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Fusion gene ID: 11309 |
FusionGeneSummary for EIF4E2_CREBBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4E2_CREBBP | Fusion gene ID: 11309 | Hgene | Tgene | Gene symbol | EIF4E2 | CREBBP | Gene ID | 9470 | 1387 |
| Gene name | eukaryotic translation initiation factor 4E family member 2 | CREB binding protein | |
| Synonyms | 4E-LP|4EHP|EIF4EL3|IF4e|h4EHP | CBP|KAT3A|RSTS|RSTS1 | |
| Cytomap | 2q37.1 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 4E type 2eIF-4E type 2eIF4E-like cap-binding proteineIF4E-like protein 4E-LPeukaryotic translation initiation factor 4E homologous proteineukaryotic translation initiation factor 4E-like 3mRNA cap-binding pro | CREB-binding protein | |
| Modification date | 20180520 | 20180522 | |
| UniProtAcc | O60573 | Q92793 | |
| Ensembl transtripts involved in fusion gene | ENST00000409514, ENST00000409098, ENST00000409394, ENST00000258416, ENST00000409495, ENST00000409167, ENST00000409322, ENST00000479834, | ENST00000262367, ENST00000382070, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 17 X 3=408 |
| # samples | 3 | 18 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/408*10)=-1.18057224564182 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF4E2 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
| Tgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
| Tgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24939902 |
| Tgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
| Tgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Tgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
| Tgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA778521 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000409514 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409514 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409098 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409098 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409394 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409394 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000258416 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000258416 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409495 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409495 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409167 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409167 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409322 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| Frame-shift | ENST00000409322 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| 3UTR-3CDS | ENST00000479834 | ENST00000262367 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
| 3UTR-3CDS | ENST00000479834 | ENST00000382070 | EIF4E2 | chr2 | 233421174 | + | CREBBP | chr16 | 3832912 | - |
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FusionProtFeatures for EIF4E2_CREBBP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4E2 | CREBBP |
| Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation (PubMed:9582349,PubMed:17368478, PubMed:25624349). Acts as a repressor oftranslation initiation (PubMed:22751931). In contrast to EIF4E, itis unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggestingthat it acts by competing with EIF4E and block assembly of eIF4Fat the cap (By similarity). {ECO:0000250|UniProtKB:Q8BMB3,ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931,ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:9582349}. | Acetylates histones, giving a specific tag fortranscriptional activation. Also acetylates non-histone proteins,like NCOA3 and FOXO1. Binds specifically to phosphorylated CREBand enhances its transcriptional activity toward cAMP-responsivegenes. Acts as a coactivator of ALX1. Acts as a circadiantranscriptional coactivator which enhances the activity of thecircadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotesremoval of chromatin-bound PCNA and its degradation duringnucleotide excision repair (NER) (PubMed:24939902).{ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767,ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221,ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4E2_CREBBP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF4E2_CREBBP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4E2_CREBBP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4E2_CREBBP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CREBBP | C0035934 | Rubinstein-Taybi Syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | CREBBP | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | CREBBP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | CREBBP | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | CREBBP | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | CREBBP | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Tgene | CREBBP | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CREBBP | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | CREBBP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | CREBBP | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | CREBBP | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | CREBBP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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