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Fusion gene ID: 11301 |
FusionGeneSummary for EIF4A1_PHOSPHO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4A1_PHOSPHO1 | Fusion gene ID: 11301 | Hgene | Tgene | Gene symbol | EIF4A1 | PHOSPHO1 | Gene ID | 1973 | 162466 |
| Gene name | eukaryotic translation initiation factor 4A1 | phosphoethanolamine/phosphocholine phosphatase | |
| Synonyms | DDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I | - | |
| Cytomap | 17p13.1 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A | phosphoethanolamine/phosphocholine phosphatasephosphatase, orphan 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P60842 | Q8TCT1 | |
| Ensembl transtripts involved in fusion gene | ENST00000380512, ENST00000293831, ENST00000577269, ENST00000582746, ENST00000581808, | ENST00000310544, ENST00000413580, ENST00000514112, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 3 X 2=12 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EIF4A1 [Title/Abstract] AND PHOSPHO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-1034-02B | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| TCGA | RV | GBM | TCGA-14-1034-01A | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000380512 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000380512 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000380512 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-intron | ENST00000293831 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000293831 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000293831 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-intron | ENST00000577269 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000577269 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000577269 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-intron | ENST00000582746 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000582746 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| 5CDS-5UTR | ENST00000582746 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| intron-intron | ENST00000581808 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| intron-5UTR | ENST00000581808 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| intron-5UTR | ENST00000581808 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302493 | - |
| Frame-shift | ENST00000380512 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| In-frame | ENST00000380512 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| In-frame | ENST00000380512 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000293831 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000293831 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000293831 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000577269 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000577269 