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Fusion gene ID: 11263 |
FusionGeneSummary for EIF3D_UCP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF3D_UCP2 | Fusion gene ID: 11263 | Hgene | Tgene | Gene symbol | EIF3D | UCP2 | Gene ID | 8664 | 7351 |
| Gene name | eukaryotic translation initiation factor 3 subunit D | uncoupling protein 2 | |
| Synonyms | EIF3S7|eIF3-p66|eIF3-zeta | BMIQ4|SLC25A8|UCPH | |
| Cytomap | 22q12.3 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit | mitochondrial uncoupling protein 2solute carrier family 25 member 8uncoupling protein 2 (mitochondrial, proton carrier) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15371 | P55851 | |
| Ensembl transtripts involved in fusion gene | ENST00000216190, ENST00000478547, ENST00000541106, ENST00000405442, | ENST00000310473, ENST00000536983, ENST00000542615, | |
| Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 6 X 6 X 1=36 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EIF3D [Title/Abstract] AND UCP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF3D | GO:0002191 | cap-dependent translational initiation | 27462815 |
| Hgene | EIF3D | GO:0006413 | translational initiation | 17581632 |
| Hgene | EIF3D | GO:0075522 | IRES-dependent viral translational initiation | 9573242 |
| Hgene | EIF3D | GO:0075525 | viral translational termination-reinitiation | 21347434 |
| Tgene | UCP2 | GO:0001666 | response to hypoxia | 22292025 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE260321 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000216190 | ENST00000310473 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000216190 | ENST00000536983 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000216190 | ENST00000542615 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000478547 | ENST00000310473 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000478547 | ENST00000536983 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000478547 | ENST00000542615 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000541106 | ENST00000310473 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000541106 | ENST00000536983 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000541106 | ENST00000542615 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000405442 | ENST00000310473 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000405442 | ENST00000536983 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
| intron-5UTR | ENST00000405442 | ENST00000542615 | EIF3D | chr22 | 36920681 | - | UCP2 | chr11 | 73693808 | - |
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FusionProtFeatures for EIF3D_UCP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF3D | UCP2 |
| mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}. | UCP are mitochondrial transporter proteins that createproton leaks across the inner mitochondrial membrane, thusuncoupling oxidative phosphorylation from ATP synthesis. As aresult, energy is dissipated in the form of heat. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF3D_UCP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF3D_UCP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF3D_UCP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF3D_UCP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | UCP2 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| Tgene | UCP2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | CTD_human |
| Tgene | UCP2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | UCP2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | UCP2 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | UCP2 | C0015695 | Fatty Liver | 1 | CTD_human |
| Tgene | UCP2 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Tgene | UCP2 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | UCP2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | UCP2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | UCP2 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | UCP2 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Tgene | UCP2 | C0678306 | alcohol sensitivity | 1 | PSYGENET |
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