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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11313

FusionGeneSummary for EIF4E3_FCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4E3_FCN3
Fusion gene ID: 11313
HgeneTgene
Gene symbol

EIF4E3

FCN3

Gene ID

317649

8547

Gene nameeukaryotic translation initiation factor 4E family member 3ficolin 3
SynonymseIF-4E3|eIF4E-3FCNH|HAKA1
Cytomap

3p13

1p36.11

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4E type 3ficolin-3H-ficolincollagen/fibrinogen domain-containing lectin 3 p35collagen/fibrinogen domain-containing protein 3ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Modification date2018051920180519
UniProtAcc

Q8N5X7

O75636

Ensembl transtripts involved in fusion geneENST00000425534, ENST00000389826, 
ENST00000448225, ENST00000295612, 
ENST00000468147, ENST00000421769, 
ENST00000270879, ENST00000354982, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 31
** MAII scorelog2(3/4*10)=2.90689059560852log2(1/1*10)=3.32192809488736
Context

PubMed: EIF4E3 [Title/Abstract] AND FCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFCN3

GO:0001867

complement activation, lectin pathway

11907111

TgeneFCN3

GO:0006956

complement activation

22851708

TgeneFCN3

GO:0043654

recognition of apoptotic cell

15804047

TgeneFCN3

GO:0051607

defense response to virus

22851708

TgeneFCN3

GO:1902679

negative regulation of RNA biosynthetic process

22851708


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D88587EIF4E3chr3

71731514

+FCN3chr1

27701313

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000425534ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000425534ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000389826ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000389826ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000448225ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000448225ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000295612ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000295612ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000468147ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000468147ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000421769ENST00000270879EIF4E3chr3

71731514

+FCN3chr1

27701313

-
intron-3CDSENST00000421769ENST00000354982EIF4E3chr3

71731514

+FCN3chr1

27701313

-

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FusionProtFeatures for EIF4E3_FCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4E3

Q8N5X7

FCN3

O75636

Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis. May act as an inhibitor of EIF4E1 activity (Bysimilarity). {ECO:0000250}. May function in innate immunity through activation ofthe lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, asmono/oligosaccharide and lipopolysaccharides from S.typhimuriumand S.minnesota. {ECO:0000269|PubMed:11907111,ECO:0000269|PubMed:17215869}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4E3_FCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4E3_FCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4E3_FCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFCN3O75636DB01593ZincFicolin-3small moleculeapproved|investigational

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RelatedDiseases for EIF4E3_FCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF4E3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFCN3C0021051Immunologic Deficiency Syndromes1CTD_human;HPO