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000577269 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000582746 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000582746 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| Frame-shift | ENST00000582746 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| intron-3CDS | ENST00000581808 | ENST00000310544 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| intron-3CDS | ENST00000581808 | ENST00000413580 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
| intron-3CDS | ENST00000581808 | ENST00000514112 | EIF4A1 | chr17 | 7478576 | + | PHOSPHO1 | chr17 | 47302366 | - |
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FusionProtFeatures for EIF4A1_PHOSPHO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4A1 | PHOSPHO1 |
| ATP-dependent RNA helicase which is a subunit of theeIF4F complex involved in cap recognition and is required for mRNAbinding to ribosome. In the current model of translationinitiation, eIF4A unwinds RNA secondary structures in the 5'-UTRof mRNAs which is necessary to allow efficient binding of thesmall ribosomal subunit, and subsequent scanning for the initiatorcodon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. | Phosphatase that has a high activity towardphosphoethanolamine (PEA) and phosphocholine (PCho). Involved inthe generation of inorganic phosphate for bone mineralization. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4A1_PHOSPHO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000413580_chr17_47302366_-_232aa MEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVL APTRELAQQVRVASIPSFRADLGMMSIIQGPEKSSLITTLGGRHGCPNTLETCWVNXKLFLTQTXPLLPPPISXVKWESCWVKPGWLGKF >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000514112_chr17_47302366_-_232aa MEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVL APTRELAQQVRVASIPSFRADLGMMSIIQGPEKSSLITTLGGRHGCPNTLETCWVNXKLFLTQTXPLLPPPISXVKWESCWVKPGWLGKF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000413580_chr17_47302366_-_697nt ATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTCTCGGAGTCCCTTCTCCGTGGC ATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTTGTATCAAGGGTTATGATGTGATTGCTCAAGCC CAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTA GCACCCACTCGAGAATTGGCTCAGCAGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGATGAGTATAATCCAAGGA CCAGAGAAGTCTTCTCTGATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGTTAATTAAAAGCTATTT CTTACCCAAACGTAACCATTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGGCTGGCTGGGCAAGTTT GACTGTGTTCTGAATAAGCACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCAGAGCAGATGGACAGTC >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000514112_chr17_47302366_-_697nt ATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTCTCGGAGTCCCTTCTCCGTGGC ATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTTGTATCAAGGGTTATGATGTGATTGCTCAAGCC CAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTA GCACCCACTCGAGAATTGGCTCAGCAGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGATGAGTATAATCCAAGGA CCAGAGAAGTCTTCTCTGATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGTTAATTAAAAGCTATTT CTTACCCAAACGTAACCATTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGGCTGGCTGGGCAAGTTT GACTGTGTTCTGAATAAGCACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCAGAGCAGATGGACAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000413580_chr17_47302366_-_6745nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGGACTGAGCCTAACCCCGAGGAGCGGCCGCGTGAGGCACCAGGAGCCCACCCGGCGCCGGGCGGGCGG GTCCATTTTGCCGCACAAGCCGGGCTATTGGCAAACTGCGGATGGGCAGGTCCACCTTCCTTCGGGGGTGAGCGGCCTGAGATCCAGAGA CAATGGCCCCGATGGGATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTCTCGGA GTCCCTTCTCCGTGGCATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTTGTATCAAGGGTTATGA TGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCAC CCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGAT GAGTATAATCCAAGGACCAGAGAAGTCTTCTCTGATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGT TAATTAAAAGCTATTTCTTACCCAAACGTAACCATTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGG CTGGCTGGGCAAGTTTGACTGTGTTCTGAATAAGCACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCA GAGCAGATGGACAGTCCTTTTCACCCTTGCTTAATAGCCAGAGCTGTTTCATGCCTGGGGCACACACAATTCTAATGCTGGACGCGGCTC CGGCTCCGGCTCCGGCTCCCGGGCATTTAAAGGGGACGCGGCGGCTGCCCGGGGGGGATGAGGGGCAAGTGGAGGGGACGGCTCAGACGC ACATCATCCTCAGTCCCTCGGGACTGGAGGGACTCGTGAGCCGGAGCCCAGAAATCCGGGGGTGGATAAGACACCGCGTCCCCTCCAATT CCCGTAAGCACCCCTTGCTCCATCCTGCGCCCCAATACCTCAGCTAGCCCCCTTCCCCACTTCTTACACTCCAAACTCAGCCGGGACAGA CCTCTGCTGCCGCCGCCCCCACGTGAGTCCTGGGCTCCGGGAGATAGGGGAGGGCTGGGGTCCCGGCGCGGGGTGGGGGCTGTGGAGTTT GAAGGCGCTCCTTCACGCGCGTGGCACTGGGGGAGTTCTGGAGCTCAGGAGTGAGTCCCCTTCTCTCTCCTACCCAGGAACATAGTGCTG GGGTATCCCTCCGTCCCCGACTCTGACAAAGCCAAGGAATTGGTGTCCCCTTGCTCCCTGCCACCCACAATACCCCTCCCCGAGCCGCGC ACCCCCCGCCCGCATTGGAGCCCAGCGCCCGCCAGCCGGGGGTGCGCCAGAGTGCTGGCTTCCTAGTCACCTCTAAAAATATCTCTCCCC CAACCCTACCGGCAGCTGCCACCTCCCTGCCCCTGCCCCTGCCCCTAGGATCCCCTCCCAGCTTGTCCTCCCACCCAGGGAGTGCCCAGA GGTGACTGCTAGACCCAGACGCCTCACTGGCACCAGGGCGCAGGGCCACCACCGCCAGCTGGTCAGGACCGCAAGCTCCCTGCCCACTGG AGTCTCCAGGGCCAAGGGGGGAGCTCCAGCTGCAATTCTCCCAAGAGGCGCCAGAGACTCCTGAGTTCTAATCGCGGTTCCGATGCTGTG TGACCCCTAGGATGTTAGCCTGACCTCTCTGGGCCTCTGTTTTTCCTATCTGCTGCTCGGGCGTGGTGAGCAAGGAAGATGGTCATGTTT GGGAGCACTGTCTGGGAAAGGGAGGGAATTCTAGCTTAGTTGTTGGATCTGATTTCTAGTGATTGATACAAGGAGACTTGTTTTTGGACA GAGAGGGCTTGTTACTGTGGTCTTTCTGGAGTCCTCGCCTCCCCATCCTCATTCTGCACATTTCCTTTGGAAAACTATCCCAAAACTTTT CTAGGAACTCCATCTGCCCAGTAAGAGGGGAATTTGAAACTTAGGGCCTGTATCAGAGAGGGGCCTGTTTCCCTCCCACCCCCTTCCCAC AGATTTAATCTAAGAGCATTTGTGTGAAAGGCGGGAGAAGCAGGCAGGGATCTGTGACCCGGTGCAGAATTAAGGAGGCAGGCACTGCTT