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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11318

FusionGeneSummary for EIF4EBP2_EIF4EBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4EBP2_EIF4EBP2
Fusion gene ID: 11318
HgeneTgene
Gene symbol

EIF4EBP2

EIF4EBP2

Gene ID

1979

1979

Gene nameeukaryotic translation initiation factor 4E binding protein 2eukaryotic translation initiation factor 4E binding protein 2
Synonyms4EBP2|PHASII4EBP2|PHASII
Cytomap

10q22.1

10q22.1

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4E-binding protein 24E-BP2eIF4E-binding protein 2phosphorylated, heat and acid stable regulated by insulin protein IIeukaryotic translation initiation factor 4E-binding protein 24E-BP2eIF4E-binding protein 2phosphorylated, heat and acid stable regulated by insulin protein II
Modification date2018052320180523
UniProtAcc

Q13542

Q13542

Ensembl transtripts involved in fusion geneENST00000373218, ENST00000373218, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 1=25
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF4EBP2 [Title/Abstract] AND EIF4EBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA278954EIF4EBP2chr10

72187809

+EIF4EBP2chr10

72187684

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000373218ENST00000373218EIF4EBP2chr10

72187809

+EIF4EBP2chr10

72187684

-

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FusionProtFeatures for EIF4EBP2_EIF4EBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4EBP2

Q13542

EIF4EBP2

Q13542

Repressor of translation initiation involved in synapticplasticity, learning and memory formation (By similarity).Regulates EIF4E activity by preventing its assembly into the eIF4Fcomplex: hypophosphorylated form of EIF4EBP2 competes withEIF4G1/EIF4G3 and strongly binds to EIF4E, leading to represstranslation. In contrast, hyperphosphorylated form dissociatesfrom EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E,leading to initiation of translation (PubMed:25533957). EIF4EBP2is enriched in brain and acts as a regulator of synapse activityand neuronal stem cell renewal via its ability to represstranslation initiation (By similarity). Mediates the regulation ofprotein translation by hormones, growth factors and other stimulithat signal through the MAP kinase and mTORC1 pathways (Bysimilarity). {ECO:0000250|UniProtKB:P70445,ECO:0000269|PubMed:25533957}. Repressor of translation initiation involved in synapticplasticity, learning and memory formation (By similarity).Regulates EIF4E activity by preventing its assembly into the eIF4Fcomplex: hypophosphorylated form of EIF4EBP2 competes withEIF4G1/EIF4G3 and strongly binds to EIF4E, leading to represstranslation. In contrast, hyperphosphorylated form dissociatesfrom EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E,leading to initiation of translation (PubMed:25533957). EIF4EBP2is enriched in brain and acts as a regulator of synapse activityand neuronal stem cell renewal via its ability to represstranslation initiation (By similarity). Mediates the regulation ofprotein translation by hormones, growth factors and other stimulithat signal through the MAP kinase and mTORC1 pathways (Bysimilarity). {ECO:0000250|UniProtKB:P70445,ECO:0000269|PubMed:25533957}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4EBP2_EIF4EBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4EBP2_EIF4EBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4EBP2_EIF4EBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4EBP2_EIF4EBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource