FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 11312

FusionGeneSummary for EIF4E3_EIF4E3

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4E3_EIF4E3
Fusion gene ID: 11312
HgeneTgene
Gene symbol

EIF4E3

EIF4E3

Gene ID

317649

317649

Gene nameeukaryotic translation initiation factor 4E family member 3eukaryotic translation initiation factor 4E family member 3
SynonymseIF-4E3|eIF4E-3eIF-4E3|eIF4E-3
Cytomap

3p13

3p13

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4E type 3eukaryotic translation initiation factor 4E type 3
Modification date2018051920180519
UniProtAcc

Q8N5X7

Q8N5X7

Ensembl transtripts involved in fusion geneENST00000425534, ENST00000389826, 
ENST00000448225, ENST00000295612, 
ENST00000468147, ENST00000421769, 
ENST00000425534, ENST00000389826, 
ENST00000448225, ENST00000295612, 
ENST00000468147, ENST00000421769, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 2 X 4=24
# samples 36
** MAII scorelog2(3/4*10)=2.90689059560852log2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF4E3 [Title/Abstract] AND EIF4E3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF955589EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
ChiTaRS3.1BF955653EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000425534ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000425534ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000425534ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000425534ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000425534ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000425534ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-3CDSENST00000389826ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000389826ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000389826ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000389826ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000389826ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000389826ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-3CDSENST00000448225ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000448225ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000448225ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000448225ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000448225ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000448225ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-3CDSENST00000295612ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000295612ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000295612ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000295612ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000295612ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000295612ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-3CDSENST00000468147ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000468147ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000468147ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000468147ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000468147ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000468147ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-3CDSENST00000421769ENST00000425534EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000421769ENST00000389826EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000421769ENST00000448225EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000421769ENST00000295612EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000421769ENST00000468147EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-
intron-5UTRENST00000421769ENST00000421769EIF4E3chr3

71733723

-EIF4E3chr3

71759635

-

Top

FusionProtFeatures for EIF4E3_EIF4E3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4E3

Q8N5X7

EIF4E3

Q8N5X7

Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis. May act as an inhibitor of EIF4E1 activity (Bysimilarity). {ECO:0000250}. Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis. May act as an inhibitor of EIF4E1 activity (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for EIF4E3_EIF4E3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for EIF4E3_EIF4E3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for EIF4E3_EIF4E3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for EIF4E3_EIF4E3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF4E3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneEIF4E3C0023893Liver Cirrhosis, Experimental1CTD_human