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Fusion gene ID: 11304 |
FusionGeneSummary for EIF4A2_KNG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4A2_KNG1 | Fusion gene ID: 11304 | Hgene | Tgene | Gene symbol | EIF4A2 | KNG1 | Gene ID | 1974 | 3827 |
| Gene name | eukaryotic translation initiation factor 4A2 | kininogen 1 | |
| Synonyms | BM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-II | BDK|BK|HMWK|KNG | |
| Cytomap | 3q27.3 | 3q27.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2 | kininogen-1alpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenwilliams-Fitzgerald-Flaujeac factor | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q14240 | P01042 | |
| Ensembl transtripts involved in fusion gene | ENST00000323963, ENST00000440191, ENST00000356531, | ENST00000287611, ENST00000265023, ENST00000447445, | |
| Fusion gene scores | * DoF score | 6 X 7 X 2=84 | 4 X 4 X 4=64 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF4A2 [Title/Abstract] AND KNG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF4A2 | GO:1900260 | negative regulation of RNA-directed 5'-3' RNA polymerase activity | 11922617 |
| Tgene | KNG1 | GO:0007162 | negative regulation of cell adhesion | 11970955 |
| Tgene | KNG1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 16014619 |
| Tgene | KNG1 | GO:0030195 | negative regulation of blood coagulation | 11970955 |
| Tgene | KNG1 | GO:0045861 | negative regulation of proteolysis | 3488317 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BC-A10Y-01A | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000323963 | ENST00000287611 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000323963 | ENST00000265023 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000323963 | ENST00000447445 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| Frame-shift | ENST00000440191 | ENST00000287611 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000440191 | ENST00000265023 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000440191 | ENST00000447445 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| Frame-shift | ENST00000356531 | ENST00000287611 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000356531 | ENST00000265023 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
| 5CDS-intron | ENST00000356531 | ENST00000447445 | EIF4A2 | chr3 | 186504062 | + | KNG1 | chr3 | 186461494 | + |
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FusionProtFeatures for EIF4A2_KNG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4A2 | KNG1 |
| ATP-dependent RNA helicase which is a subunit of theeIF4F complex involved in cap recognition and is required for mRNAbinding to ribosome. In the current model of translationinitiation, eIF4A unwinds RNA secondary structures in the 5'-UTRof mRNAs which is necessary to allow efficient binding of thesmall ribosomal subunit, and subsequent scanning for the initiatorcodon. | (1) Kininogens are inhibitors of thiol proteases; (2)HMW-kininogen plays an important role in blood coagulation byhelping to position optimally prekallikrein and factor XI next tofactor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptidebradykinin that is released from HMW-kininogen shows a variety ofphysiological effects: (4A) influence in smooth musclecontraction, (4B) induction of hypotension, (4C) natriuresis anddiuresis, (4D) decrease in blood glucose level, (4E) it is amediator of inflammation and causes (4E1) increase in vascularpermeability, (4E2) stimulation of nociceptors (4E3) release ofother mediators of inflammation (e.g. prostaglandins), (4F) it hasa cardioprotective effect (directly via bradykinin action,indirectly via endothelium-derived relaxing factor action); (5)LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in bloodclotting. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4A2_KNG1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF4A2_KNG1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF4A2 | EIF4G1, EIF3A, PDCD4, P4HB, EIF3L, EIF3D, EIF3H, MYO1B, EIF3M, PABPC1, EIF3K, EIF4G3, DDX3X, EIF4G2, EIF4E, CD2BP2, SPAG9, AKAP17A, ATRX, VAC14, ALPI, PTPRS, RPS29, TPM3, CMBL, EIF3F, RPAP2, CD4, NEK2, TK1, PFDN1, EIF4A1, DDX39B, BRCA1, ECT2, VCP, CD81, BAG3, EIF4A2, MDFI, IPO11, DPPA4, TRIM36, TRIM39, SSX2IP, PIH1D2, SLC16A9, HNRNPA1, HSPB1, UNK, AIMP1, CETN2, RPSA, EIF4A3, LAGE3, HSPB2, GOLGA2, CRY1, CRY2, MCM2, CDC5L, DUSP28, CYLD, TRIM25, MCPH1 | KNG1 | PLAUR, KLKB1, F11, KRT1, VTN, FTL, PLG, ELANE, ITGB2, CD93, COPS6, ECE1, GDPD1, TUBB8, ANAPC1, CAPN1, CTSO, P3H4, CTSV, ANAPC5, PPP2CA, LEPREL2, TCTN1, CAPNS1, HLA-DPB1, VHL, ZNF562, MEP1A, PPP2R2C, SNX27, MRC2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4A2_KNG1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | KNG1 | P01042 | DB01593 | Zinc | Kininogen-1 | small molecule | approved|investigational |
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RelatedDiseases for EIF4A2_KNG1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EIF4A2 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| Hgene | EIF4A2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | EIF4A2 | C0394996 | Acute alcoholic intoxication | 1 | PSYGENET |
| Tgene | KNG1 | C0020429 | Hyperalgesia | 17 | CTD_human |
| Tgene | KNG1 | C0020649 | Hypotension | 9 | CTD_human |
| Tgene | KNG1 | C0030193 | Pain | 6 | CTD_human |
| Tgene | KNG1 | C0011609 | Drug Eruptions | 2 | CTD_human |
| Tgene | KNG1 | C0027055 | Myocardial Reperfusion Injury | 2 | CTD_human |
| Tgene | KNG1 | C2609414 | Acute kidney injury | 2 | CTD_human |
| Tgene | KNG1 | C0002792 | anaphylaxis | 1 | CTD_human |
| Tgene | KNG1 | C0003811 | Cardiac Arrhythmia | 1 | CTD_human |
| Tgene | KNG1 | C0010200 | Coughing | 1 | CTD_human |
| Tgene | KNG1 | C0013604 | Edema | 1 | CTD_human |
| Tgene | KNG1 | C0015379 | Extravasation of Diagnostic and Therapeutic Materials | 1 | CTD_human |
| Tgene | KNG1 | C0019243 | Angioedemas, Hereditary | 1 | CTD_human |
| Tgene | KNG1 | C0020452 | Hyperemia | 1 | CTD_human |
| Tgene | KNG1 | C0020453 | Hyperesthesia | 1 | CTD_human |
| Tgene | KNG1 | C0020517 | Hypersensitivity | 1 | CTD_human |
| Tgene | KNG1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | KNG1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | KNG1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | KNG1 | C0039231 | Tachycardia | 1 | CTD_human |
| Tgene | KNG1 | C0428977 | Bradycardia | 1 | CTD_human |
| Tgene | KNG1 | C2931758 | Acquired angioedema | 1 | CTD_human |
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