TTAGGTGGGACTAGAATATGGACTCCCTGCAACCCCCCAGAAGCCCTTCTCCCTGCTCTGGCCTGTGAGAGAAGCTCAGATCCTGCCCCC TACTCTGAGGGACTCTGTTTGGTGACCACAAAAGGATTTGATGACTCAGAACAAAGGTGTCAGAGGTGAGAGACCTTTTGGAGCATCACA GGAGCCAAATTCCAACTGGGGAAGGGGTTCCTCTGACTCCTGTGGGGTGGGGACGAGGTGTCACAGCATGGCCTTCTCAGTTTTCTGGGG AAGAAACCCAAGATGCCTGACTTTCTGCCTTGGAGACTGAAAGAAACAAGGGCAACTCACCAAACAATAAGTGTTTAACTGAATCCCCTA GATACTATTATTAGCAGAAAAATGTAACTGTATTTTATGATGAGAAATGAGGAGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGG GATGGGGTTACTCCCTCTGTCACCCAGGCTGGAGTGCAGTGGTACCATTACAGCTCACTGCAACCTCTGTCTCCTGGGTTTAAGTGATCC TCGTGCCTCAGCCTCCCAAGTAGCTGGGACTATGGGCACAAGCTACCATACCCAGCTAATTTTTTTTTTTTTTTTTTTTTTTGAGACGGA GTCTCGCTGTCGCCCAGGCTGGAATGCAATGGCGCAATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCA GCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAG CCAGGATGGTCTCGATCTTCTGACCTCGTGATTCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCGGC CTTAATTTTTGTTTTTAAAGAGACAGGGTTTTGCCATGTCACCCAGTCTGGTCTCAAACTCCTAGACTTAAGTGATCTGCCTGCCTCGCC TCCCAAAGTGTTGGGATTACAGGCTTAAGCCACCCTGCCTGGCTGAAAAAATGAGAAGTTTTGACCATAATTAATGATCAATAGAATAGA AAAAAGGAAGGAAGGAAGGAAGGAAGGAAGGAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAGAGAGAC AGGAAGGAAGGAAGGGCAAAGTAATGAGACCCTTCTCTATAGGATGAAAGCTGGTCTCTGGGTAGCTGTTGGTGACCCCTTGGAATCTTT GTATCTACCCCTTGCTTCTCCAGATGCTGCATGTTTGCTTTTACAAGGGGAGTGGCATCCCTGACCTTTCTCTTATAAATCGCCTGGCTG AGGTTGGACATGTGATATCAGCTGGGAATCTGGAAGGTTGGAAGTCCCTCCAGATAGGGACTGGGGACAGCTCCAACCCATGCCATTTCC TTGTCCCTCATGCAACCCTCCCCTTCTCTCCCACCTCCTCCTTGACCTGTCTTCTCTCCCATCCCTCACCCTCTCTTTGCCCACTGCTTC ATTCAGCTTTGACCACCTCTCCTAATTCCTAGATTAGAAGTTCTTGGAAAAAACTGAGAGCCGCATTCCATCCCTGCAGAAGGATTTAAC ACATGTGTGGTCTGGTTGTTGTGAGGGAGGGAGTACCGCAAGATGGATATTGCTAGAGCCTGTACCCTGCTCCTGGGATGTCCCCGTCTC TGTCCTGGGGCGATTGCTTCTCCCTCCTGAATAGTCAGGGGAGAGTGTCACCTTGACAGAGGGGTTTACAGTGTCACCATTGTCACCACC AGAGGGCAGCAGCCAGCCAGACCTCTGCTTCTCTCAAGGTCTTGTCTCCTGGCTCTCTTTATCTTTCCAAATCTTGTCCCAGCTGCTTCT GGTCTCATTCAACCCCAGGAGCACAGGTGGGAGAGTAGAGAGGCACTGGAAGCTGTAGGTGGTGTCCTTTGCCACTGTCTTGGTGAAGTC CCCAAGAGGTTAAACCCAGTTCCCAAAGCCACACCAAAGTCTTGCCAAGATTTCAACCTGACTCTTCTGTGTGACTGCCGGACCCCTGAG AGCAACAGGGAGGCCATTCCCAGATCATCTGTGAGACCTGGCTGGGGGTCCCAGACCCCAGCTATGGTATAGTAAGCTTTGGTCAGCTCC TTCCTTTTTGAGGGCATGAGGAAGGCAAAGCTGCAGTCAAGCGTTCATGAAGCAGTCTATGCCCCATGTAAACAGCGTGGCTGGTTAGTT AACCTCTCTGAGCCCTTCTCATTGGCTGAATTCATGACTGATGAGTAGTGAGAGAATATGAGTGAAGGTGATTTGTAAACTATGATGTGT CAAACACATTTAAGGGACAATGATGATACTAGAGAAAAAACACTGGACTCAGGCTCAGATGTGGGTTTGAGATCTGTCTGCCATTTACAG TGGGTGACTTTTGGGAAAGTCAGTTAACTTCTCTGGGTCTCCAATACCATCTGAAACCTCTCTAGAGTTGTAGGCACTGGGCCTATTTGA GGGGTTGTTTTTGCTAAGACCCTGGGAATGCCTCCTGTAGCTCAGCAGAAGGACCAGGGCCAGGTGGGTATTCCTGGTGGAAGCAAAGTC AGCTGACTGGGCACCCTCAAATGAACTTTTGTGGTTGTCAGGAACGTGTGACGACGGCTGGAGGCCAACAGAGTCCCTACAGGTGGTGCT CACGGTAATGCACCGACAATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGTAAGTGGGTCCCTCCAGGGGTCTCCT