2, EIF4E, MYC, BCL6, ATXN1, CDK6, FDPS, LATS2, SAV1, AURKB, CEP250, DDX6, HNRNPF, KRT19, OIP5, DEF6, TTC19, FANCL, DTX2, EFHC1, MGAT5B, TXLNA, FBXW11, EWSR1, SSX2IP, OFD1, B9D2, CEP128, FBF1, NINL, NIN, ODF2, RPGRIP1L, SCLT1, XPO1, PRKCI, SEC16A, CERK, CDC16, KLHDC3, HIF1AN, ASB3, KIAA0430, HELZ, NISCH, SOWAHA, PAN2, PCGF5, CTBP1, CREBBP, KIAA1671, PCGF3, ARID3A, ERF, POM121C, NUP50, C15orf39 | C22orf24 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4ENIF1_C22orf24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4ENIF1_C22orf24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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