AGGATGAGGCCTCAGCCCCCAGTTTCCCATCACCTTTCCATAGGGCCTTGGGAGAGGCCCTATCCAGCCCGTTTTAGGTTTACCCTCACC TCTACTGGGGCTTCATTAATTCCTAGAAGCTTCCATCCCAGGTGTGGGGTCCTGATGCTTTATATCTGCAATTTGAAGGATCCTGGGCCA CTGAAATGCCCACTGGATGTTGATGAGACCAGAGGGTGACTCTAGGGATGAGGTGGAAGGGACAGCTTGGTTAGGGAGGCAGATAGCCAA TCGAAATCCCAGCTCCGAAATGAGGAGCTTGGGTTTCTGTTTCACAAGGTGTGCCAGGCCATAAGCACACCAGGAATATGAGAGAGGGGC TTAGGAAGAAACCAGAAAGAGAAACAATCCCATCTCAATTAACTGGGGTGGGAGCTGGGCGGGAGAAAAGCAGTGTGTGGGTATCTGGAA GCTGCATGTCACCTGCTCACTGCCCCTCTGCGCCTCTCACACACTGGCAGGCAAAGGTGATGGAAACTTGCTGCCAAGGGCTCTTGCTGC CTCCATTGCTTGCCTTTCCTTGTGCCCAGACATGTCCCCTCTTGTCCTCTGTCCTCTCCCATGCTGCCTACCACCCTCCCCTCCAACAAG AATCTGGCCCAAGGTCTCCGCTTCCTGGAACTCCCTTATCCCTACCCCTACTCTGTCTTCCTGTCCAGCAGTCTGTCTCCAAGATCCCCT AGAATGACCTCCTCTCAGCCCTCTCCTCCACACCCCCCAAGTCCCCACTACCTGGCCCCTCCCACTCCTCTGCCTTTTCAGCCACTGCTG CTCTCTTCTCTTCTCCCTTACCTGTCTCCCAGGTGTGTCATGGCCTGGTGCGGGAGGCTCTTACCTCCCCAAGCCCCACTGCTTCTCCTG CTGCCCGCTTGCTTCGGACTCTGGCAGAAACCCCACCTGCTGACACGTTCCTCCTGGGGAATTGGCAAGTGATTAGTGATGAGCTGTCAG CACAGGGCCCTAAAACTCCCCGAAGAAGCTGTGCCCCATCCCTAGACCCCTGTTCAGTGCCATTGGGCTAGAAGCAGCTCCCAGAGAGCC ATAGATTCCCCATGGCCCAAAAGGAGAATGAGGAAACTGGTCCAGTTGGGTGGATGGGTGGTTGGTTTCCCTTGACTCTACCTCAGGGAA TGAGGGAGGGGAGAGTTCCCACCACCCTTTCTTGATCCACACCAACAACAGGGGCCACTGGAAGTCTCCAAAACAGTCCAGTCCAGAAAC CTCCCCAAAGTGGTGATCCTTGGAAGCTGCTCTTCCCTTCTTTTGACCCTTGTTAAGCCCCATTGGCCCTCGATGAGAGTAGGGGAAACA GGTGCCGAGAAGCCCTCTGGGCATAAACCCCACTGCAGTTAACTAAGAGGTGCCACTGGAGTAGTCAGGGAAGGCTGGGGATAGAGGTGG TGGCATTGGGTACTCCTCCCAGCTTAACCAGACTTGGGTCCTCCTCAGGTGTTGGATGTGCCAGCGCCTCTGGCCGTGGCCCGCTAACCA >In-frame_EIF4A1_ENST00000380512_chr17_7478576_+_PHOSPHO1_ENST00000514112_chr17_47302366_-_2740nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGGACTGAGCCTAACCCCGAGGAGCGGCCGCGTGAGGCACCAGGAGCCCACCCGGCGCCGGGCGGGCGG GTCCATTTTGCCGCACAAGCCGGGCTATTGGCAAACTGCGGATGGGCAGGTCCACCTTCCTTCGGGGGTGAGCGGCCTGAGATCCAGAGA CAATGGCCCCGATGGGATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATGACATGAACCTCTCGGA GTCCCTTCTCCGTGGCATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTTGTATCAAGGGTTATGA TGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCAC CCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGAT GAGTATAATCCAAGGACCAGAGAAGTCTTCTCTGATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGT TAATTAAAAGCTATTTCTTACCCAAACGTAACCATTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGG CTGGCTGGGCAAGTTTGACTGTGTTCTGAATAAGCACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCA GAGCAGATGGACAGTCCTTTTCACCCTTGCTTAATAGCCAGAGCTGTTTCATGCCTGGGGCACACACAATTCTAATGCTGGACCAGGAAC GTGTGACGACGGCTGGAGGCCAACAGAGTCCCTACAGGTGGTGCTCACGGTAATGCACCGACAATGAGTGGCTGTTTTCCAGTTTCTGGC CTCCGCTGCCTATCTAGGGTAAGTGGGTCCCTCCAGGGGTCTCCTAGGATGAGGCCTCAGCCCCCAGTTTCCCATCACCTTTCCATAGGG CCTTGGGAGAGGCCCTATCCAGCCCGTTTTAGGTTTACCCTCACCTCTACTGGGGCTTCATTAATTCCTAGAAGCTTCCATCCCAGGTGT GGGGTCCTGATGCTTTATATCTGCAATTTGAAGGATCCTGGGCCACTGAAATGCCCACTGGATGTTGATGAGACCAGAGGGTGACTCTAG GGATGAGGTGGAAGGGACAGCTTGGTTAGGGAGGCAGATAGCCAATCGAAATCCCAGCTCCGAAATGAGGAGCTTGGGTTTCTGTTTCAC AAGGTGTGCCAGGCCATAAGCACACCAGGAATATGAGAGAGGGGCTTAGGAAGAAACCAGAAAGAGAAACAATCCCATCTCAATTAACTG GGGTGGGAGCTGGGCGGGAGAAAAGCAGTGTGTGGGTATCTGGAAGCTGCATGTCACCTGCTCACTGCCCCTCTGCGCCTCTCACACACT GGCAGGCAAAGGTGATGGAAACTTGCTGCCAAGGGCTCTTGCTGCCTCCATTGCTTGCCTTTCCTTGTGCCCAGACATGTCCCCTCTTGT CCTCTGTCCTCTCCCATGCTGCCTACCACCCTCCCCTCCAACAAGAATCTGGCCCAAGGTCTCCGCTTCCTGGAACTCCCTTATCCCTAC CCCTACTCTGTCTTCCTGTCCAGCAGTCTGTCTCCAAGATCCCCTAGAATGACCTCCTCTCAGCCCTCTCCTCCACACCCCCCAAGTCCC CACTACCTGGCCCCTCCCACTCCTCTGCCTTTTCAGCCACTGCTGCTCTCTTCTCTTCTCCCTTACCTGTCTCCCAGGTGTGTCATGGCC TGGTGCGGGAGGCTCTTACCTCCCCAAGCCCCACTGCTTCTCCTGCTGCCCGCTTGCTTCGGACTCTGGCAGAAACCCCACCTGCTGACA CGTTCCTCCTGGGGAATTGGCAAGTGATTAGTGATGAGCTGTCAGCACAGGGCCCTAAAACTCCCCGAAGAAGCTGTGCCCCATCCCTAG ACCCCTGTTCAGTGCCATTGGGCTAGAAGCAGCTCCCAGAGAGCCATAGATTCCCCATGGCCCAAAAGGAGAATGAGGAAACTGGTCCAG TTGGGTGGATGGGTGGTTGGTTTCCCTTGACTCTACCTCAGGGAATGAGGGAGGGGAGAGTTCCCACCACCCTTTCTTGATCCACACCAA CAACAGGGGCCACTGGAAGTCTCCAAAACAGTCCAGTCCAGAAACCTCCCCAAAGTGGTGATCCTTGGAAGCTGCTCTTCCCTTCTTTTG ACCCTTGTTAAGCCCCATTGGCCCTCGATGAGAGTAGGGGAAACAGGTGCCGAGAAGCCCTCTGGGCATAAACCCCACTGCAGTTAACTA AGAGGTGCCACTGGAGTAGTCAGGGAAGGCTGGGGATAGAGGTGGTGGCATTGGGTACTCCTCCCAGCTTAACCAGACTTGGGTCCTCCT CAGGTGTTGGATGTGCCAGCGCCTCTGGCCGTGGCCCGCTAACCAGCCTCTCCCGGGCGGGCTCCTGCCGCGCCCCCTCTCGCTTGCCCC |
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FusionGenePPI for EIF4A1_PHOSPHO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF4A1 | UPF2, EIF4G1, PDCD4, EIF3A, EIF4G3, EIF4E, EIF3B, EIF4G2, PAIP1, PABPC1, MEPCE, RPAP3, CHD1L, PRMT1, SRRM2, H2AFX, MYC, UCHL5, HDAC5, MAPK6, RAD21, CENPA, SIRT7, CUL3, CDK2, CUL1, COPS5, CAND1, AKT1, EIF4H, EIF4B, EIF4A2, RPSA, RPL8, RPL19, RPS26, EEF2, HSP90AB1, RPLP0P6, TMEM43, ABCC2, VDAC3, ZBTB43, ILF2, SDHA, ATP6V1A, HSPA5, EEF1A1, UQCRFS1, GPRC5A, NDUFB11, ATP5A1, ESR1, LIG4, FN1, VCAM1, ITGA4, CD81, NPM1, ADRB2, FBXO6, SH3RF2, TRAP1, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, UNK, MAEL, PNPT1, LAGE3, NFYB, NTRK1, IBTK, GAN, CRY1, CRY2, MCM2, CDC5L, U2AF2, WWP2, IBA57, EIF3H, EIF4A3, EIF3E, EIF3M, RPP25L, EIF3C, EIF4E3, EIF3D, KIF1B, EIF3I, TRIM25, G3BP1, FAM107A, HDAC6 | PHOSPHO1 | HLA-DMB, HLA-DRB1, ACY1, CHTF18 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4A1_PHOSPHO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PHOSPHO1 | Q8TCT1 | DB00122 | Choline | Phosphoethanolamine/phosphocholine phosphatase | small molecule | approved|nutraceutical |
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RelatedDiseases for EIF4A1_PHOSPHO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EIF4A1 | C0019693 | HIV Infections | 1 | CTD_human |
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